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Loss of mitochondrial DNA helicase in retinal macroglia drives neovascular retinopathy.

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Title: Loss of mitochondrial DNA helicase in retinal macroglia drives neovascular retinopathy.
Authors: Olander S; Stem Cells and Metabolism, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Karaman S; Wihuri Research Institute and Translational Cancer Medicine Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Suomi F; Stem Cells and Metabolism, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Aguilar K; Institute of Neurosciences, Universitat Autònoma de Barcelona, Bellaterra, Spain.; Department of Cellular Biology, Physiology and Immunology, Animal Physiology Unit, Faculty of Biosciences, Universitat Autònoma de Barcelona, Bellaterra, Spain., Zhaivoron A; Stem Cells and Metabolism, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Nedergaard M; Center for Translational Neuromedicine, University of Copenhagen, Copenhagen, Denmark.; Department of Neurosurgery, Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, USA., Smeds L; Molecular and Integrative Biosciences Research Programme, University of Helsinki, Helsinki, Finland., Tiihonen J; Molecular and Integrative Biosciences Research Programme, University of Helsinki, Helsinki, Finland.; Department of Neuroscience and Biomedical Engineering, Aalto University, Espoo, Finland., Quintana A; Institute of Neurosciences, Universitat Autònoma de Barcelona, Bellaterra, Spain.; Department of Cellular Biology, Physiology and Immunology, Animal Physiology Unit, Faculty of Biosciences, Universitat Autònoma de Barcelona, Bellaterra, Spain., Hidalgo J; Institute of Neurosciences, Universitat Autònoma de Barcelona, Bellaterra, Spain.; Department of Cellular Biology, Physiology and Immunology, Animal Physiology Unit, Faculty of Biosciences, Universitat Autònoma de Barcelona, Bellaterra, Spain., Alitalo K; Wihuri Research Institute and Translational Cancer Medicine Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Translational Cancer Medicine Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Ala-Laurila P; Molecular and Integrative Biosciences Research Programme, University of Helsinki, Helsinki, Finland.; Department of Neuroscience and Biomedical Engineering, Aalto University, Espoo, Finland., Ince-Dunn G; Stem Cells and Metabolism, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland. gulayse.ince@gmail.com., Suomalainen A; Stem Cells and Metabolism, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland. anu.wartiovaara@helsinki.fi.; HUS Diagnostic Center, Helsinki University Hospital, Helsinki, Finland. anu.wartiovaara@helsinki.fi.; HiLife, University of Helsinki, Helsinki, Finland. anu.wartiovaara@helsinki.fi.
Source: EMBO molecular medicine [EMBO Mol Med] 2026 May 08. Date of Electronic Publication: 2026 May 08.
Publication Type: Journal Article
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE
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  Data: Loss of mitochondrial DNA helicase in retinal macroglia drives neovascular retinopathy.
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  Data: <searchLink fieldCode="AU" term="%22Olander+S%22">Olander S</searchLink>; Stem Cells and Metabolism, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Karaman+S%22">Karaman S</searchLink>; Wihuri Research Institute and Translational Cancer Medicine Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Suomi+F%22">Suomi F</searchLink>; Stem Cells and Metabolism, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Aguilar+K%22">Aguilar K</searchLink>; Institute of Neurosciences, Universitat Autònoma de Barcelona, Bellaterra, Spain.; Department of Cellular Biology, Physiology and Immunology, Animal Physiology Unit, Faculty of Biosciences, Universitat Autònoma de Barcelona, Bellaterra, Spain.<br /><searchLink fieldCode="AU" term="%22Zhaivoron+A%22">Zhaivoron A</searchLink>; Stem Cells and Metabolism, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Nedergaard+M%22">Nedergaard M</searchLink>; Center for Translational Neuromedicine, University of Copenhagen, Copenhagen, Denmark.; Department of Neurosurgery, Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, USA.<br /><searchLink fieldCode="AU" term="%22Smeds+L%22">Smeds L</searchLink>; Molecular and Integrative Biosciences Research Programme, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Tiihonen+J%22">Tiihonen J</searchLink>; Molecular and Integrative Biosciences Research Programme, University of Helsinki, Helsinki, Finland.; Department of Neuroscience and Biomedical Engineering, Aalto University, Espoo, Finland.<br /><searchLink fieldCode="AU" term="%22Quintana+A%22">Quintana A</searchLink>; Institute of Neurosciences, Universitat Autònoma de Barcelona, Bellaterra, Spain.; Department of Cellular Biology, Physiology and Immunology, Animal Physiology Unit, Faculty of Biosciences, Universitat Autònoma de Barcelona, Bellaterra, Spain.<br /><searchLink fieldCode="AU" term="%22Hidalgo+J%22">Hidalgo J</searchLink>; Institute of Neurosciences, Universitat Autònoma de Barcelona, Bellaterra, Spain.; Department of Cellular Biology, Physiology and Immunology, Animal Physiology Unit, Faculty of Biosciences, Universitat Autònoma de Barcelona, Bellaterra, Spain.<br /><searchLink fieldCode="AU" term="%22Alitalo+K%22">Alitalo K</searchLink>; Wihuri Research Institute and Translational Cancer Medicine Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Translational Cancer Medicine Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Ala-Laurila+P%22">Ala-Laurila P</searchLink>; Molecular and Integrative Biosciences Research Programme, University of Helsinki, Helsinki, Finland.; Department of Neuroscience and Biomedical Engineering, Aalto University, Espoo, Finland.<br /><searchLink fieldCode="AU" term="%22Ince-Dunn+G%22">Ince-Dunn G</searchLink>; Stem Cells and Metabolism, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland. gulayse.ince@gmail.com.<br /><searchLink fieldCode="AU" term="%22Suomalainen+A%22">Suomalainen A</searchLink>; Stem Cells and Metabolism, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland. anu.wartiovaara@helsinki.fi.; HUS Diagnostic Center, Helsinki University Hospital, Helsinki, Finland. anu.wartiovaara@helsinki.fi.; HiLife, University of Helsinki, Helsinki, Finland. anu.wartiovaara@helsinki.fi.
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