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First-in-human study of the dual A2A/A2B adenosine receptor antagonist muvadenant (M1069) in patients with advanced solid tumors.

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Title: First-in-human study of the dual A2A/A2B adenosine receptor antagonist muvadenant (M1069) in patients with advanced solid tumors.
Authors: Siu LL; Princess Margaret Cancer Centre, University Health Network, Toronto, Canada. Electronic address: lillian.siu@uhn.ca., Gutierrez ME; Hackensack University Medical Center, Hackensack, USA., Pudelko L; Merck Healthcare KGaA, Darmstadt, Germany., Ruth K; Merck Healthcare KGaA, Darmstadt, Germany., Filho MAFN; Merck Healthcare KGaA, Darmstadt, Germany., Zaynagetdinov R; EMD Serono Research & Development Institute Inc, Billerica, USA, an affiliate of Merck KGaA., Hu P; EMD Serono Research & Development Institute Inc, Billerica, USA, an affiliate of Merck KGaA., Kitzing T; Merck Healthcare KGaA, Darmstadt, Germany., Guenhan BK; Merck Healthcare KGaA, Darmstadt, Germany., Durutovic I; Merck Healthcare KGaA, Darmstadt, Germany., McKean M; Sarah Cannon Research Institute (SCRI), Nashville, USA.
Source: ESMO open [ESMO Open] 2026 May; Vol. 11 (5), pp. 106962. Date of Electronic Publication: 2026 May 07.
Publication Type: Journal Article; Clinical Trial, Phase I; Multicenter Study
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101690685 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2059-7029 (Electronic) Linking ISSN: 20597029 NLM ISO Abbreviation: ESMO Open Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: First-in-human study of the dual A<subscript>2</subscript><subscript>A</subscript>/A<subscript>2</subscript><subscript>B</subscript> adenosine receptor antagonist muvadenant (M1069) in patients with advanced solid tumors.
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  Data: <searchLink fieldCode="AU" term="%22Siu+LL%22">Siu LL</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Canada. Electronic address: lillian.siu@uhn.ca.<br /><searchLink fieldCode="AU" term="%22Gutierrez+ME%22">Gutierrez ME</searchLink>; Hackensack University Medical Center, Hackensack, USA.<br /><searchLink fieldCode="AU" term="%22Pudelko+L%22">Pudelko L</searchLink>; Merck Healthcare KGaA, Darmstadt, Germany.<br /><searchLink fieldCode="AU" term="%22Ruth+K%22">Ruth K</searchLink>; Merck Healthcare KGaA, Darmstadt, Germany.<br /><searchLink fieldCode="AU" term="%22Filho+MAFN%22">Filho MAFN</searchLink>; Merck Healthcare KGaA, Darmstadt, Germany.<br /><searchLink fieldCode="AU" term="%22Zaynagetdinov+R%22">Zaynagetdinov R</searchLink>; EMD Serono Research & Development Institute Inc, Billerica, USA, an affiliate of Merck KGaA.<br /><searchLink fieldCode="AU" term="%22Hu+P%22">Hu P</searchLink>; EMD Serono Research & Development Institute Inc, Billerica, USA, an affiliate of Merck KGaA.<br /><searchLink fieldCode="AU" term="%22Kitzing+T%22">Kitzing T</searchLink>; Merck Healthcare KGaA, Darmstadt, Germany.<br /><searchLink fieldCode="AU" term="%22Guenhan+BK%22">Guenhan BK</searchLink>; Merck Healthcare KGaA, Darmstadt, Germany.<br /><searchLink fieldCode="AU" term="%22Durutovic+I%22">Durutovic I</searchLink>; Merck Healthcare KGaA, Darmstadt, Germany.<br /><searchLink fieldCode="AU" term="%22McKean+M%22">McKean M</searchLink>; Sarah Cannon Research Institute (SCRI), Nashville, USA.
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  Data: <searchLink fieldCode="JN" term="%22101690685%22">ESMO open</searchLink> [ESMO Open] 2026 May; Vol. 11 (5), pp. 106962. <i>Date of Electronic Publication: </i>2026 May 07.
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  Data: Journal Article; Clinical Trial, Phase I; Multicenter Study
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101690685 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2059-7029 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220597029%22">20597029 </searchLink><i>NLM ISO Abbreviation: </i>ESMO Open <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.esmoop.2026.106962
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              Text: 2026 May
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