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Inherited IFNAR1 structural deficiency in severe adverse events following yellow fever vaccination.

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Title: Inherited IFNAR1 structural deficiency in severe adverse events following yellow fever vaccination.
Authors: Azamor T; Laboratory of high complexity (LACIFF). Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Fiocruz, Rio de Janeiro, Brazil; Laboratory of Immunological Technology (LATIM). Instituto de Tecnologia em Imunobiológicos-Bio-Manguinhos. Fiocruz, Rio de Janeiro, Brazil. Electronic address: tamiris.barros@fiocruz.br., Bastard P; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Paris, France; Paris Cité University, Imagine Institute, Paris, France; Pediatric Hematology-Immunology and Rheumatology Unit, Necker Hospital for Sick Children, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France., da Silva AMV; Laboratory of Immunological Technology (LATIM). Instituto de Tecnologia em Imunobiológicos-Bio-Manguinhos. Fiocruz, Rio de Janeiro, Brazil., Machado LA; Laboratory of high complexity (LACIFF). Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Fiocruz, Rio de Janeiro, Brazil., Gonçalves BDS; Laboratory of high complexity (LACIFF). Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Fiocruz, Rio de Janeiro, Brazil; Laboratory of Immunological Technology (LATIM). Instituto de Tecnologia em Imunobiológicos-Bio-Manguinhos. Fiocruz, Rio de Janeiro, Brazil., Jouanguy E; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Paris, France; Paris Cité University, Imagine Institute, Paris, France., Zhang Q; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Paris, France; Paris Cité University, Imagine Institute, Paris, France., Melgaço JG; Laboratory of Immunological Technology (LATIM). Instituto de Tecnologia em Imunobiológicos-Bio-Manguinhos. Fiocruz, Rio de Janeiro, Brazil., Coelho FS; Laboratory of Immunological Technology (LATIM). Instituto de Tecnologia em Imunobiológicos-Bio-Manguinhos. Fiocruz, Rio de Janeiro, Brazil., da Rosa LC; Laboratory of Immunological Technology (LATIM). Instituto de Tecnologia em Imunobiológicos-Bio-Manguinhos. Fiocruz, Rio de Janeiro, Brazil., Tubarão LN; Laboratory of Immunological Technology (LATIM). Instituto de Tecnologia em Imunobiológicos-Bio-Manguinhos. Fiocruz, Rio de Janeiro, Brazil., Cunha DP; Laboratory of high complexity (LACIFF). Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Fiocruz, Rio de Janeiro, Brazil., Agonigi BNDS; Laboratory of high complexity (LACIFF). Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Fiocruz, Rio de Janeiro, Brazil., de Almeida CD; Department of Clinical Affairs. Instituto de Tecnologia em Imunobiológicos-Bio-Manguinhos. Fiocruz, Rio de Janeiro, Brazil., Pedro RS; Department of Clinical Affairs. Instituto de Tecnologia em Imunobiológicos-Bio-Manguinhos. Fiocruz, Rio de Janeiro, Brazil., Alves NDS; Laboratory of Immunomolecular Analysis (LANIM). Instituto de Tecnologia em Imunobiológicos-Bio-Manguinhos. Fiocruz, Rio de Janeiro, Brazil., Dias BM; Laboratory of Immunomolecular Analysis (LANIM). Instituto de Tecnologia em Imunobiológicos-Bio-Manguinhos. Fiocruz, Rio de Janeiro, Brazil., Schwarcz WD; Laboratory of Immunomolecular Analysis (LANIM). Instituto de Tecnologia em Imunobiológicos-Bio-Manguinhos. Fiocruz, Rio de Janeiro, Brazil., Goudouris ES; Instituto de Puericultura e Pediatria Martagão Gesteira. Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Fonseca DLM; Interunit Postgraduate Program on Bioinformatics, Institute of Mathematics and Statistics (IME), University of São Paulo (USP), São Paulo, Brazil., Cabral-Marques O; Laboratory of Psychoneuroimmunology, Selye Lab, University of São Paulo School of Medicine, São Paulo, Brazil; Department of Medicine, Division of Molecular Medicine, Laboratory of Medical Investigation 29, University of São Paulo School of Medicine, São Paulo, Brazil., Casanova JL; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Paris, France; Paris Cité University, Imagine Institute, Paris, France; Howard Hughes Medical Institute, New York, NY, USA; Department of Pediatrics, Necker Sick Children Hospital, Paris, France., de Oliveira PMN; Department of Clinical Affairs. Instituto de Tecnologia em Imunobiológicos-Bio-Manguinhos. Fiocruz, Rio de Janeiro, Brazil., Maia MLS; Department of Clinical Affairs. Instituto de Tecnologia em Imunobiológicos-Bio-Manguinhos. Fiocruz, Rio de Janeiro, Brazil., Vasconcelos Z; Laboratory of high complexity (LACIFF). Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Fiocruz, Rio de Janeiro, Brazil., Ano Bom APD; Laboratory of Immunological Technology (LATIM). Instituto de Tecnologia em Imunobiológicos-Bio-Manguinhos. Fiocruz, Rio de Janeiro, Brazil.
Source: Clinical immunology (Orlando, Fla.) [Clin Immunol] 2026 Jun; Vol. 285, pp. 110711. Date of Electronic Publication: 2026 May 05.
Publication Type: Journal Article; Case Reports
Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 100883537 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-7035 (Electronic) Linking ISSN: 15216616 NLM ISO Abbreviation: Clin Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Inherited IFNAR1 structural deficiency in severe adverse events following yellow fever vaccination.
