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HSPA6 Promotes Ferroptosis in Triple-Negative Breast Cancer by Rewiring Lipid Metabolism to Potentiate Membrane Lipid Peroxidation.

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Title: HSPA6 Promotes Ferroptosis in Triple-Negative Breast Cancer by Rewiring Lipid Metabolism to Potentiate Membrane Lipid Peroxidation.
Authors: Hai LY; The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.; Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China., Yu ZH; The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.; Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China., Liu WB; The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.; Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China., Zhang YY; The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.; Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China., Xu Y; The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.; Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China., Cheng S; The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.; Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China., Yue HR; The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.; Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China., Guo ZY; The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.; Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China., Yan SJ; Shanghai Pudong Hospital, Fudan University, Shanghai, People's Republic of China, Shanghai 201200, China., Sun R; The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.; Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China., Liu XF; The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.; Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China., Liu BW; The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.; Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China., Wang X; The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.; Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China., Cao XC; The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.; Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China., Yu Y; The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.; Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China.
Source: International journal of biological sciences [Int J Biol Sci] 2026 Apr 08; Vol. 22 (8), pp. 4168-4193. Date of Electronic Publication: 2026 Apr 08 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Ivyspring International Country of Publication: Australia NLM ID: 101235568 Publication Model: eCollection Cited Medium: Internet ISSN: 1449-2288 (Electronic) Linking ISSN: 14492288 NLM ISO Abbreviation: Int J Biol Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Label: Title
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  Data: HSPA6 Promotes Ferroptosis in Triple-Negative Breast Cancer by Rewiring Lipid Metabolism to Potentiate Membrane Lipid Peroxidation.
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  Data: <searchLink fieldCode="AU" term="%22Hai+LY%22">Hai LY</searchLink>; The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.; Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China.<br /><searchLink fieldCode="AU" term="%22Yu+ZH%22">Yu ZH</searchLink>; The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.; Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China.<br /><searchLink fieldCode="AU" term="%22Liu+WB%22">Liu WB</searchLink>; The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.; Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China.<br /><searchLink fieldCode="AU" term="%22Zhang+YY%22">Zhang YY</searchLink>; The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.; Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China.<br /><searchLink fieldCode="AU" term="%22Xu+Y%22">Xu Y</searchLink>; The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.; Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China.<br /><searchLink fieldCode="AU" term="%22Cheng+S%22">Cheng S</searchLink>; The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.; Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China.<br /><searchLink fieldCode="AU" term="%22Yue+HR%22">Yue HR</searchLink>; The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.; Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China.<br /><searchLink fieldCode="AU" term="%22Guo+ZY%22">Guo ZY</searchLink>; The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.; Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China.<br /><searchLink fieldCode="AU" term="%22Yan+SJ%22">Yan SJ</searchLink>; Shanghai Pudong Hospital, Fudan University, Shanghai, People's Republic of China, Shanghai 201200, China.<br /><searchLink fieldCode="AU" term="%22Sun+R%22">Sun R</searchLink>; The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.; Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China.<br /><searchLink fieldCode="AU" term="%22Liu+XF%22">Liu XF</searchLink>; The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.; Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China.<br /><searchLink fieldCode="AU" term="%22Liu+BW%22">Liu BW</searchLink>; The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.; Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.; Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China.<br /><searchLink fieldCode="AU" term="%22Cao+XC%22">Cao XC</searchLink>; The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.; Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China.<br /><searchLink fieldCode="AU" term="%22Yu+Y%22">Yu Y</searchLink>; The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.; Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China.
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  Data: <searchLink fieldCode="JN" term="%22101235568%22">International journal of biological sciences</searchLink> [Int J Biol Sci] 2026 Apr 08; Vol. 22 (8), pp. 4168-4193. <i>Date of Electronic Publication: </i>2026 Apr 08 (<i>Print Publication: </i>2026).
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      – TitleFull: HSPA6 Promotes Ferroptosis in Triple-Negative Breast Cancer by Rewiring Lipid Metabolism to Potentiate Membrane Lipid Peroxidation.
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