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Proteomic comparison of human neural cell-derived extracellular vesicles and parental cells from Alzheimer's disease and cognitively normal individuals.

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Title: Proteomic comparison of human neural cell-derived extracellular vesicles and parental cells from Alzheimer's disease and cognitively normal individuals.
Authors: Xin JY; Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 400042, China., Liu J; Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 400042, China.; Department of Cognitive Impairment Research, Chongqing Institute for Brain and Intelligence, Guangyang Bay Laboratory, Chongqing, 401336, China., Dong HM; Department of Cognitive Impairment Research, Chongqing Institute for Brain and Intelligence, Guangyang Bay Laboratory, Chongqing, 401336, China., Yu HL; Carrier Biomed (Suzhou) Co., Ltd., Suzhou, 215000, China., Xiao ZS; Department of Cognitive Impairment Research, Chongqing Institute for Brain and Intelligence, Guangyang Bay Laboratory, Chongqing, 401336, China., Hu JN; Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 400042, China., Jiang Q; Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 400042, China., Zhu YP; Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 400042, China., Feng L; Department of Cognitive Impairment Research, Chongqing Institute for Brain and Intelligence, Guangyang Bay Laboratory, Chongqing, 401336, China., Feng Y; Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 400042, China., Jia YJ; Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 400042, China., Yuan ZY; Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 400042, China., Yu ZY; Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 400042, China., Shi AY; Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 400042, China., Zeng GH; Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 400042, China., Wang J; Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 400042, China., Wang WY; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 201210, China., Cheng L; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Victoria, 3086, Australia., Vella LJ; The Florey Institute, The University of Melbourne, Parkville, Victoria, 3052, Australia., Li FZ; Carrier Biomed (Suzhou) Co., Ltd., Suzhou, 215000, China., Masters CL; The Florey Institute, The University of Melbourne, Parkville, Victoria, 3052, Australia. c.masters@florey.edu.au., Wang YJ; Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China. yanjiang_wang@tmmu.edu.cn.; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 400042, China. yanjiang_wang@tmmu.edu.cn.
Source: Science China. Life sciences [Sci China Life Sci] 2026 Apr 30. Date of Electronic Publication: 2026 Apr 30.
Publication Type: Journal Article
Journal Info: Publisher: Science China Press, co-published with Springer Country of Publication: China NLM ID: 101529880 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1869-1889 (Electronic) Linking ISSN: 16747305 NLM ISO Abbreviation: Sci China Life Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Proteomic comparison of human neural cell-derived extracellular vesicles and parental cells from Alzheimer's disease and cognitively normal individuals.
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  Data: <searchLink fieldCode="AU" term="%22Xin+JY%22">Xin JY</searchLink>; Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 400042, China.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 400042, China.; Department of Cognitive Impairment Research, Chongqing Institute for Brain and Intelligence, Guangyang Bay Laboratory, Chongqing, 401336, China.<br /><searchLink fieldCode="AU" term="%22Dong+HM%22">Dong HM</searchLink>; Department of Cognitive Impairment Research, Chongqing Institute for Brain and Intelligence, Guangyang Bay Laboratory, Chongqing, 401336, China.<br /><searchLink fieldCode="AU" term="%22Yu+HL%22">Yu HL</searchLink>; Carrier Biomed (Suzhou) Co., Ltd., Suzhou, 215000, China.<br /><searchLink fieldCode="AU" term="%22Xiao+ZS%22">Xiao ZS</searchLink>; Department of Cognitive Impairment Research, Chongqing Institute for Brain and Intelligence, Guangyang Bay Laboratory, Chongqing, 401336, China.<br /><searchLink fieldCode="AU" term="%22Hu+JN%22">Hu JN</searchLink>; Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 400042, China.<br /><searchLink fieldCode="AU" term="%22Jiang+Q%22">Jiang Q</searchLink>; Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 400042, China.<br /><searchLink fieldCode="AU" term="%22Zhu+YP%22">Zhu YP</searchLink>; Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 400042, China.<br /><searchLink fieldCode="AU" term="%22Feng+L%22">Feng L</searchLink>; Department of Cognitive Impairment Research, Chongqing Institute for Brain and Intelligence, Guangyang Bay Laboratory, Chongqing, 401336, China.<br /><searchLink fieldCode="AU" term="%22Feng+Y%22">Feng Y</searchLink>; Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 400042, China.<br /><searchLink fieldCode="AU" term="%22Jia+YJ%22">Jia YJ</searchLink>; Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 400042, China.<br /><searchLink fieldCode="AU" term="%22Yuan+ZY%22">Yuan ZY</searchLink>; Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 400042, China.<br /><searchLink fieldCode="AU" term="%22Yu+ZY%22">Yu ZY</searchLink>; Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 400042, China.<br /><searchLink fieldCode="AU" term="%22Shi+AY%22">Shi AY</searchLink>; Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 400042, China.<br /><searchLink fieldCode="AU" term="%22Zeng+GH%22">Zeng GH</searchLink>; Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 400042, China.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 400042, China.<br /><searchLink fieldCode="AU" term="%22Wang+WY%22">Wang WY</searchLink>; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 201210, China.<br /><searchLink fieldCode="AU" term="%22Cheng+L%22">Cheng L</searchLink>; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Victoria, 3086, Australia.<br /><searchLink fieldCode="AU" term="%22Vella+LJ%22">Vella LJ</searchLink>; The Florey Institute, The University of Melbourne, Parkville, Victoria, 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Li+FZ%22">Li FZ</searchLink>; Carrier Biomed (Suzhou) Co., Ltd., Suzhou, 215000, China.<br /><searchLink fieldCode="AU" term="%22Masters+CL%22">Masters CL</searchLink>; The Florey Institute, The University of Melbourne, Parkville, Victoria, 3052, Australia. c.masters@florey.edu.au.<br /><searchLink fieldCode="AU" term="%22Wang+YJ%22">Wang YJ</searchLink>; Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China. yanjiang_wang@tmmu.edu.cn.; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 400042, China. yanjiang_wang@tmmu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101529880%22">Science China. Life sciences</searchLink> [Sci China Life Sci] 2026 Apr 30. <i>Date of Electronic Publication: </i>2026 Apr 30.
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        Value: 10.1007/s11427-025-3243-2
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        Text: English
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              Text: 2026 Apr 30
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