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The epitranscriptomic m6A RNA modification modulates the synapse in ageing and in a mouse model of synucleinopathy.

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Title: The epitranscriptomic m6A RNA modification modulates the synapse in ageing and in a mouse model of synucleinopathy.
Authors: Chopra A; Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, Göttingen, Germany., Xylaki M; Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, Göttingen, Germany.; Department of Neurology, University Medical Centre Göttingen, Göttingen, Germany., Yin F; Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, Göttingen, Germany., Castro-Hernández R; Department for Systems Medicine and Epigenetics, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany., Merghani M; Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, Göttingen, Germany., Grande V; Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, Göttingen, Germany., Mollenhauer B; Department of Neurology, University Medical Centre Göttingen, Göttingen, Germany.; Paracelsus Elena Klinik, Kassel, Germany., Fischer A; Department for Systems Medicine and Epigenetics, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.; Cluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC), University of Göttingen, Göttingen, Germany., Outeiro TF; Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, Göttingen, Germany. touteiro@gmail.com.; Faculdade de Medicina e Ciências Biomédicas, Algarve Biomedical Center Research Institute, Universidade do Algarve, Faro, Portugal. touteiro@gmail.com.; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK. touteiro@gmail.com.; Scientific employee with an honorary contract at Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Göttingen, Germany. touteiro@gmail.com.
Source: NPJ Parkinson's disease [NPJ Parkinsons Dis] 2026 May 06; Vol. 12 (1). Date of Electronic Publication: 2026 May 06.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101675390 Publication Model: Electronic Cited Medium: Print ISSN: 2373-8057 (Print) Linking ISSN: 23738057 NLM ISO Abbreviation: NPJ Parkinsons Dis Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: The epitranscriptomic m6A RNA modification modulates the synapse in ageing and in a mouse model of synucleinopathy.
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  Data: <searchLink fieldCode="AU" term="%22Chopra+A%22">Chopra A</searchLink>; Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Xylaki+M%22">Xylaki M</searchLink>; Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, Göttingen, Germany.; Department of Neurology, University Medical Centre Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Yin+F%22">Yin F</searchLink>; Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Castro-Hernández+R%22">Castro-Hernández R</searchLink>; Department for Systems Medicine and Epigenetics, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Merghani+M%22">Merghani M</searchLink>; Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Grande+V%22">Grande V</searchLink>; Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Mollenhauer+B%22">Mollenhauer B</searchLink>; Department of Neurology, University Medical Centre Göttingen, Göttingen, Germany.; Paracelsus Elena Klinik, Kassel, Germany.<br /><searchLink fieldCode="AU" term="%22Fischer+A%22">Fischer A</searchLink>; Department for Systems Medicine and Epigenetics, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.; Cluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC), University of Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Outeiro+TF%22">Outeiro TF</searchLink>; Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, Göttingen, Germany. touteiro@gmail.com.; Faculdade de Medicina e Ciências Biomédicas, Algarve Biomedical Center Research Institute, Universidade do Algarve, Faro, Portugal. touteiro@gmail.com.; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK. touteiro@gmail.com.; Scientific employee with an honorary contract at Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Göttingen, Germany. touteiro@gmail.com.
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  Data: <searchLink fieldCode="JN" term="%22101675390%22">NPJ Parkinson's disease</searchLink> [NPJ Parkinsons Dis] 2026 May 06; Vol. 12 (1). <i>Date of Electronic Publication: </i>2026 May 06.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101675390 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2373-8057 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223738057%22">23738057 </searchLink><i>NLM ISO Abbreviation: </i>NPJ Parkinsons Dis <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.1038/s41531-026-01362-3
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              Text: 2026 May 06
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