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LRRK2 regulates ArfGAP1 membrane localization, activity and neuronal integrity via phosphorylation within its lipid-sensing ALPS2 motif.

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Title: LRRK2 regulates ArfGAP1 membrane localization, activity and neuronal integrity via phosphorylation within its lipid-sensing ALPS2 motif.
Authors: Islam MS; Department of Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI, United States., Cóppola-Segovia V; Department of Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI, United States., Musso A; Laboratory of Molecular Neurodegenerative Research, Brain Mind Institute, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland., Moore DJ; Department of Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI, United States.
Source: Frontiers in molecular neuroscience [Front Mol Neurosci] 2026 Apr 21; Vol. 19, pp. 1786336. Date of Electronic Publication: 2026 Apr 21 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101477914 Publication Model: eCollection Cited Medium: Print ISSN: 1662-5099 (Print) Linking ISSN: 16625099 NLM ISO Abbreviation: Front Mol Neurosci Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: LRRK2 regulates ArfGAP1 membrane localization, activity and neuronal integrity via phosphorylation within its lipid-sensing ALPS2 motif.
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  Data: <searchLink fieldCode="AU" term="%22Islam+MS%22">Islam MS</searchLink>; Department of Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI, United States.<br /><searchLink fieldCode="AU" term="%22Cóppola-Segovia+V%22">Cóppola-Segovia V</searchLink>; Department of Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI, United States.<br /><searchLink fieldCode="AU" term="%22Musso+A%22">Musso A</searchLink>; Laboratory of Molecular Neurodegenerative Research, Brain Mind Institute, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Moore+DJ%22">Moore DJ</searchLink>; Department of Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI, United States.
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  Data: <searchLink fieldCode="JN" term="%22101477914%22">Frontiers in molecular neuroscience</searchLink> [Front Mol Neurosci] 2026 Apr 21; Vol. 19, pp. 1786336. <i>Date of Electronic Publication: </i>2026 Apr 21 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Research+Foundation%22">Frontiers Research Foundation </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101477914 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>1662-5099 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216625099%22">16625099 </searchLink><i>NLM ISO Abbreviation: </i>Front Mol Neurosci <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.3389/fnmol.2026.1786336
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      – Code: eng
        Text: English
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      – TitleFull: LRRK2 regulates ArfGAP1 membrane localization, activity and neuronal integrity via phosphorylation within its lipid-sensing ALPS2 motif.
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              Text: 2026 Apr 21
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