Structure-guided design and synthesis of Etoricoxib analogues for selective COX-2 inhibition: in vitro assessment and computational insights with prospective in vivo confirmation.
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| Title: | Structure-guided design and synthesis of Etoricoxib analogues for selective COX-2 inhibition: in vitro assessment and computational insights with prospective in vivo confirmation. |
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| Authors: | Alqarni MH; Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, 11942, Al-Kharj, Saudi Arabia., Elgohary MK; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Egyptian Russian University, Badr City, 11829, Cairo, Egypt., Alkabbani MA; Pharmacology and Toxicology Department, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo, 11829, Egypt., Foudah AI; Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, 11942, Al-Kharj, Saudi Arabia., Alam A; Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, 11942, Al-Kharj, Saudi Arabia., Aljarba TM; Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, 11942, Al-Kharj, Saudi Arabia., Abdel-Aziz HA; Applied Organic Chemistry Department, National Research Centre, Dokki, Cairo, 12622, Egypt. ha.abdel-azizz@nrc.sci.eg., Elkotamy MS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alsalam University, Kafr Alzayat, Algharbia, 31611, Egypt. mahmoud.elkotamy@sue.edu.eg. |
| Source: | Molecular diversity [Mol Divers] 2026 May 09. Date of Electronic Publication: 2026 May 09. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: ESCOM Science Publishers Country of Publication: Netherlands NLM ID: 9516534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-501X (Electronic) Linking ISSN: 13811991 NLM ISO Abbreviation: Mol Divers Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42105141 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Structure-guided design and synthesis of Etoricoxib analogues for selective COX-2 inhibition: in vitro assessment and computational insights with prospective in vivo confirmation. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Alqarni+MH%22">Alqarni MH</searchLink>; Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, 11942, Al-Kharj, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Elgohary+MK%22">Elgohary MK</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Egyptian Russian University, Badr City, 11829, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Alkabbani+MA%22">Alkabbani MA</searchLink>; Pharmacology and Toxicology Department, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo, 11829, Egypt.<br /><searchLink fieldCode="AU" term="%22Foudah+AI%22">Foudah AI</searchLink>; Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, 11942, Al-Kharj, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Alam+A%22">Alam A</searchLink>; Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, 11942, Al-Kharj, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Aljarba+TM%22">Aljarba TM</searchLink>; Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, 11942, Al-Kharj, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Abdel-Aziz+HA%22">Abdel-Aziz HA</searchLink>; Applied Organic Chemistry Department, National Research Centre, Dokki, Cairo, 12622, Egypt. ha.abdel-azizz@nrc.sci.eg.<br /><searchLink fieldCode="AU" term="%22Elkotamy+MS%22">Elkotamy MS</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alsalam University, Kafr Alzayat, Algharbia, 31611, Egypt. mahmoud.elkotamy@sue.edu.eg. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229516534%22">Molecular diversity</searchLink> [Mol Divers] 2026 May 09. <i>Date of Electronic Publication: </i>2026 May 09. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22ESCOM+Science+Publishers%22">ESCOM Science Publishers </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>9516534 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1573-501X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213811991%22">13811991 </searchLink><i>NLM ISO Abbreviation: </i>Mol Divers <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42105141 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s11030-026-11555-w Languages: – Code: eng Text: English Titles: – TitleFull: Structure-guided design and synthesis of Etoricoxib analogues for selective COX-2 inhibition: in vitro assessment and computational insights with prospective in vivo confirmation. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Alqarni MH – PersonEntity: Name: NameFull: Elgohary MK – PersonEntity: Name: NameFull: Alkabbani MA – PersonEntity: Name: NameFull: Foudah AI – PersonEntity: Name: NameFull: Alam A – PersonEntity: Name: NameFull: Aljarba TM – PersonEntity: Name: NameFull: Abdel-Aziz HA – PersonEntity: Name: NameFull: Elkotamy MS IsPartOfRelationships: – BibEntity: Dates: – D: 09 M: 05 Text: 2026 May 09 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1573-501X Titles: – TitleFull: Molecular diversity Type: main |
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