Intravenous Tirofiban After Tenecteplase in Acute Ischemic Stroke: The INSTANT Randomized Clinical Trial.
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| Title: | Intravenous Tirofiban After Tenecteplase in Acute Ischemic Stroke: The INSTANT Randomized Clinical Trial. |
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| Authors: | Liu X; Department of Neurology, The Affiliated Ganzhou Hospital of Nanchang University (Ganzhou People's Hospital), Ganzhou, China.; Ganzhou Hospital-Nanfang Hospital, Southern Medical University (Ganzhou People's Hospital), Ganzhou, China., Zhang F; Department of Neurology, The Affiliated Ganzhou Hospital of Nanchang University (Ganzhou People's Hospital), Ganzhou, China.; Ganzhou Hospital-Nanfang Hospital, Southern Medical University (Ganzhou People's Hospital), Ganzhou, China., Zhang C; Department of Neurology, The Affiliated Ganzhou Hospital of Nanchang University (Ganzhou People's Hospital), Ganzhou, China.; Ganzhou Hospital-Nanfang Hospital, Southern Medical University (Ganzhou People's Hospital), Ganzhou, China., Li Z; Department of Neurology, Mingguang People's Hospital, Chuzhou, China., Yuan G; Department of Emergency, Xiangtan Central Hospital (The Affiliated Hospital of Hunan University), Xiangtan, China., Kong D; Department of Neurology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, China., Xie S; Department of Neurology, The Affiliated Ganzhou Hospital of Nanchang University (Ganzhou People's Hospital), Ganzhou, China.; Ganzhou Hospital-Nanfang Hospital, Southern Medical University (Ganzhou People's Hospital), Ganzhou, China., Zhou M; Department of Neurology, The Affiliated Ganzhou Hospital of Nanchang University (Ganzhou People's Hospital), Ganzhou, China.; Ganzhou Hospital-Nanfang Hospital, Southern Medical University (Ganzhou People's Hospital), Ganzhou, China., Ye J; Department of Neurology, The Affiliated Ganzhou Hospital of Nanchang University (Ganzhou People's Hospital), Ganzhou, China.; Ganzhou Hospital-Nanfang Hospital, Southern Medical University (Ganzhou People's Hospital), Ganzhou, China., Lai Z; Department of Neurology, The Affiliated Ganzhou Hospital of Nanchang University (Ganzhou People's Hospital), Ganzhou, China.; Ganzhou Hospital-Nanfang Hospital, Southern Medical University (Ganzhou People's Hospital), Ganzhou, China., Li D; Department of Neurology, Zhongmeng Hospital of Hexigten Banner, Chifeng, China., Xu H; Department of Neurology, Yiling People's Hospital of Yichang City, Yichang, China., Chen L; Department of Neurology, Mingguang People's Hospital, Chuzhou, China., Cheng F; Department of Emergency, Xiangtan Central Hospital (The Affiliated Hospital of Hunan University), Xiangtan, China., Shi Y; Department of Neurology, People's Hospital of Xinfeng County, Xinfeng, China., Chen B; Department of Neurology, People's Hospital of Quannan County, Quannan, China., Hu W; Department of Neurology, People's Hospital of Ganxian District, Ganzhou, China., Liu H; Department of Neurology, People's Hospital of Dayu County, Dayu, China., Yin Y; Department of Neurology, People's Hospital of Shangyou County, Shangyou, China., Deng X; Department of Neurology, People's Hospital of Yichun, Yichun, China., Xie Z; Department of Neurology, People's Hospital of Yudu County, Yudu, China., Li C; Department of Neurology, Songyuan Jilin Oilfield Hospital, Songyuan, China., Shi J; Department of Neurology, Huangmei People's Hospital, Huangmei, China., Mei D; Department of Neurology, People's Hospital of Xunwu County, Xunwu, China., Liu B; Department of Neurology, People's Hospital of Wan'an County, Wan'an, China., Wang B; Department of Neurology, Hunan Xupu Chengnan Hospital, Huaihua, China., Zhou R; Department of Neurology, People's Hospital of Ruijin City, Ruijin, China., Liu J; Department of Neurology, Yingtan People's Hospital, Yingtan, China., Shen L; Department of Neurology, People's Hospital of Shaodong, Shaodong, China., Hu H; Department of Neurology, People's Hospital of Ningdu County, Ningdu, China., Xiao G; Department of Neurology, People's Hospital of Shicheng County, Shicheng, China., Guan X; Department of Neurology, Second People's Hospital of Yudu County, Yudu, China., Yuan S; Department of Neurology, Second