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  Data: <searchLink fieldCode="AU" term="%22Azamor+T%22">Azamor T</searchLink>; Laboratory of high complexity (LACIFF). Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Fiocruz, Rio de Janeiro, Brazil; Laboratory of Immunological Technology (LATIM). Instituto de Tecnologia em Imunobiológicos-Bio-Manguinhos. Fiocruz, Rio de Janeiro, Brazil. Electronic address: tamiris.barros@fiocruz.br.<br /><searchLink fieldCode="AU" term="%22Bastard+P%22">Bastard P</searchLink>; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Paris, France; Paris Cité University, Imagine Institute, Paris, France; Pediatric Hematology-Immunology and Rheumatology Unit, Necker Hospital for Sick Children, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.<br /><searchLink fieldCode="AU" term="%22da+Silva+AMV%22">da Silva AMV</searchLink>; Laboratory of Immunological Technology (LATIM). Instituto de Tecnologia em Imunobiológicos-Bio-Manguinhos. Fiocruz, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Machado+LA%22">Machado LA</searchLink>; Laboratory of high complexity (LACIFF). Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Fiocruz, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Gonçalves+BDS%22">Gonçalves BDS</searchLink>; Laboratory of high complexity (LACIFF). Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Fiocruz, Rio de Janeiro, Brazil; Laboratory of Immunological Technology (LATIM). Instituto de Tecnologia em Imunobiológicos-Bio-Manguinhos. Fiocruz, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Jouanguy+E%22">Jouanguy E</searchLink>; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Paris, France; Paris Cité University, Imagine Institute, Paris, France.<br /><searchLink fieldCode="AU" term="%22Zhang+Q%22">Zhang Q</searchLink>; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Paris, France; Paris Cité University, Imagine Institute, Paris, France.<br /><searchLink fieldCode="AU" term="%22Melgaço+JG%22">Melgaço JG</searchLink>; Laboratory of Immunological Technology (LATIM). Instituto de Tecnologia em Imunobiológicos-Bio-Manguinhos. Fiocruz, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Coelho+FS%22">Coelho FS</searchLink>; Laboratory of Immunological Technology (LATIM). Instituto de Tecnologia em Imunobiológicos-Bio-Manguinhos. Fiocruz, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22da+Rosa+LC%22">da Rosa LC</searchLink>; Laboratory of Immunological Technology (LATIM). Instituto de Tecnologia em Imunobiológicos-Bio-Manguinhos. Fiocruz, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Tubarão+LN%22">Tubarão LN</searchLink>; Laboratory of Immunological Technology (LATIM). Instituto de Tecnologia em Imunobiológicos-Bio-Manguinhos. Fiocruz, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Cunha+DP%22">Cunha DP</searchLink>; Laboratory of high complexity (LACIFF). Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Fiocruz, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Agonigi+BNDS%22">Agonigi BNDS</searchLink>; Laboratory of high complexity (LACIFF). Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Fiocruz, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Almeida+CD%22">de Almeida CD</searchLink>; Department of Clinical Affairs. Instituto de Tecnologia em Imunobiológicos-Bio-Manguinhos. Fiocruz, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Pedro+RS%22">Pedro RS</searchLink>; Department of Clinical Affairs. Instituto de Tecnologia em Imunobiológicos-Bio-Manguinhos. Fiocruz, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Alves+NDS%22">Alves NDS</searchLink>; Laboratory of Immunomolecular Analysis (LANIM). Instituto de Tecnologia em Imunobiológicos-Bio-Manguinhos. Fiocruz, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Dias+BM%22">Dias BM</searchLink>; Laboratory of Immunomolecular Analysis (LANIM). Instituto de Tecnologia em Imunobiológicos-Bio-Manguinhos. Fiocruz, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Schwarcz+WD%22">Schwarcz WD</searchLink>; Laboratory of Immunomolecular Analysis (LANIM). Instituto de Tecnologia em Imunobiológicos-Bio-Manguinhos. Fiocruz, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Goudouris+ES%22">Goudouris ES</searchLink>; Instituto de Puericultura e Pediatria Martagão Gesteira. Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Fonseca+DLM%22">Fonseca DLM</searchLink>; Interunit Postgraduate Program on Bioinformatics, Institute of Mathematics and Statistics (IME), University of São Paulo (USP), São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Cabral-Marques+O%22">Cabral-Marques O</searchLink>; Laboratory of Psychoneuroimmunology, Selye Lab, University of São Paulo School of Medicine, São Paulo, Brazil; Department of Medicine, Division of Molecular Medicine, Laboratory of Medical Investigation 29, University of São Paulo School of Medicine, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Casanova+JL%22">Casanova JL</searchLink>; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Paris, France; Paris Cité University, Imagine Institute, Paris, France; Howard Hughes Medical Institute, New York, NY, USA; Department of Pediatrics, Necker Sick Children Hospital, Paris, France.<br /><searchLink fieldCode="AU" term="%22de+Oliveira+PMN%22">de Oliveira PMN</searchLink>; Department of Clinical Affairs. Instituto de Tecnologia em Imunobiológicos-Bio-Manguinhos. Fiocruz, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Maia+MLS%22">Maia MLS</searchLink>; Department of Clinical Affairs. Instituto de Tecnologia em Imunobiológicos-Bio-Manguinhos. Fiocruz, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Vasconcelos+Z%22">Vasconcelos Z</searchLink>; Laboratory of high complexity (LACIFF). Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Fiocruz, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Ano+Bom+APD%22">Ano Bom APD</searchLink>; Laboratory of Immunological Technology (LATIM). Instituto de Tecnologia em Imunobiológicos-Bio-Manguinhos. Fiocruz, Rio de Janeiro, Brazil.
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