Criterion and convergent validity of plasma biomarkers in early-onset Alzheimer's disease: Initial findings from LEADS.

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Title: Criterion and convergent validity of plasma biomarkers in early-onset Alzheimer's disease: Initial findings from LEADS.
Authors: Hammers DB; Department of Neurology Indiana University School of Medicine Indianapolis Indiana USA., Polsinelli A; Department of Psychology Simon Frasier University Vancouver British Columbia Canada., Eloyan A; Department of Biostatistics, Center for Statistical Sciences Brown University Providence Rhode Island USA., Taurone A; Department of Biostatistics, Center for Statistical Sciences Brown University Providence Rhode Island USA., Thangarajah M; Department of Biostatistics, Center for Statistical Sciences Brown University Providence Rhode Island USA., Foroud T; Department of Medical and Molecular Genetics Indiana University School of Medicine Indianapolis Indiana USA., Gao S; Department of Biostatistics Indiana University School of Medicine Indianapolis Indiana USA., Beckett L; Department of Public Health Sciences University of California - Davis Davis California USA., La Joie R; Department of Neurology University of California - San Francisco San Francisco California USA., Touroutoglou A; Department of Neurology Massachusetts General Hospital and Harvard Medical School Boston Massachusetts USA., Vemuri P; Department of Neurology Mayo Clinic Rochester Minnesota USA., Zetterberg H; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology The Sahlgrenska Academy, University of Gothenburg Mölndal Sweden.; Clinical Neurochemistry Laboratory Sahlgrenska University Hospital Mölndal Sweden.; Department of Pathology and Laboratory Medicine University of Wisconsin School of Medicine and Public Health Madison Wisconsin USA.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health University of Wisconsin-Madison Madison Wisconsin USA.; Department of Neurodegenerative Disease UCL Institute of Neurology London UK.; UK Dementia Research Institute at UCL London UK., Blennow K; Eli Lilly and Company Indianapolis Indiana USA., Nemes S; Department of Neurology Indiana University School of Medicine Indianapolis Indiana USA., Kostadinova R; Department of Neurology Indiana University School of Medicine Indianapolis Indiana USA., Aisen P; Alzheimer's Therapeutic Research Institute University of Southern California San Diego California USA., Nudelman KN; Department of Medical and Molecular Genetics Indiana University School of Medicine Indianapolis Indiana USA., Kirby K; Department of Neurology Indiana University School of Medicine Indianapolis Indiana USA., Atri A; Banner Sun Health Research Institute Sun City Arizona USA., Clark D; Department of Neurology Indiana University School of Medicine Indianapolis Indiana USA., Day GS; Department of Neurology Mayo Clinic Jacksonville Florida USA., Duara R; Wien Center for Alzheimer's Disease and Memory Disorders Mount Sinai Medical Center Miami Florida USA., Graff-Radford NR; Department of Neurology Mayo Clinic Jacksonville Florida USA., Grant I; Department of Psychiatry and Behavioral Sciences Mesulam Center for Cognitive Neurology and Alzheimer's Disease Feinberg School of Medicine Northwestern University Chicago Illinois USA., Honig LS; Taub Institute and Department of Neurology Columbia University Irving Medical Center New York New York USA., Johnson ECB; Department of Neurology and Human Genetics Emory University School of Medicine Atlanta Georgia USA., Jones DT; Department of Neurology Mayo Clinic Rochester Minnesota USA., Masdeu JC; Nantz National Alzheimer Center Houston Methodist and Weill Cornell Medicine Houston Texas USA., Mendez MF; Department of Neurology David Geffen School of Medicine at UCLA Los Angeles California USA., Parand L; Department of Neurology David Geffen School of Medicine at UCLA Los Angeles California USA., Womack K; Department of Neurology Washington University in St. Louis St. Louis Missouri USA., Musiek E; Department of Neurology Washington University in St. Louis St. Louis Missouri USA., Onyike CU; Department of Psychiatry and Behavioral Sciences Johns Hopkins University School of Medicine Baltimore Maryland USA., Riddle M; Department of Neurology Alpert Medical School, Brown University Providence Rhode Island USA., Rogalski E; Healthy Aging & Alzheimer's Research Care Center, Department of Neurology University of Chicago Chicago Illinois USA., Salloway S; Department of Neurology Alpert Medical School, Brown University Providence Rhode Island USA., Sha SJ; Department of Neurology & Neurological Sciences Stanford University Palo Alto California USA., Turner RS; Department of Neurology Georgetown University Washington D.C. USA., Wingo TS; Department of Neurology UC Davis Alzheimer's Disease Research Center University of California - Davis Davis California USA., Wolk DA; Department of Neurology Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA., Carrillo MC; Medical & Scientific Relations Division Alzheimer's Association Chicago Illinois USA., Rabinovici GD; Department of Neurology University of California - San Francisco San Francisco California USA., Dickerson BC; Department of Neurology Massachusetts General Hospital and Harvard Medical School Boston Massachusetts USA., Dage JL; Department of Neurology Indiana University School of Medicine Indianapolis Indiana USA., Apostolova LG; Department of Neurology Indiana University School of Medicine Indianapolis Indiana USA.; Department of Medical and Molecular Genetics Indiana University School of Medicine Indianapolis Indiana USA.; Department of Radiology and Imaging Sciences Center for Neuroimaging Indiana University School of Medicine Indianapolis Indianapolis Indiana USA.