Hospital of Xingguo County, Xingguo, China., Lv X; Department of Neurology, People's Hospital of Chongyi County, Chongyi, China., Liang S; Department of Neurology, Traditional Chinese Medicine Hospital of Xingguo County, Xingguo, China., Zeng X; Department of Neurology, Hunan University of Medicine Affiliated Pingjiang Hospital (Pingjiang County First People's Hospital), Pingjiang, China., Chen Y; Department of Neurology, Ji'an Central People's Hospital, Ji'an, China., Cao W; Department of Neurology, Jiangxi Provincial People's Hospital, Nanchang, China., Zheng C; Department of Neurology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China., Liu Y; Department of Neurology, The Affiliated Ganzhou Hospital of Nanchang University (Ganzhou People's Hospital), Ganzhou, China.; Ganzhou Hospital-Nanfang Hospital, Southern Medical University (Ganzhou People's Hospital), Ganzhou, China., Li J; Department of Neurology, The Affiliated Ganzhou Hospital of Nanchang University (Ganzhou People's Hospital), Ganzhou, China.; Ganzhou Hospital-Nanfang Hospital, Southern Medical University (Ganzhou People's Hospital), Ganzhou, China., Guan B; Department of Neurology, The Affiliated Ganzhou Hospital of Nanchang University (Ganzhou People's Hospital), Ganzhou, China.; Ganzhou Hospital-Nanfang Hospital, Southern Medical University (Ganzhou People's Hospital), Ganzhou, China., Lai T; Department of Neurology, The Affiliated Ganzhou Hospital of Nanchang University (Ganzhou People's Hospital), Ganzhou, China.; Ganzhou Hospital-Nanfang Hospital, Southern Medical University (Ganzhou People's Hospital), Ganzhou, China., Sun W; Department of Neurology, The Affiliated Ganzhou Hospital of Nanchang University (Ganzhou People's Hospital), Ganzhou, China.; Ganzhou Hospital-Nanfang Hospital, Southern Medical University (Ganzhou People's Hospital), Ganzhou, China., Zeng H; Department of Neurology, The Affiliated Ganzhou Hospital of Nanchang University (Ganzhou People's Hospital), Ganzhou, China.; Ganzhou Hospital-Nanfang Hospital, Southern Medical University (Ganzhou People's Hospital), Ganzhou, China., Zhang J; Department of Neurology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, China., Li S; Department of Neurology, First People's Hospital of Yulin, Yulin, China., Sang H; Department of Neurology, Hangzhou First People's Hospital and School of Medicine of Westlake University, Hangzhou, China., Tang Y; Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China., Wang D; Global Health Trials Unit, Liverpool School of Tropical Medicine, Liverpool, United Kingdom., Lu M; Health Science Center, Ningbo University, Ningbo, China., Kaesmacher J; University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland., Yogendrakumar V; Division of Neurology, Ottawa Hospital and the Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada.; Department of Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, Australia., Pan S; Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China., Nogueira RG; UPMC Stroke Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Hong D; Department of Neurology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China., Goyal M; Departments of Radiology and Clinical Neurosciences, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada., Thomalla G; Klinik und Poliklinik für Neurologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany., Nguyen TN; Department of Neurology, Boston Medical Center, Boston., Saver JL; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles., Yang Q; Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, China., Qiu Z; Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China., Zeng G; Department of Neurology, The Affiliated Ganzhou Hospital of Nanchang University (Ganzhou People's Hospital), Ganzhou, China.; Ganzhou Hospital-Nanfang Hospital, Southern Medical University (Ganzhou People's Hospital), Ganzhou, China. |
| Corporate Authors: | INSTANT Trial Authors for the INSTANT Investigators |
| Source: | JAMA [JAMA] 2026 Jun 09; Vol. 335 (22), pp. 1949-1958. |
| Publication Type: | Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial |
| Journal Info: | Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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