Molecularly diverse lonazolac-inspired pyrazole-cyanopyridin-2-one conjugates: design, synthesis, in vitro, in vivo and in silico studies as multi-target anti-inflammatory agents.
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| Title: | Molecularly diverse lonazolac-inspired pyrazole-cyanopyridin-2-one conjugates: design, synthesis, in vitro, in vivo and in silico studies as multi-target anti-inflammatory agents. |
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| Authors: | Aziz MA; Faculty of Pharmacy, Department of Medicinal Chemistry, Minia University, Minia, 61519, Egypt., Malebari AM; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, King Abdulaziz University, 21589, Jeddah, Saudi Arabia., Ibrahim TS; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, King Abdulaziz University, 21589, Jeddah, Saudi Arabia., Radwan MF; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, King Abdulaziz University, 21589, Jeddah, Saudi Arabia., Abouzed DEE; Faculty of Pharmacy, Department of Pharmacology & Toxicology, Sohag University, Sohag, 82524, Egypt., Allam RM; Pharmacology Department, Medical Research Institute, National Research Centre, Dokki, 12622, Cairo, Egypt., Alharbi M; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, King Abdulaziz University, 21589, Jeddah, Saudi Arabia., Khayyat AN; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, King Abdulaziz University, 21589, Jeddah, Saudi Arabia., Abuo-Rahma GEA; Faculty of Pharmacy, Department of Medicinal Chemistry, Minia University, Minia, 61519, Egypt. gamal.aborahma@mu.edu.eg.; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Deraya University, Minia, Egypt. gamal.aborahma@mu.edu.eg., Mohamed MFA; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Sohag University, Sohag, 82524, Egypt. mamdouh.fawzi@pharm.sohag.edu.eg.; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, New Valley University, New Valley, 72511, Egypt. mamdouh.fawzi@pharm.sohag.edu.eg.; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, New Valley National University, New Valley, 72511, Egypt. mamdouh.fawzi@pharm.sohag.edu.eg. |
| Source: | Molecular diversity [Mol Divers] 2026 May 09. Date of Electronic Publication: 2026 May 09. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: ESCOM Science Publishers Country of Publication: Netherlands NLM ID: 9516534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-501X (Electronic) Linking ISSN: 13811991 NLM ISO Abbreviation: Mol Divers Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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