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Shuangshen granules enhance anti-PD1 therapy effectiveness in lung adenocarcinoma by modulating myeloid-derived suppressor cell-induced T cell exhaustion.

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Title: Shuangshen granules enhance anti-PD1 therapy effectiveness in lung adenocarcinoma by modulating myeloid-derived suppressor cell-induced T cell exhaustion.
Authors: He ZN; Department of Oncology, Academy of Chinese Medical Sciences, Guang'anmen Hospital, China , Beijing, 100053, China., Huang Q; Institute of Basic Research in Clinical Medicine, China, Academy of Chinese Medical Science , Beijing, 100700, China., Li Y; Department of Oncology, Academy of Chinese Medical Sciences, Guang'anmen Hospital, China , Beijing, 100053, China., Hu JQ; Department of Oncology, Academy of Chinese Medical Sciences, Guang'anmen Hospital, China , Beijing, 100053, China., Liu TT; Department of Oncology, Academy of Chinese Medical Sciences, Guang'anmen Hospital, China , Beijing, 100053, China., Zhao YW; Department of Oncology, Academy of Chinese Medical Sciences, Guang'anmen Hospital, China , Beijing, 100053, China., Ren XL; Department of Oncology, Academy of Chinese Medical Sciences, Guang'anmen Hospital, China , Beijing, 100053, China., He SL; Department of Oncology, Academy of Chinese Medical Sciences, Guang'anmen Hospital, China , Beijing, 100053, China.; Graduate School, Beijing University of Chinese Medicine, Beijing, 100000, China., Li Y; Department of Oncology, Academy of Chinese Medical Sciences, Guang'anmen Hospital, China , Beijing, 100053, China.; Graduate School, Beijing University of Chinese Medicine, Beijing, 100000, China., Shi BL; Department of Oncology, Academy of Chinese Medical Sciences, Guang'anmen Hospital, China , Beijing, 100053, China., Liu R; Department of Oncology, Academy of Chinese Medical Sciences, Guang'anmen Hospital, China , Beijing, 100053, China., Guo QJ; Department of Oncology, Academy of Chinese Medical Sciences, Guang'anmen Hospital, China , Beijing, 100053, China., Zhang X; Department of Oncology, Academy of Chinese Medical Sciences, Guang'anmen Hospital, China , Beijing, 100053, China., Shi Z; Institute of Basic Research in Clinical Medicine, China, Academy of Chinese Medical Science , Beijing, 100700, China. shizhan209@163.com., He J; Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, 361000, China. sayuri_he@163.com., Qi RZ; Department of Oncology, Academy of Chinese Medical Sciences, Guang'anmen Hospital, China , Beijing, 100053, China. qrz1211@126.com., Hua BJ; Department of Oncology, Academy of Chinese Medical Sciences, Guang'anmen Hospital, China , Beijing, 100053, China. huabaojinxs@126.com.
Source: Chinese medicine [Chin Med] 2026 May 06; Vol. 21 (1). Date of Electronic Publication: 2026 May 06.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101265109 Publication Model: Electronic Cited Medium: Print ISSN: 1749-8546 (Print) Linking ISSN: 17498546 NLM ISO Abbreviation: Chin Med Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Shuangshen granules enhance anti-PD1 therapy effectiveness in lung adenocarcinoma by modulating myeloid-derived suppressor cell-induced T cell exhaustion.
