Comparison of outcomes of second-line durvalumab plus tremelimumab versus lenvatinib following first-line atezolizumab plus bevacizumab in unresectable hepatocellular carcinoma.
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| Title: | Comparison of outcomes of second-line durvalumab plus tremelimumab versus lenvatinib following first-line atezolizumab plus bevacizumab in unresectable hepatocellular carcinoma. |
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| Authors: | Nishioka C; Department of Gastroenterology and Hepatology, The University of Osaka, Graduate School of Medicine, Suita, Osaka, Japan., Tahata Y; Department of Gastroenterology and Hepatology, The University of Osaka, Graduate School of Medicine, Suita, Osaka, Japan., Maesaka K; Department of Gastroenterology and Hepatology, The University of Osaka, Graduate School of Medicine, Suita, Osaka, Japan., Kai M; Department of Gastroenterology and Hepatology, The University of Osaka, Graduate School of Medicine, Suita, Osaka, Japan., Shirai K; Department of Gastroenterology and Hepatology, The University of Osaka, Graduate School of Medicine, Suita, Osaka, Japan., Murai K; Department of Gastroenterology and Hepatology, The University of Osaka, Graduate School of Medicine, Suita, Osaka, Japan., Makino Y; Department of Gastroenterology and Hepatology, The University of Osaka, Graduate School of Medicine, Suita, Osaka, Japan., Saito Y; Department of Gastroenterology and Hepatology, The University of Osaka, Graduate School of Medicine, Suita, Osaka, Japan., Nozaki Y; Department of Gastroenterology and Hepatology, Kansai Rosai Hospital, Amagasaki, Hyogo, Japan., Nakabori T; Department of Hepatobiliary and Pancreatic Oncology, Osaka International Cancer Institute, Osaka, Osaka, Japan., Ishida H; Department of Gastroenterology and Hepatology, Ikeda Municipal Hospital, Ikeda, Osaka, Japan., Yakushijin T; Department of Gastroenterology and Hepatology, Osaka General Medical Center, Osaka, Osaka, Japan., Iio S; Department of Gastroenterology and Hepatology, Hyogo Prefectural Nishinomiya Hospital, Nishinomiya, Hyogo, Japan., Tatsumi N; Department of Gastroenterology and Hepatology, Japan Community Healthcare Organization Osaka Hospital, Osaka, Osaka, Japan., Imanaka K; Department of Gastroenterology and Hepatology, Itami City Hospital, Itami, Hyogo, Japan., Kakita N; Department of Gastroenterology and Hepatology, Kaizuka City Hospital, Kaizuka, Osaka, Japan., Sakamori R; Department of Gastroenterology and Hepatology, National Hospital Organization Osaka National Hospital, Osaka, Osaka, Japan., Hosui A; Department of Gastroenterology and Hepatology, Osaka Rosai Hospital, Sakai, Osaka, Japan., Miyazaki M; Department of Gastroenterology and Hepatology, Osaka Keisatsu Hospital, Osaka, Osaka, Japan., Matsumoto K; Department of Gastroenterology and Hepatology, Toyonaka Municipal Hospital, Toyonaka, Osaka, Japan., Nakahara M; Department of Gastroenterology and Hepatology, Minoh City Hospital, Minoh, Osaka, Japan., Doi Y; Department of Gastroenterology and Hepatology, Otemae Hospital, Osaka, Osaka, Japan., Sakakibara M; Department of Gastroenterology and Hepatology, Yao Municipal Hospital, Yao, Osaka, Japan., Hikita H; Department of Gastroenterology and Hepatology, The University of Osaka, Graduate School of Medicine, Suita, Osaka, Japan., Kodama T; Department of Gastroenterology and Hepatology, The University of Osaka, Graduate School of Medicine, Suita, Osaka, Japan., Takehara T; Department of Gastroenterology and Hepatology, Kansai Rosai Hospital, Amagasaki, Hyogo, Japan. |
| Source: | PloS one [PLoS One] 2026 May 07; Vol. 21 (5), pp. e0341395. Date of Electronic Publication: 2026 May 07 (Print Publication: 2026). |
| Publication Type: | Journal Article; Comparative Study |
| Journal Info: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42096473 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Comparison of outcomes of second-line durvalumab plus tremelimumab versus lenvatinib following first-line atezolizumab plus bevacizumab in unresectable hepatocellular carcinoma. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Nishioka+C%22">Nishioka C</searchLink>; Department of Gastroenterology and Hepatology, The University of Osaka, Graduate School of Medicine, Suita, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Tahata+Y%22">Tahata Y</searchLink>; Department of Gastroenterology and Hepatology, The University of Osaka, Graduate School of Medicine, Suita, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Maesaka+K%22">Maesaka K</searchLink>; Department of Gastroenterology and Hepatology, The University of Osaka, Graduate School of Medicine, Suita, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Kai+M%22">Kai M</searchLink>; Department of Gastroenterology and Hepatology, The University of Osaka, Graduate School of Medicine, Suita, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Shirai+K%22">Shirai K</searchLink>; Department of Gastroenterology and Hepatology, The University of Osaka, Graduate School of Medicine, Suita, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Murai+K%22">Murai K</searchLink>; Department of Gastroenterology and Hepatology, The University of Osaka, Graduate School of Medicine, Suita, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Makino+Y%22">Makino Y</searchLink>; Department of Gastroenterology and Hepatology, The University of Osaka, Graduate School of Medicine, Suita, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Saito+Y%22">Saito Y</searchLink>; Department of Gastroenterology and Hepatology, The University of Osaka, Graduate School of Medicine, Suita, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Nozaki+Y%22">Nozaki Y</searchLink>; Department of Gastroenterology and Hepatology, Kansai Rosai Hospital, Amagasaki, Hyogo, Japan.