Docirbrutinib is a pan-mutant BTK inhibitor and inhibits B-cell receptor signaling in chronic lymphocytic leukemia cells in preclinical and early clinical investigations.
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| Title: | Docirbrutinib is a pan-mutant BTK inhibitor and inhibits B-cell receptor signaling in chronic lymphocytic leukemia cells in preclinical and early clinical investigations. |
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| Authors: | Timofeeva N; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Herrera B; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Fujiwara H; Carna Biosciences, Inc., Kobe, Japan., Asami T; Carna Biosciences, Inc., Kobe, Japan., Endo H; Carna Biosciences, Inc., Kobe, Japan., Hatakeyama M; Carna Biosciences, Inc., Kobe, Japan., Nakajima F; Carna Biosciences, Inc., Kobe, Japan., Ohmoto H; Carna Biosciences, Inc., Kobe, Japan., Nishioka Y; Carna Biosciences, Inc., Kobe, Japan., Miyamoto K; CarnaBio USA Inc., South San Francisco, CA, USA., Arimura A; Carna Biosciences, Inc., Kobe, Japan.; CarnaBio USA Inc., South San Francisco, CA, USA., Tantawy SI; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Internal Medicine and Clinical Hematology Department, Suez Canal University, Ismailia, Egypt., Pinilla-Ibarz J; Moffitt Cancer Center, Tampa, FL, USA., Coombs CC; University of California, Irvine, CA, USA., Jain N; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Sawa M; Carna Biosciences, Inc., Kobe, Japan., Gandhi V; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. vgandhi@mdanderson.org.; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. vgandhi@mdanderson.org. |
| Source: | Blood cancer journal [Blood Cancer J] 2026 May 07. Date of Electronic Publication: 2026 May 07. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101568469 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2044-5385 (Electronic) Linking ISSN: 20445385 NLM ISO Abbreviation: Blood Cancer J Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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