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Case Report: Compromised response of memory-formed bystander T cells after CD19 CAR-T cell therapy following CD20 bispecific antibody therapy.

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Title: Case Report: Compromised response of memory-formed bystander T cells after CD19 CAR-T cell therapy following CD20 bispecific antibody therapy.
Authors: Masuda Y; Department of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Ehime, Japan., Kato J; Department of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Ehime, Japan., Konishi T; Division of Blood Transfusion and Cell Therapy, Ehime University Hospital, Toon, Ehime, Japan., Honda T; Department of Clinical Laboratory, Ehime University Hospital, Toon, Ehime, Japan., Maruta M; Department of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Ehime, Japan., Kawasaki N; Department of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Ehime, Japan., Matsumoto M; Department of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Ehime, Japan., Oka K; Department of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Ehime, Japan., Mori K; Department of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Ehime, Japan., Nabe S; Department of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Ehime, Japan., Miyazaki Y; Department of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Ehime, Japan., Matsubara E; Department of Internal Medicine, Matsuyama Red Cross Hospital, Matsuyama, Ehime, Japan., Urata S; Department of Internal Medicine, Matsuyama Red Cross Hospital, Matsuyama, Ehime, Japan., Kinnami S; Department of Clinical Laboratory, Ehime University Hospital, Toon, Ehime, Japan., Doi Y; Division of Blood Transfusion and Cell Therapy, Ehime University Hospital, Toon, Ehime, Japan.; Department of Clinical Laboratory, Ehime University Hospital, Toon, Ehime, Japan., Takasuka Y; Department of Clinical Laboratory, Ehime University Hospital, Toon, Ehime, Japan., Yamanouchi J; Division of Blood Transfusion and Cell Therapy, Ehime University Hospital, Toon, Ehime, Japan., Ochi T; Department of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.; Division of Immune Regulation, Proteo-Science Center, Ehime University, Toon, Ehime, Japan., Takenaka K; Department of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.
Source: Frontiers in immunology [Front Immunol] 2026 Apr 22; Vol. 17, pp. 1756756. Date of Electronic Publication: 2026 Apr 22 (Print Publication: 2026).
Publication Type: Case Reports; Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Case Report: Compromised response of memory-formed bystander T cells after CD19 CAR-T cell therapy following CD20 bispecific antibody therapy.
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  Data: <searchLink fieldCode="AU" term="%22Masuda+Y%22">Masuda Y</searchLink>; Department of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.<br /><searchLink fieldCode="AU" term="%22Kato+J%22">Kato J</searchLink>; Department of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.<br /><searchLink fieldCode="AU" term="%22Konishi+T%22">Konishi T</searchLink>; Division of Blood Transfusion and Cell Therapy, Ehime University Hospital, Toon, Ehime, Japan.<br /><searchLink fieldCode="AU" term="%22Honda+T%22">Honda T</searchLink>; Department of Clinical Laboratory, Ehime University Hospital, Toon, Ehime, Japan.<br /><searchLink fieldCode="AU" term="%22Maruta+M%22">Maruta M</searchLink>; Department of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.<br /><searchLink fieldCode="AU" term="%22Kawasaki+N%22">Kawasaki N</searchLink>; Department of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.<br /><searchLink fieldCode="AU" term="%22Matsumoto+M%22">Matsumoto M</searchLink>; Department of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.<br /><searchLink fieldCode="AU" term="%22Oka+K%22">Oka K</searchLink>; Department of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.<br /><searchLink fieldCode="AU" term="%22Mori+K%22">Mori K</searchLink>; Department of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.<br /><searchLink fieldCode="AU" term="%22Nabe+S%22">Nabe S</searchLink>; Department of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.<br /><searchLink fieldCode="AU" term="%22Miyazaki+Y%22">Miyazaki Y</searchLink>; Department of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.<br /><searchLink fieldCode="AU" term="%22Matsubara+E%22">Matsubara E</searchLink>; Department of Internal Medicine, Matsuyama Red Cross Hospital, Matsuyama, Ehime, Japan.<br /><searchLink fieldCode="AU" term="%22Urata+S%22">Urata S</searchLink>; Department of Internal Medicine, Matsuyama Red Cross Hospital, Matsuyama, Ehime, Japan.<br /><searchLink fieldCode="AU" term="%22Kinnami+S%22">Kinnami S</searchLink>; Department of Clinical Laboratory, Ehime University Hospital, Toon, Ehime, Japan.<br /><searchLink fieldCode="AU" term="%22Doi+Y%22">Doi Y</searchLink>; Division of Blood Transfusion and Cell Therapy, Ehime University Hospital, Toon, Ehime, Japan.; Department of Clinical Laboratory, Ehime University Hospital, Toon, Ehime, Japan.<br /><searchLink fieldCode="AU" term="%22Takasuka+Y%22">Takasuka Y</searchLink>; Department of Clinical Laboratory, Ehime University Hospital, Toon, Ehime, Japan.<br /><searchLink fieldCode="AU" term="%22Yamanouchi+J%22">Yamanouchi J</searchLink>; Division of Blood Transfusion and Cell Therapy, Ehime University Hospital, Toon, Ehime, Japan.<br /><searchLink fieldCode="AU" term="%22Ochi+T%22">Ochi T</searchLink>; Department of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.; Division of Immune Regulation, Proteo-Science Center, Ehime University, Toon, Ehime, Japan.<br /><searchLink fieldCode="AU" term="%22Takenaka+K%22">Takenaka K</searchLink>; Department of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.
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  Data: <searchLink fieldCode="JN" term="%22101560960%22">Frontiers in immunology</searchLink> [Front Immunol] 2026 Apr 22; Vol. 17, pp. 1756756. <i>Date of Electronic Publication: </i>2026 Apr 22 (<i>Print Publication: </i>2026).
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