<br /><searchLink fieldCode="AU" term="%22Nakabori+T%22">Nakabori T</searchLink>; Department of Hepatobiliary and Pancreatic Oncology, Osaka International Cancer Institute, Osaka, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Ishida+H%22">Ishida H</searchLink>; Department of Gastroenterology and Hepatology, Ikeda Municipal Hospital, Ikeda, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Yakushijin+T%22">Yakushijin T</searchLink>; Department of Gastroenterology and Hepatology, Osaka General Medical Center, Osaka, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Iio+S%22">Iio S</searchLink>; Department of Gastroenterology and Hepatology, Hyogo Prefectural Nishinomiya Hospital, Nishinomiya, Hyogo, Japan.<br /><searchLink fieldCode="AU" term="%22Tatsumi+N%22">Tatsumi N</searchLink>; Department of Gastroenterology and Hepatology, Japan Community Healthcare Organization Osaka Hospital, Osaka, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Imanaka+K%22">Imanaka K</searchLink>; Department of Gastroenterology and Hepatology, Itami City Hospital, Itami, Hyogo, Japan.<br /><searchLink fieldCode="AU" term="%22Kakita+N%22">Kakita N</searchLink>; Department of Gastroenterology and Hepatology, Kaizuka City Hospital, Kaizuka, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Sakamori+R%22">Sakamori R</searchLink>; Department of Gastroenterology and Hepatology, National Hospital Organization Osaka National Hospital, Osaka, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Hosui+A%22">Hosui A</searchLink>; Department of Gastroenterology and Hepatology, Osaka Rosai Hospital, Sakai, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Miyazaki+M%22">Miyazaki M</searchLink>; Department of Gastroenterology and Hepatology, Osaka Keisatsu Hospital, Osaka, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Matsumoto+K%22">Matsumoto K</searchLink>; Department of Gastroenterology and Hepatology, Toyonaka Municipal Hospital, Toyonaka, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Nakahara+M%22">Nakahara M</searchLink>; Department of Gastroenterology and Hepatology, Minoh City Hospital, Minoh, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Doi+Y%22">Doi Y</searchLink>; Department of Gastroenterology and Hepatology, Otemae Hospital, Osaka, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Sakakibara+M%22">Sakakibara M</searchLink>; Department of Gastroenterology and Hepatology, Yao Municipal Hospital, Yao, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Hikita+H%22">Hikita H</searchLink>; Department of Gastroenterology and Hepatology, The University of Osaka, Graduate School of Medicine, Suita, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Kodama+T%22">Kodama T</searchLink>; Department of Gastroenterology and Hepatology, The University of Osaka, Graduate School of Medicine, Suita, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Takehara+T%22">Takehara T</searchLink>; Department of Gastroenterology and Hepatology, Kansai Rosai Hospital, Amagasaki, Hyogo, Japan. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101285081%22">PloS one</searchLink> [PLoS One] 2026 May 07; Vol. 21 (5), pp. e0341395. <i>Date of Electronic Publication: </i>2026 May 07 (<i>Print Publication: </i>2026). – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Comparative Study – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Public+Library+of+Science%22">Public Library of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101285081 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1932-6203 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219326203%22">19326203 </searchLink><i>NLM ISO Abbreviation: </i>PLoS One <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42096473 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1371/journal.pone.0341395 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: e0341395 Titles: – TitleFull: Comparison of outcomes of second-line durvalumab plus tremelimumab versus lenvatinib following first-line atezolizumab plus bevacizumab in unresectable hepatocellular carcinoma. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Nishioka C – PersonEntity: Name: NameFull: Tahata Y – PersonEntity: Name: NameFull: Maesaka K – PersonEntity: Name: NameFull: Kai M – PersonEntity: Name: NameFull: Shirai K – PersonEntity: Name: NameFull: Murai K – PersonEntity: Name: NameFull: Makino Y – PersonEntity: Name: NameFull: Saito Y – PersonEntity: Name: NameFull: Nozaki Y – PersonEntity: Name: NameFull: Nakabori T – PersonEntity: Name: NameFull: Ishida H – PersonEntity: Name: NameFull: Yakushijin T – PersonEntity: Name: NameFull: Iio S – PersonEntity: Name: NameFull: Tatsumi N – PersonEntity: Name: NameFull: Imanaka K – PersonEntity: Name: NameFull: Kakita N – PersonEntity: Name: NameFull: Sakamori R – PersonEntity: Name: NameFull: Hosui A – PersonEntity: Name: NameFull: Miyazaki M – PersonEntity: Name: NameFull: Matsumoto K – PersonEntity: Name: NameFull: Nakahara M – PersonEntity: Name: NameFull: Doi Y – PersonEntity: Name: NameFull: Sakakibara M – PersonEntity: Name: NameFull: Hikita H – PersonEntity: Name: NameFull: Kodama T – PersonEntity: Name: NameFull: Takehara T IsPartOfRelationships: – BibEntity: Dates: – D: 07 M: 05 Text: 2026 May 07 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1932-6203 Numbering: – Type: volume Value: 21 – Type: issue Value: 5 Titles: – TitleFull: PloS one Type: main |
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