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Dual human lung models reveal compartment-specific activity of anti-tuberculosis drugs and host-directed therapies.

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Title: Dual human lung models reveal compartment-specific activity of anti-tuberculosis drugs and host-directed therapies.
Authors: Barbosa Bomfim CC; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France., Faivre N; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.; International Research Project CNRS 'MAC-TB/HIV', Toulouse, France., Benoist T; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France., Popis M; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France., Suire B; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France., Pericat D; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France., Sánchez-López JM; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.; Unidad de Investigación Médica en Genética Humana (UIMGH), Hospital de Pediatría Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Mexico City, México.; Children's Hospital of Tlaxcala, Tlaxcala, México., Aponte-Castillo BM; Unidad de Investigación Médica en Genética Humana (UIMGH), Hospital de Pediatría Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Mexico City, México., Näser E; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France., Viana P; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France., Guibert N; Service de Pneumologie, Hôpital Larrey, CHU de Toulouse, Toulouse, France., Vergé R; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.; Service de Chirurgie Thoracique, Hôpital Larrey, CHU de Toulouse, Toulouse, France., Mazières J; Service de Pneumologie, Hôpital Larrey, CHU de Toulouse, Toulouse, France., Métais A; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France., Poincloux R; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France., Raynaud-Messina B; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France., Dumas F; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France., Neyrolles O; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.; International Research Project CNRS 'MAC-TB/HIV', Toulouse, France., Vérollet C; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.; International Research Project CNRS 'MAC-TB/HIV', Toulouse, France., Meunier E; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France., Lugo-Villarino G; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.; International Research Project CNRS 'MAC-TB/HIV', Toulouse, France., Cougoule C; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.
Source: Microbiology spectrum [Microbiol Spectr] 2026 Jun 02; Vol. 14 (6), pp. e0372925. Date of Electronic Publication: 2026 May 11.
Publication Type: Journal Article
Journal Info: Publisher: ASM Press Country of Publication: United States NLM ID: 101634614 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2165-0497 (Electronic) Linking ISSN: 21650497 NLM ISO Abbreviation: Microbiol Spectr Subsets: MEDLINE
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  Data: Dual human lung models reveal compartment-specific activity of anti-tuberculosis drugs and host-directed therapies.
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  Data: <searchLink fieldCode="AU" term="%22Barbosa+Bomfim+CC%22">Barbosa Bomfim CC</searchLink>; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Faivre+N%22">Faivre N</searchLink>; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.; International Research Project CNRS 'MAC-TB/HIV', Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Benoist+T%22">Benoist T</searchLink>; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Popis+M%22">Popis M</searchLink>; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Suire+B%22">Suire B</searchLink>; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Pericat+D%22">Pericat D</searchLink>; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Sánchez-López+JM%22">Sánchez-López JM</searchLink>; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.; Unidad de Investigación Médica en Genética Humana (UIMGH), Hospital de Pediatría Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Mexico City, México.; Children's Hospital of Tlaxcala, Tlaxcala, México.<br /><searchLink fieldCode="AU" term="%22Aponte-Castillo+BM%22">Aponte-Castillo BM</searchLink>; Unidad de Investigación Médica en Genética Humana (UIMGH), Hospital de Pediatría Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Mexico City, México.<br /><searchLink fieldCode="AU" term="%22Näser+E%22">Näser E</searchLink>; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Viana+P%22">Viana P</searchLink>; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Guibert+N%22">Guibert N</searchLink>; Service de Pneumologie, Hôpital Larrey, CHU de Toulouse, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Vergé+R%22">Vergé R</searchLink>; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.; Service de Chirurgie Thoracique, Hôpital Larrey, CHU de Toulouse, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Mazières+J%22">Mazières J</searchLink>; Service de Pneumologie, Hôpital Larrey, CHU de Toulouse, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Métais+A%22">Métais A</searchLink>; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Poincloux+R%22">Poincloux R</searchLink>; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Raynaud-Messina+B%22">Raynaud-Messina B</searchLink>; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Dumas+F%22">Dumas F</searchLink>; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Neyrolles+O%22">Neyrolles O</searchLink>; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.; International Research Project CNRS 'MAC-TB/HIV', Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Vérollet+C%22">Vérollet C</searchLink>; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.; International Research Project CNRS 'MAC-TB/HIV', Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Meunier+E%22">Meunier E</searchLink>; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Lugo-Villarino+G%22">Lugo-Villarino G</searchLink>; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.; International Research Project CNRS 'MAC-TB/HIV', Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Cougoule+C%22">Cougoule C</searchLink>; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.
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  Data: <searchLink fieldCode="JN" term="%22101634614%22">Microbiology spectrum</searchLink> [Microbiol Spectr] 2026 Jun 02; Vol. 14 (6), pp. e0372925. <i>Date of Electronic Publication: </i>2026 May 11.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22ASM+Press%22">ASM Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101634614 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2165-0497 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2221650497%22">21650497 </searchLink><i>NLM ISO Abbreviation: </i>Microbiol Spectr <i>Subsets: </i>MEDLINE
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