Corporate Authors: LEADS Consortium
Source: Alzheimer's & dementia (Amsterdam, Netherlands) [Alzheimers Dement (Amst)] 2026 May 03; Vol. 18, pp. e70342. Date of Electronic Publication: 2026 May 03 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Wiley on behalf of the Alzheimer's Association Country of Publication: United States NLM ID: 101654604 Publication Model: eCollection Cited Medium: Print ISSN: 2352-8729 (Print) Linking ISSN: 23528729 NLM ISO Abbreviation: Alzheimers Dement (Amst) Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Criterion and convergent validity of plasma biomarkers in early-onset Alzheimer's disease: Initial findings from LEADS.
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Department of Biostatistics Indiana University School of Medicine Indianapolis Indiana USA.<br /><searchLink fieldCode="AU" term="%22Beckett+L%22">Beckett L</searchLink>; Department of Public Health Sciences University of California - Davis Davis California USA.<br /><searchLink fieldCode="AU" term="%22La+Joie+R%22">La Joie R</searchLink>; Department of Neurology University of California - San Francisco San Francisco California USA.<br /><searchLink fieldCode="AU" term="%22Touroutoglou+A%22">Touroutoglou A</searchLink>; Department of Neurology Massachusetts General Hospital and Harvard Medical School Boston Massachusetts USA.<br /><searchLink fieldCode="AU" term="%22Vemuri+P%22">Vemuri P</searchLink>; Department of Neurology Mayo Clinic Rochester Minnesota USA.<br /><searchLink fieldCode="AU" term="%22Zetterberg+H%22">Zetterberg H</searchLink>; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology The Sahlgrenska Academy, University of Gothenburg Mölndal Sweden.; Clinical Neurochemistry Laboratory Sahlgrenska University Hospital Mölndal Sweden.; Department of Pathology and Laboratory Medicine University of Wisconsin School of Medicine and Public Health Madison Wisconsin USA.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health University of Wisconsin-Madison Madison Wisconsin USA.; Department of Neurodegenerative Disease UCL Institute of Neurology London UK.; UK Dementia Research Institute at UCL London UK.<br /><searchLink fieldCode="AU" term="%22Blennow+K%22">Blennow K</searchLink>; Eli Lilly and Company Indianapolis Indiana USA.<br /><searchLink fieldCode="AU" term="%22Nemes+S%22">Nemes S</searchLink>; Department of Neurology Indiana University School of Medicine Indianapolis Indiana USA.<br /><searchLink fieldCode="AU" term="%22Kostadinova+R%22">Kostadinova R</searchLink>; Department of Neurology Indiana University School of Medicine Indianapolis Indiana USA.<br /><searchLink fieldCode="AU" term="%22Aisen+P%22">Aisen P</searchLink>; 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Department of Neurology Mayo Clinic Jacksonville Florida USA.<br /><searchLink fieldCode="AU" term="%22Grant+I%22">Grant I</searchLink>; Department of Psychiatry and Behavioral Sciences Mesulam Center for Cognitive Neurology and Alzheimer's Disease Feinberg School of Medicine Northwestern University Chicago Illinois USA.<br /><searchLink fieldCode="AU" term="%22Honig+LS%22">Honig LS</searchLink>; Taub Institute and Department of Neurology Columbia University Irving Medical Center New York New York USA.<br /><searchLink fieldCode="AU" term="%22Johnson+ECB%22">Johnson ECB</searchLink>; Department of Neurology and Human Genetics Emory University School of Medicine Atlanta Georgia USA.<br /><searchLink fieldCode="AU" term="%22Jones+DT%22">Jones DT</searchLink>; Department of Neurology Mayo Clinic Rochester Minnesota USA.<br /><searchLink fieldCode="AU" term="%22Masdeu+JC%22">Masdeu JC</searchLink>; Nantz National Alzheimer Center Houston Methodist and Weill Cornell Medicine Houston Texas USA.<br /><searchLink fieldCode="AU" term="%22Mendez+MF%22">Mendez MF</searchLink>; Department of Neurology David Geffen School of Medicine at UCLA Los Angeles California USA.<br /><searchLink fieldCode="AU" term="%22Parand+L%22">Parand L</searchLink>; Department of Neurology David Geffen School of Medicine at UCLA Los Angeles California USA.<br /><searchLink fieldCode="AU" term="%22Womack+K%22">Womack K</searchLink>; Department of Neurology Washington University in St. Louis St. Louis Missouri USA.<br /><searchLink fieldCode="AU" term="%22Musiek+E%22">Musiek E</searchLink>; Department of Neurology Washington University in St. Louis St. Louis Missouri USA.<br /><searchLink fieldCode="AU" term="%22Onyike+CU%22">Onyike CU</searchLink>; Department of Psychiatry and Behavioral Sciences Johns Hopkins University School of Medicine Baltimore Maryland USA.<br /><searchLink fieldCode="AU" term="%22Riddle+M%22">Riddle M</searchLink>; Department of Neurology Alpert Medical School, Brown University Providence Rhode Island USA.<br /><searchLink fieldCode="AU" term="%22Rogalski+E%22">Rogalski E</searchLink>; 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  Data: <searchLink fieldCode="JN" term="%22101654604%22">Alzheimer's & dementia (Amsterdam, Netherlands)</searchLink> [Alzheimers Dement (Amst)] 2026 May 03; Vol. 18, pp. e70342. <i>Date of Electronic Publication: </i>2026 May 03 (<i>Print Publication: </i>2026).
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