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A transcriptomic-driven segmentation and cell simulation framework for high-resolution spatial transcriptomics and cell-cell communication.

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Title: A transcriptomic-driven segmentation and cell simulation framework for high-resolution spatial transcriptomics and cell-cell communication.
Authors: Wanchai V; Center for Musculoskeletal Disease Research, The University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Department of Biomedical Informatics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Bustamante-Gomez NC; Center for Musculoskeletal Disease Research, The University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Kurilung A; Center for Musculoskeletal Disease Research, The University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Department of Biomedical Informatics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Beenken KE; Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR 72205; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Cortes S; Department of Pharmacology & Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Smeltzer MS; Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR 72205; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Leung YK; Department of Pharmacology & Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Xiong J; Center for Musculoskeletal Disease Research, The University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Department of Orthopedic Surgery, The University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Almeida M; Center for Musculoskeletal Disease Research, The University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Division of Endocrinology, The University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Department of Orthopedic Surgery, The University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., O'Brien CA; Center for Musculoskeletal Disease Research, The University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Division of Endocrinology, The University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Department of Orthopedic Surgery, The University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, USA., Nookaew I; Center for Musculoskeletal Disease Research, The University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Department of Biomedical Informatics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Division of Endocrinology, The University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Department of Orthopedic Surgery, The University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Apr 28. Date of Electronic Publication: 2026 Apr 28.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: A transcriptomic-driven segmentation and cell simulation framework for high-resolution spatial transcriptomics and cell-cell communication.
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  Data: <searchLink fieldCode="AU" term="%22Wanchai+V%22">Wanchai V</searchLink>; Center for Musculoskeletal Disease Research, The University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Department of Biomedical Informatics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.<br /><searchLink fieldCode="AU" term="%22Bustamante-Gomez+NC%22">Bustamante-Gomez NC</searchLink>; Center for Musculoskeletal Disease Research, The University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.<br /><searchLink fieldCode="AU" term="%22Kurilung+A%22">Kurilung A</searchLink>; Center for Musculoskeletal Disease Research, The University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Department of Biomedical Informatics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.<br /><searchLink fieldCode="AU" term="%22Beenken+KE%22">Beenken KE</searchLink>; Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR 72205; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.<br /><searchLink fieldCode="AU" term="%22Cortes+S%22">Cortes S</searchLink>; Department of Pharmacology & Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.<br /><searchLink fieldCode="AU" term="%22Smeltzer+MS%22">Smeltzer MS</searchLink>; Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR 72205; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.<br /><searchLink fieldCode="AU" term="%22Leung+YK%22">Leung YK</searchLink>; Department of Pharmacology & Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.<br /><searchLink fieldCode="AU" term="%22Xiong+J%22">Xiong J</searchLink>; Center for Musculoskeletal Disease Research, The University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Department of Orthopedic Surgery, The University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.<br /><searchLink fieldCode="AU" term="%22Almeida+M%22">Almeida M</searchLink>; Center for Musculoskeletal Disease Research, The University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Division of Endocrinology, The University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Department of Orthopedic Surgery, The University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.<br /><searchLink fieldCode="AU" term="%22O'Brien+CA%22">O'Brien CA</searchLink>; Center for Musculoskeletal Disease Research, The University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Division of Endocrinology, The University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Department of Orthopedic Surgery, The University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, USA.<br /><searchLink fieldCode="AU" term="%22Nookaew+I%22">Nookaew I</searchLink>; Center for Musculoskeletal Disease Research, The University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Department of Biomedical Informatics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Division of Endocrinology, The University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Department of Orthopedic Surgery, The University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
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              Text: 2026 Apr 28
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