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Aqueous extract of Solanum nigrum L. restrains colorectal cancer progression by blocking cancer-associated fibroblast-induced STAT3-Annexin A2 signaling.

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Title: Aqueous extract of Solanum nigrum L. restrains colorectal cancer progression by blocking cancer-associated fibroblast-induced STAT3-Annexin A2 signaling.
Authors: Zhang JQ; Department of Pharmacy, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, PR China., Zhao ZD; Department of Pharmacy, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, PR China., Qian XJ; Department of Pharmacy, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, PR China., Zheng QL; Department of Pharmacy, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, PR China., Cheng YS; Department of Pharmacy, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, PR China., Cui B; Experiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, 201203, PR China., Zhuang XY; Experiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, 201203, PR China., Guo JH; Norwegian Centre for Molecular Biosciences and Medicine, University of Oslo, Oslo, Norway., Hu C; Experiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, 201203, PR China. Electronic address: hucheng10200@shutcm.edu.cn., Zhang LC; Department of Pharmacy, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, PR China. Electronic address: zhanglichao@shutcm.edu.cn.
Source: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2026 Jul; Vol. 156, pp. 158257. Date of Electronic Publication: 2026 Apr 28.
Publication Type: Journal Article
Journal Info: Publisher: Urban & Fischer Verlag Country of Publication: Germany NLM ID: 9438794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-095X (Electronic) Linking ISSN: 09447113 NLM ISO Abbreviation: Phytomedicine Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Aqueous extract of Solanum nigrum L. restrains colorectal cancer progression by blocking cancer-associated fibroblast-induced STAT3-Annexin A2 signaling.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+JQ%22">Zhang JQ</searchLink>; Department of Pharmacy, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, PR China.<br /><searchLink fieldCode="AU" term="%22Zhao+ZD%22">Zhao ZD</searchLink>; Department of Pharmacy, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, PR China.<br /><searchLink fieldCode="AU" term="%22Qian+XJ%22">Qian XJ</searchLink>; Department of Pharmacy, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, PR China.<br /><searchLink fieldCode="AU" term="%22Zheng+QL%22">Zheng QL</searchLink>; Department of Pharmacy, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, PR China.<br /><searchLink fieldCode="AU" term="%22Cheng+YS%22">Cheng YS</searchLink>; Department of Pharmacy, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, PR China.<br /><searchLink fieldCode="AU" term="%22Cui+B%22">Cui B</searchLink>; Experiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, 201203, PR China.<br /><searchLink fieldCode="AU" term="%22Zhuang+XY%22">Zhuang XY</searchLink>; Experiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, 201203, PR China.<br /><searchLink fieldCode="AU" term="%22Guo+JH%22">Guo JH</searchLink>; Norwegian Centre for Molecular Biosciences and Medicine, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Hu+C%22">Hu C</searchLink>; Experiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, 201203, PR China. Electronic address: hucheng10200@shutcm.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhang+LC%22">Zhang LC</searchLink>; Department of Pharmacy, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, PR China. Electronic address: zhanglichao@shutcm.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%229438794%22">Phytomedicine : international journal of phytotherapy and phytopharmacology</searchLink> [Phytomedicine] 2026 Jul; Vol. 156, pp. 158257. <i>Date of Electronic Publication: </i>2026 Apr 28.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Urban+%26+Fischer+Verlag%22">Urban & Fischer Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>9438794 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1618-095X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209447113%22">09447113 </searchLink><i>NLM ISO Abbreviation: </i>Phytomedicine <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.phymed.2026.158257
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        Text: English
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        StartPage: 158257
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      – TitleFull: Aqueous extract of Solanum nigrum L. restrains colorectal cancer progression by blocking cancer-associated fibroblast-induced STAT3-Annexin A2 signaling.
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              Text: 2026 Jul
              Type: published
              Y: 2026
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