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Molecularly diverse lonazolac-inspired pyrazole-cyanopyridin-2-one conjugates: design, synthesis, in vitro, in vivo and in silico studies as multi-target anti-inflammatory agents.

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Title: Molecularly diverse lonazolac-inspired pyrazole-cyanopyridin-2-one conjugates: design, synthesis, in vitro, in vivo and in silico studies as multi-target anti-inflammatory agents.
Authors: Aziz MA; Faculty of Pharmacy, Department of Medicinal Chemistry, Minia University, Minia, 61519, Egypt., Malebari AM; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, King Abdulaziz University, 21589, Jeddah, Saudi Arabia., Ibrahim TS; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, King Abdulaziz University, 21589, Jeddah, Saudi Arabia., Radwan MF; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, King Abdulaziz University, 21589, Jeddah, Saudi Arabia., Abouzed DEE; Faculty of Pharmacy, Department of Pharmacology & Toxicology, Sohag University, Sohag, 82524, Egypt., Allam RM; Pharmacology Department, Medical Research Institute, National Research Centre, Dokki, 12622, Cairo, Egypt., Alharbi M; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, King Abdulaziz University, 21589, Jeddah, Saudi Arabia., Khayyat AN; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, King Abdulaziz University, 21589, Jeddah, Saudi Arabia., Abuo-Rahma GEA; Faculty of Pharmacy, Department of Medicinal Chemistry, Minia University, Minia, 61519, Egypt. gamal.aborahma@mu.edu.eg.; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Deraya University, Minia, Egypt. gamal.aborahma@mu.edu.eg., Mohamed MFA; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Sohag University, Sohag, 82524, Egypt. mamdouh.fawzi@pharm.sohag.edu.eg.; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, New Valley University, New Valley, 72511, Egypt. mamdouh.fawzi@pharm.sohag.edu.eg.; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, New Valley National University, New Valley, 72511, Egypt. mamdouh.fawzi@pharm.sohag.edu.eg.
Source: Molecular diversity [Mol Divers] 2026 May 09. Date of Electronic Publication: 2026 May 09.
Publication Type: Journal Article
Journal Info: Publisher: ESCOM Science Publishers Country of Publication: Netherlands NLM ID: 9516534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-501X (Electronic) Linking ISSN: 13811991 NLM ISO Abbreviation: Mol Divers Subsets: MEDLINE
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  Data: Molecularly diverse lonazolac-inspired pyrazole-cyanopyridin-2-one conjugates: design, synthesis, in vitro, in vivo and in silico studies as multi-target anti-inflammatory agents.
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  Data: <searchLink fieldCode="AU" term="%22Aziz+MA%22">Aziz MA</searchLink>; Faculty of Pharmacy, Department of Medicinal Chemistry, Minia University, Minia, 61519, Egypt.<br /><searchLink fieldCode="AU" term="%22Malebari+AM%22">Malebari AM</searchLink>; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, King Abdulaziz University, 21589, Jeddah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Ibrahim+TS%22">Ibrahim TS</searchLink>; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, King Abdulaziz University, 21589, Jeddah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Radwan+MF%22">Radwan MF</searchLink>; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, King Abdulaziz University, 21589, Jeddah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Abouzed+DEE%22">Abouzed DEE</searchLink>; Faculty of Pharmacy, Department of Pharmacology & Toxicology, Sohag University, Sohag, 82524, Egypt.<br /><searchLink fieldCode="AU" term="%22Allam+RM%22">Allam RM</searchLink>; Pharmacology Department, Medical Research Institute, National Research Centre, Dokki, 12622, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Alharbi+M%22">Alharbi M</searchLink>; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, King Abdulaziz University, 21589, Jeddah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Khayyat+AN%22">Khayyat AN</searchLink>; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, King Abdulaziz University, 21589, Jeddah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Abuo-Rahma+GEA%22">Abuo-Rahma GEA</searchLink>; Faculty of Pharmacy, Department of Medicinal Chemistry, Minia University, Minia, 61519, Egypt. gamal.aborahma@mu.edu.eg.; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Deraya University, Minia, Egypt. gamal.aborahma@mu.edu.eg.<br /><searchLink fieldCode="AU" term="%22Mohamed+MFA%22">Mohamed MFA</searchLink>; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Sohag University, Sohag, 82524, Egypt. mamdouh.fawzi@pharm.sohag.edu.eg.; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, New Valley University, New Valley, 72511, Egypt. mamdouh.fawzi@pharm.sohag.edu.eg.; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, New Valley National University, New Valley, 72511, Egypt. mamdouh.fawzi@pharm.sohag.edu.eg.
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              Text: 2026 May 09
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