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Prefrontal to ventral tegmental area dynamics drive contingency degradation.

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Title: Prefrontal to ventral tegmental area dynamics drive contingency degradation.
Authors: Hjort MM; Graduate Program in Neuroscience, University of Washington, Seattle, WA, USA.; Center for Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, USA.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA., Garrett ZQ; Center for Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, USA.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA.; Department of Pharmacology, University of Washington, Seattle, WA, USA., Gordon AG; Center for Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, USA.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA., Ancell E; Center for Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, USA.; Department of Statistics, University of Washington, Seattle, WA, USA., Trzeciak M; Center for Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, USA.; Department of Pharmacology, University of Washington, Seattle, WA, USA., Lu PY; Center for Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, USA.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA., Bruchas MR; Center for Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, USA.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA.; Department of Pharmacology, University of Washington, Seattle, WA, USA., Witten DM; Center for Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, USA.; Department of Statistics, University of Washington, Seattle, WA, USA.; Department of Biostatistics, University of Washington, Seattle, WA, USA., Steinmetz NA; Center for Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, USA.; Department of Neurobiology and Biophysics, University of Washington, Seattle, WA, USA., Stuber GD; Center for Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, USA. gstuber@uw.edu.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA. gstuber@uw.edu.; Department of Pharmacology, University of Washington, Seattle, WA, USA. gstuber@uw.edu.
Source: Nature [Nature] 2026 May 06. Date of Electronic Publication: 2026 May 06.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Hjort+MM%22">Hjort MM</searchLink>; Graduate Program in Neuroscience, University of Washington, Seattle, WA, USA.; Center for Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, USA.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Garrett+ZQ%22">Garrett ZQ</searchLink>; Center for Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, USA.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA.; Department of Pharmacology, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Gordon+AG%22">Gordon AG</searchLink>; Center for Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, USA.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Ancell+E%22">Ancell E</searchLink>; Center for Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, USA.; Department of Statistics, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Trzeciak+M%22">Trzeciak M</searchLink>; Center for Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, USA.; Department of Pharmacology, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Lu+PY%22">Lu PY</searchLink>; Center for Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, USA.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Bruchas+MR%22">Bruchas MR</searchLink>; Center for Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, USA.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA.; Department of Pharmacology, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Witten+DM%22">Witten DM</searchLink>; Center for Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, USA.; Department of Statistics, University of Washington, Seattle, WA, USA.; Department of Biostatistics, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Steinmetz+NA%22">Steinmetz NA</searchLink>; Center for Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, USA.; Department of Neurobiology and Biophysics, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Stuber+GD%22">Stuber GD</searchLink>; Center for Neurobiology of Addiction Pain and Emotion, University of Washington, Seattle, WA, USA. gstuber@uw.edu.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA. gstuber@uw.edu.; Department of Pharmacology, University of Washington, Seattle, WA, USA. gstuber@uw.edu.
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              Text: 2026 May 06
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