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Efficacy and safety of enpatoran, a Toll-like receptor 7/8 inhibitor, in patients with skin manifestations of cutaneous lupus erythematosus or systemic lupus erythematosus: findings from Cohort A of a multicentre, international, double-blind, placebo-controlled, dose-finding phase 2 trial.

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Title: Efficacy and safety of enpatoran, a Toll-like receptor 7/8 inhibitor, in patients with skin manifestations of cutaneous lupus erythematosus or systemic lupus erythematosus: findings from Cohort A of a multicentre, international, double-blind, placebo-controlled, dose-finding phase 2 trial.
Authors: Morand EF; Centre for Inflammatory Diseases, Monash University, Melbourne, VIC, Australia. Electronic address: eric.morand@monash.edu., Werth VP; Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, and Corporal Michael J Crecenz VAMC, Philadelphia, PA, USA., Wenzel J; Department of Dermatology and Allergy, University Hospital of Bonn, Bonn, Germany., Furie R; Division of Rheumatology, Northwell, Great Neck, NY, USA., Dall'Era M; Division of Rheumatology, University of California San Francisco School of Medicine, San Francisco, CA, USA., Sanchez-Guerrero J; Division of Rheumatology, Mount Sinai Hospital/Toronto Western Hospital, University of Toronto, Toronto, ON, Canada., Roy S; Ares Trading SA, an affiliate of Merck KGaA, Eysins, Switzerland., Goodson SG; EMD Serono Research amp; Development Institute, Inc, an affiliate of Merck KGaA, Billerica, MA, USA., Moreau F; EMD Serono Research amp; Development Institute, Inc, an affiliate of Merck KGaA, Billerica, MA, USA., Gühring H; Merck Healthcare KGaA, Darmstadt, Germany., Sgouroudi E; Merck Healthcare KGaA, Darmstadt, Germany., Klopp-Schulze L; Merck Healthcare KGaA, Darmstadt, Germany., Pearson DR; Department of Dermatology, University of Minnesota, Minneapolis, MN, USA.
Source: The Lancet. Rheumatology [Lancet Rheumatol] 2026 Jul; Vol. 8 (7), pp. e513-e527. Date of Electronic Publication: 2026 May 07.
Publication Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Clinical Trial, Phase II
Journal Info: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101765308 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2665-9913 (Electronic) Linking ISSN: 26659913 NLM ISO Abbreviation: Lancet Rheumatol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Efficacy and safety of enpatoran, a Toll-like receptor 7/8 inhibitor, in patients with skin manifestations of cutaneous lupus erythematosus or systemic lupus erythematosus: findings from Cohort A of a multicentre, international, double-blind, placebo-controlled, dose-finding phase 2 trial.
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  Data: <searchLink fieldCode="AU" term="%22Morand+EF%22">Morand EF</searchLink>; Centre for Inflammatory Diseases, Monash University, Melbourne, VIC, Australia. Electronic address: eric.morand@monash.edu.<br /><searchLink fieldCode="AU" term="%22Werth+VP%22">Werth VP</searchLink>; Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, and Corporal Michael J Crecenz VAMC, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Wenzel+J%22">Wenzel J</searchLink>; Department of Dermatology and Allergy, University Hospital of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Furie+R%22">Furie R</searchLink>; Division of Rheumatology, Northwell, Great Neck, NY, USA.<br /><searchLink fieldCode="AU" term="%22Dall'Era+M%22">Dall'Era M</searchLink>; Division of Rheumatology, University of California San Francisco School of Medicine, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Sanchez-Guerrero+J%22">Sanchez-Guerrero J</searchLink>; Division of Rheumatology, Mount Sinai Hospital/Toronto Western Hospital, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Roy+S%22">Roy S</searchLink>; Ares Trading SA, an affiliate of Merck KGaA, Eysins, Switzerland.<br /><searchLink fieldCode="AU" term="%22Goodson+SG%22">Goodson SG</searchLink>; EMD Serono Research amp; Development Institute, Inc, an affiliate of Merck KGaA, Billerica, MA, USA.<br /><searchLink fieldCode="AU" term="%22Moreau+F%22">Moreau F</searchLink>; EMD Serono Research amp; Development Institute, Inc, an affiliate of Merck KGaA, Billerica, MA, USA.<br /><searchLink fieldCode="AU" term="%22Gühring+H%22">Gühring H</searchLink>; Merck Healthcare KGaA, Darmstadt, Germany.<br /><searchLink fieldCode="AU" term="%22Sgouroudi+E%22">Sgouroudi E</searchLink>; Merck Healthcare KGaA, Darmstadt, Germany.<br /><searchLink fieldCode="AU" term="%22Klopp-Schulze+L%22">Klopp-Schulze L</searchLink>; Merck Healthcare KGaA, Darmstadt, Germany.<br /><searchLink fieldCode="AU" term="%22Pearson+DR%22">Pearson DR</searchLink>; Department of Dermatology, University of Minnesota, Minneapolis, MN, USA.
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  Data: <searchLink fieldCode="JN" term="%22101765308%22">The Lancet. Rheumatology</searchLink> [Lancet Rheumatol] 2026 Jul; Vol. 8 (7), pp. e513-e527. <i>Date of Electronic Publication: </i>2026 May 07.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Ltd%22">Elsevier Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101765308 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2665-9913 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226659913%22">26659913 </searchLink><i>NLM ISO Abbreviation: </i>Lancet Rheumatol <i>Subsets: </i>MEDLINE
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