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Abi3S212F Alzheimer's disease variant alters plaque structure and disrupts microglia.

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Title: Abi3S212F Alzheimer's disease variant alters plaque structure and disrupts microglia.
Authors: Butler CA; Department of Neurobiology and Behavior, University of California, Irvine, California, USA.; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA., Gee MS; Department of Neurobiology and Behavior, University of California, Irvine, California, USA.; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA., O'Gara K; Department of Neurobiology and Behavior, University of California, Irvine, California, USA., Milinkeviciute G; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA., Da Cunha C; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA., Kawauchi S; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.; Transgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, California, USA., Lu YH; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA., Kwang N; Department of Neurobiology and Behavior, University of California, Irvine, California, USA.; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA., Tsourmas KI; Department of Neurobiology and Behavior, University of California, Irvine, California, USA., Prekopa C; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA., Shi Z; Department of Neurobiology and Behavior, University of California, Irvine, California, USA., Liang HY; Department of Developmental and Cell Biology, University of California, Irvine, California, USA.; Center for Complex Biological Systems, University of California, Irvine, California, USA., Collins SD; Transgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, California, USA., Pashkutz ZA; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.; Transgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, California, USA., Sanchez JA; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.; Transgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, California, USA., Shi KX; Transgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, California, USA., Walker AD; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.; Transgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, California, USA., Wang S; Transgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, California, USA., Wong MLA; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.; Transgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, California, USA., Genaro K; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.; Transgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, California, USA., Neumann J; Transgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, California, USA., Gomez-Arboledas A; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA., Duong DM; ARCProteomics, Atlanta, Georgia, USA., Seyfried NT; Goizueta Alzheimer's Disease Research Center, Emory University School of Medicine, Atlanta, Georgia, USA., Tenner AJ; Department of Neurobiology and Behavior, University of California, Irvine, California, USA.; Department of Molecular Biology & Biochemistry, University of California, Irvine, California, USA.; Department of Pathology and Laboratory Medicine, University of California, Irvine, California, USA., LaFerla FM; Department of Neurobiology and Behavior, University of California, Irvine, California, USA.; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA., Mortazavi A; Department of Developmental and Cell Biology, University of California, Irvine, California, USA.; Center for Complex Biological Systems, University of California, Irvine, California, USA., Swarup V; Department of Neurobiology and Behavior, University of California, Irvine, California, USA.; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA., MacGregor GR; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.; Transgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, California, USA.; Department of Developmental and Cell Biology, University of California, Irvine, California, USA., Green KN; Department of Neurobiology and Behavior, University of California, Irvine, California, USA.; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2026 May; Vol. 22 (5), pp. e71452.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Abi3<superscript>S212F</superscript> Alzheimer's disease variant alters plaque structure and disrupts microglia.
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  Data: <searchLink fieldCode="AU" term="%22Butler+CA%22">Butler CA</searchLink>; Department of Neurobiology and Behavior, University of California, Irvine, California, USA.; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Gee+MS%22">Gee MS</searchLink>; Department of Neurobiology and Behavior, University of California, Irvine, California, USA.; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22O'Gara+K%22">O'Gara K</searchLink>; Department of Neurobiology and Behavior, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Milinkeviciute+G%22">Milinkeviciute G</searchLink>; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Da+Cunha+C%22">Da Cunha C</searchLink>; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Kawauchi+S%22">Kawauchi S</searchLink>; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.; Transgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Lu+YH%22">Lu YH</searchLink>; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Kwang+N%22">Kwang N</searchLink>; Department of Neurobiology and Behavior, University of California, Irvine, California, USA.; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Tsourmas+KI%22">Tsourmas KI</searchLink>; Department of Neurobiology and Behavior, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Prekopa+C%22">Prekopa C</searchLink>; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Shi+Z%22">Shi Z</searchLink>; Department of Neurobiology and Behavior, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Liang+HY%22">Liang HY</searchLink>; Department of Developmental and Cell Biology, University of California, Irvine, California, USA.; Center for Complex Biological Systems, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Collins+SD%22">Collins SD</searchLink>; Transgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Pashkutz+ZA%22">Pashkutz ZA</searchLink>; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.; Transgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Sanchez+JA%22">Sanchez JA</searchLink>; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.; Transgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Shi+KX%22">Shi KX</searchLink>; Transgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Walker+AD%22">Walker AD</searchLink>; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.; Transgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Transgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Wong+MLA%22">Wong MLA</searchLink>; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.; Transgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Genaro+K%22">Genaro K</searchLink>; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.; Transgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Neumann+J%22">Neumann J</searchLink>; Transgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Gomez-Arboledas+A%22">Gomez-Arboledas A</searchLink>; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Duong+DM%22">Duong DM</searchLink>; ARCProteomics, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Seyfried+NT%22">Seyfried NT</searchLink>; Goizueta Alzheimer's Disease Research Center, Emory University School of Medicine, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Tenner+AJ%22">Tenner AJ</searchLink>; Department of Neurobiology and Behavior, University of California, Irvine, California, USA.; Department of Molecular Biology & Biochemistry, University of California, Irvine, California, USA.; Department of Pathology and Laboratory Medicine, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22LaFerla+FM%22">LaFerla FM</searchLink>; Department of Neurobiology and Behavior, University of California, Irvine, California, USA.; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Mortazavi+A%22">Mortazavi A</searchLink>; Department of Developmental and Cell Biology, University of California, Irvine, California, USA.; Center for Complex Biological Systems, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Swarup+V%22">Swarup V</searchLink>; Department of Neurobiology and Behavior, University of California, Irvine, California, USA.; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22MacGregor+GR%22">MacGregor GR</searchLink>; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.; Transgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, California, USA.; Department of Developmental and Cell Biology, University of California, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Green+KN%22">Green KN</searchLink>; Department of Neurobiology and Behavior, University of California, Irvine, California, USA.; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.
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  Data: <searchLink fieldCode="JN" term="%22101231978%22">Alzheimer's & dementia : the journal of the Alzheimer's Association</searchLink> [Alzheimers Dement] 2026 May; Vol. 22 (5), pp. e71452.
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