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Mitochondrial Extracellular Vesicles Enhance Aortic Valve Calcification Via Carnitine O-Octanoyltransferase-Brief Report.

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Title: Mitochondrial Extracellular Vesicles Enhance Aortic Valve Calcification Via Carnitine O-Octanoyltransferase-Brief Report.
Authors: Itagawa R; Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences (R.I., T.O., T.T., Y.N., D.H., C.L.C., M.C.B., T.K., L.W., M.E.T., M.A., S.A.S., E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Okui T; Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences (R.I., T.O., T.T., Y.N., D.H., C.L.C., M.C.B., T.K., L.W., M.E.T., M.A., S.A.S., E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Tanaka T; Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences (R.I., T.O., T.T., Y.N., D.H., C.L.C., M.C.B., T.K., L.W., M.E.T., M.A., S.A.S., E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Nakamura Y; Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences (R.I., T.O., T.T., Y.N., D.H., C.L.C., M.C.B., T.K., L.W., M.E.T., M.A., S.A.S., E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Hosokawa D; Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences (R.I., T.O., T.T., Y.N., D.H., C.L.C., M.C.B., T.K., L.W., M.E.T., M.A., S.A.S., E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Clift CL; Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences (R.I., T.O., T.T., Y.N., D.H., C.L.C., M.C.B., T.K., L.W., M.E.T., M.A., S.A.S., E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Blaser MC; Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences (R.I., T.O., T.T., Y.N., D.H., C.L.C., M.C.B., T.K., L.W., M.E.T., M.A., S.A.S., E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Kasai T; Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences (R.I., T.O., T.T., Y.N., D.H., C.L.C., M.C.B., T.K., L.W., M.E.T., M.A., S.A.S., E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Weiss L; Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences (R.I., T.O., T.T., Y.N., D.H., C.L.C., M.C.B., T.K., L.W., M.E.T., M.A., S.A.S., E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Turner ME; Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences (R.I., T.O., T.T., Y.N., D.H., C.L.C., M.C.B., T.K., L.W., M.E.T., M.A., S.A.S., E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Billaud M; Department of Medicine, Center for Excellence in Vascular Biology (M.B., M.A., S.A.S., E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Aikawa M; Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences (R.I., T.O., T.T., Y.N., D.H., C.L.C., M.C.B., T.K., L.W., M.E.T., M.A., S.A.S., E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.; Department of Medicine, Center for Excellence in Vascular Biology (M.B., M.A., S.A.S., E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (M.A.)., Singh SA; Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences (R.I., T.O., T.T., Y.N., D.H., C.L.C., M.C.B., T.K., L.W., M.E.T., M.A., S.A.S., E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.; Department of Medicine, Center for Excellence in Vascular Biology (M.B., M.A., S.A.S., E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Aikawa E; Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences (R.I., T.O., T.T., Y.N., D.H., C.L.C., M.C.B., T.K., L.W., M.E.T., M.A., S.A.S., E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.; Department of Medicine, Center for Excellence in Vascular Biology (M.B., M.A., S.A.S., E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Source: Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2026 Jul; Vol. 46 (7), pp. e324456. Date of Electronic Publication: 2026 May 07.
Publication Type: Journal Article
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9505803 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4636 (Electronic) Linking ISSN: 10795642 NLM ISO Abbreviation: Arterioscler Thromb Vasc Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Mitochondrial Extracellular Vesicles Enhance Aortic Valve Calcification Via Carnitine O-Octanoyltransferase-Brief Report.
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  Data: <searchLink fieldCode="AU" term="%22Itagawa+R%22">Itagawa R</searchLink>; Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences (R.I., T.O., T.T., Y.N., D.H., C.L.C., M.C.B., T.K., L.W., M.E.T., M.A., S.A.S., E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Okui+T%22">Okui T</searchLink>; Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences (R.I., T.O., T.T., Y.N., D.H., C.L.C., M.C.B., T.K., L.W., M.E.T., M.A., S.A.S., E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Tanaka+T%22">Tanaka T</searchLink>; Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences (R.I., T.O., T.T., Y.N., D.H., C.L.C., M.C.B., T.K., L.W., M.E.T., M.A., S.A.S., E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Nakamura+Y%22">Nakamura Y</searchLink>; Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences (R.I., T.O., T.T., Y.N., D.H., C.L.C., M.C.B., T.K., L.W., M.E.T., M.A., S.A.S., E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Hosokawa+D%22">Hosokawa D</searchLink>; Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences (R.I., T.O., T.T., Y.N., D.H., C.L.C., M.C.B., T.K., L.W., M.E.T., M.A., S.A.S., E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Clift+CL%22">Clift CL</searchLink>; Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences (R.I., T.O., T.T., Y.N., D.H., C.L.C., M.C.B., T.K., L.W., M.E.T., M.A., S.A.S., E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Blaser+MC%22">Blaser MC</searchLink>; Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences (R.I., T.O., T.T., Y.N., D.H., C.L.C., M.C.B., T.K., L.W., M.E.T., M.A., S.A.S., E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Kasai+T%22">Kasai T</searchLink>; Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences (R.I., T.O., T.T., Y.N., D.H., C.L.C., M.C.B., T.K., L.W., M.E.T., M.A., S.A.S., E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Weiss+L%22">Weiss L</searchLink>; Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences (R.I., T.O., T.T., Y.N., D.H., C.L.C., M.C.B., T.K., L.W., M.E.T., M.A., S.A.S., E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Turner+ME%22">Turner ME</searchLink>; Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences (R.I., T.O., T.T., Y.N., D.H., C.L.C., M.C.B., T.K., L.W., M.E.T., M.A., S.A.S., E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Billaud+M%22">Billaud M</searchLink>; Department of Medicine, Center for Excellence in Vascular Biology (M.B., M.A., S.A.S., E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Aikawa+M%22">Aikawa M</searchLink>; Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences (R.I., T.O., T.T., Y.N., D.H., C.L.C., M.C.B., T.K., L.W., M.E.T., M.A., S.A.S., E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.; Department of Medicine, Center for Excellence in Vascular Biology (M.B., M.A., S.A.S., E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (M.A.).<br /><searchLink fieldCode="AU" term="%22Singh+SA%22">Singh SA</searchLink>; Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences (R.I., T.O., T.T., Y.N., D.H., C.L.C., M.C.B., T.K., L.W., M.E.T., M.A., S.A.S., E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.; Department of Medicine, Center for Excellence in Vascular Biology (M.B., M.A., S.A.S., E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Aikawa+E%22">Aikawa E</searchLink>; Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences (R.I., T.O., T.T., Y.N., D.H., C.L.C., M.C.B., T.K., L.W., M.E.T., M.A., S.A.S., E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.; Department of Medicine, Center for Excellence in Vascular Biology (M.B., M.A., S.A.S., E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
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        Value: 10.1161/ATVBAHA.126.324456
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        Text: English
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