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CRISPR and compound screens in a novel ex vivo tissue model identify DDR1 and ETA as regulators of cancer cell invasion.

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Title: CRISPR and compound screens in a novel ex vivo tissue model identify DDR1 and ETA as regulators of cancer cell invasion.
Authors: Liu J; Department of Urology, Ulm University Hospital, Ulm, Germany.; Department of Urology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA., Jiang W; Department of Urology, Ulm University Hospital, Ulm, Germany.; Department of Molecular Pharmacology and Therapeutics, Columbia University Irving Medical Center, New York, NY, USA., Wang X; Department of Urology, Ulm University Hospital, Ulm, Germany.; Department of Molecular Pharmacology and Therapeutics, Columbia University Irving Medical Center, New York, NY, USA.; Mol. Pharmacology and Exp. Therapeutics, Mayo Clinic College of Medicine and Science, Rochester, MN, USA., Azoitei A; Department of Urology, Ulm University Hospital, Ulm, Germany., Liu H; Department of Urology, Ulm University Hospital, Ulm, Germany., Najjar G; Department of Urology, Ulm University Hospital, Ulm, Germany., Liu K; Department of Urology, Ulm University Hospital, Ulm, Germany., Melzer MK; Department of Urology, Ulm University Hospital, Ulm, Germany., Stilgenbauer S; Department of Internal Medicine III, Ulm University Hospital, Ulm, Germany., Elati M; CANTHER, ONCOLille Institute, University of Lille, CNRS UMR 1277, Inserm U9020, Lille, France., Burkhalter MD; Department of Experimental and Clinical Pharmacology and Pharmacogenomics, Section of Pharmacogenomics, Eberhard-Karls-University Tübingen, Tübingen, Germany., Philipp M; Department of Experimental and Clinical Pharmacology and Pharmacogenomics, Section of Pharmacogenomics, Eberhard-Karls-University Tübingen, Tübingen, Germany., Wezel F; Department of Urology, Ulm University Hospital, Ulm, Germany., Zengerling F; Department of Urology, Ulm University Hospital, Ulm, Germany., Bolenz C; Department of Urology, Ulm University Hospital, Ulm, Germany. Christian.Bolenz@uniklinik-ulm.de., Günes C; Department of Urology, Ulm University Hospital, Ulm, Germany. Cagatay.Guenes@uni-ulm.de.
Source: Cellular & molecular biology letters [Cell Mol Biol Lett] 2026 May 06; Vol. 31 (1). Date of Electronic Publication: 2026 May 06.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 9607427 Publication Model: Electronic Cited Medium: Internet ISSN: 1689-1392 (Electronic) Linking ISSN: 14258153 NLM ISO Abbreviation: Cell Mol Biol Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: CRISPR and compound screens in a novel ex vivo tissue model identify DDR1 and ETA as regulators of cancer cell invasion.
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  Data: <searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Department of Urology, Ulm University Hospital, Ulm, Germany.; Department of Urology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Jiang+W%22">Jiang W</searchLink>; Department of Urology, Ulm University Hospital, Ulm, Germany.; Department of Molecular Pharmacology and Therapeutics, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of Urology, Ulm University Hospital, Ulm, Germany.; Department of Molecular Pharmacology and Therapeutics, Columbia University Irving Medical Center, New York, NY, USA.; Mol. Pharmacology and Exp. Therapeutics, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Azoitei+A%22">Azoitei A</searchLink>; Department of Urology, Ulm University Hospital, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Liu+H%22">Liu H</searchLink>; Department of Urology, Ulm University Hospital, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Najjar+G%22">Najjar G</searchLink>; Department of Urology, Ulm University Hospital, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Liu+K%22">Liu K</searchLink>; Department of Urology, Ulm University Hospital, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Melzer+MK%22">Melzer MK</searchLink>; Department of Urology, Ulm University Hospital, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Stilgenbauer+S%22">Stilgenbauer S</searchLink>; Department of Internal Medicine III, Ulm University Hospital, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Elati+M%22">Elati M</searchLink>; CANTHER, ONCOLille Institute, University of Lille, CNRS UMR 1277, Inserm U9020, Lille, France.<br /><searchLink fieldCode="AU" term="%22Burkhalter+MD%22">Burkhalter MD</searchLink>; Department of Experimental and Clinical Pharmacology and Pharmacogenomics, Section of Pharmacogenomics, Eberhard-Karls-University Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Philipp+M%22">Philipp M</searchLink>; Department of Experimental and Clinical Pharmacology and Pharmacogenomics, Section of Pharmacogenomics, Eberhard-Karls-University Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Wezel+F%22">Wezel F</searchLink>; Department of Urology, Ulm University Hospital, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Zengerling+F%22">Zengerling F</searchLink>; Department of Urology, Ulm University Hospital, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Bolenz+C%22">Bolenz C</searchLink>; Department of Urology, Ulm University Hospital, Ulm, Germany. Christian.Bolenz@uniklinik-ulm.de.<br /><searchLink fieldCode="AU" term="%22Günes+C%22">Günes C</searchLink>; Department of Urology, Ulm University Hospital, Ulm, Germany. Cagatay.Guenes@uni-ulm.de.
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  Data: <searchLink fieldCode="JN" term="%229607427%22">Cellular & molecular biology letters</searchLink> [Cell Mol Biol Lett] 2026 May 06; Vol. 31 (1). <i>Date of Electronic Publication: </i>2026 May 06.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9607427 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1689-1392 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214258153%22">14258153 </searchLink><i>NLM ISO Abbreviation: </i>Cell Mol Biol Lett <i>Subsets: </i>MEDLINE
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              Text: 2026 May 06
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