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  Data: <searchLink fieldCode="AU" term="%22He+ZN%22">He ZN</searchLink>; Department of Oncology, Academy of Chinese Medical Sciences, Guang'anmen Hospital, China , Beijing, 100053, China.<br /><searchLink fieldCode="AU" term="%22Huang+Q%22">Huang Q</searchLink>; Institute of Basic Research in Clinical Medicine, China, Academy of Chinese Medical Science , Beijing, 100700, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Department of Oncology, Academy of Chinese Medical Sciences, Guang'anmen Hospital, China , Beijing, 100053, China.<br /><searchLink fieldCode="AU" term="%22Hu+JQ%22">Hu JQ</searchLink>; Department of Oncology, Academy of Chinese Medical Sciences, Guang'anmen Hospital, China , Beijing, 100053, China.<br /><searchLink fieldCode="AU" term="%22Liu+TT%22">Liu TT</searchLink>; Department of Oncology, Academy of Chinese Medical Sciences, Guang'anmen Hospital, China , Beijing, 100053, China.<br /><searchLink fieldCode="AU" term="%22Zhao+YW%22">Zhao YW</searchLink>; Department of Oncology, Academy of Chinese Medical Sciences, Guang'anmen Hospital, China , Beijing, 100053, China.<br /><searchLink fieldCode="AU" term="%22Ren+XL%22">Ren XL</searchLink>; Department of Oncology, Academy of Chinese Medical Sciences, Guang'anmen Hospital, China , Beijing, 100053, China.<br /><searchLink fieldCode="AU" term="%22He+SL%22">He SL</searchLink>; Department of Oncology, Academy of Chinese Medical Sciences, Guang'anmen Hospital, China , Beijing, 100053, China.; Graduate School, Beijing University of Chinese Medicine, Beijing, 100000, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Department of Oncology, Academy of Chinese Medical Sciences, Guang'anmen Hospital, China , Beijing, 100053, China.; Graduate School, Beijing University of Chinese Medicine, Beijing, 100000, China.<br /><searchLink fieldCode="AU" term="%22Shi+BL%22">Shi BL</searchLink>; Department of Oncology, Academy of Chinese Medical Sciences, Guang'anmen Hospital, China , Beijing, 100053, China.<br /><searchLink fieldCode="AU" term="%22Liu+R%22">Liu R</searchLink>; Department of Oncology, Academy of Chinese Medical Sciences, Guang'anmen Hospital, China , Beijing, 100053, China.<br /><searchLink fieldCode="AU" term="%22Guo+QJ%22">Guo QJ</searchLink>; Department of Oncology, Academy of Chinese Medical Sciences, Guang'anmen Hospital, China , Beijing, 100053, China.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Department of Oncology, Academy of Chinese Medical Sciences, Guang'anmen Hospital, China , Beijing, 100053, China.<br /><searchLink fieldCode="AU" term="%22Shi+Z%22">Shi Z</searchLink>; Institute of Basic Research in Clinical Medicine, China, Academy of Chinese Medical Science , Beijing, 100700, China. shizhan209@163.com.<br /><searchLink fieldCode="AU" term="%22He+J%22">He J</searchLink>; Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, 361000, China. sayuri_he@163.com.<br /><searchLink fieldCode="AU" term="%22Qi+RZ%22">Qi RZ</searchLink>; Department of Oncology, Academy of Chinese Medical Sciences, Guang'anmen Hospital, China , Beijing, 100053, China. qrz1211@126.com.<br /><searchLink fieldCode="AU" term="%22Hua+BJ%22">Hua BJ</searchLink>; Department of Oncology, Academy of Chinese Medical Sciences, Guang'anmen Hospital, China , Beijing, 100053, China. huabaojinxs@126.com.
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  Data: <searchLink fieldCode="JN" term="%22101265109%22">Chinese medicine</searchLink> [Chin Med] 2026 May 06; Vol. 21 (1). <i>Date of Electronic Publication: </i>2026 May 06.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101265109 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>1749-8546 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217498546%22">17498546 </searchLink><i>NLM ISO Abbreviation: </i>Chin Med <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.1186/s13020-026-01391-3
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        Text: English
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      – TitleFull: Shuangshen granules enhance anti-PD1 therapy effectiveness in lung adenocarcinoma by modulating myeloid-derived suppressor cell-induced T cell exhaustion.
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              Text: 2026 May 06
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