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Design, synthesis, and multitarget evaluation of thiosemicarbazone-sulfonamide hybrids as potent cholinesterase and MAO-A inhibitors with neuroblastoma-associated cytotoxicity.

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Title: Design, synthesis, and multitarget evaluation of thiosemicarbazone-sulfonamide hybrids as potent cholinesterase and MAO-A inhibitors with neuroblastoma-associated cytotoxicity.
Authors: Abbas K; Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan., Elamin MR; Department of Chemistry, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia., Şenol H; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Bezmialem Vakif University, Fatih, 34093, Istanbul, Turkey., Çakır F; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Bezmialem Vakif University, Fatih, 34093, Istanbul, Turkey., Taslimi P; Department of Biotechnology, Faculty of Science, Bartin University, 74110, Bartin, Turkey., Tokali FS; Department of Material and Material Processing Technologies, Kars Vocational School, Kafkas University, 36100, Kars, Turkey., Raza N; Department of Chemistry, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia., Salem ME; Department of Chemistry, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia., Alharthy RD; Department of Chemistry, Rabigh Branch, Science & Arts College, King Abdulaziz University, Rabigh, 21911, Saudi Arabia., Rasool A; School of Chemistry and Chemical Engineering Nanjing university, Nanjing, 210093, China., Shafiq Z; Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan. zahidshafiq@bzu.edu.pk.
Source: Scientific reports [Sci Rep] 2026 May 11; Vol. 16 (1). Date of Electronic Publication: 2026 May 11.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Design, synthesis, and multitarget evaluation of thiosemicarbazone-sulfonamide hybrids as potent cholinesterase and MAO-A inhibitors with neuroblastoma-associated cytotoxicity.
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  Data: <searchLink fieldCode="AU" term="%22Abbas+K%22">Abbas K</searchLink>; Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan.<br /><searchLink fieldCode="AU" term="%22Elamin+MR%22">Elamin MR</searchLink>; Department of Chemistry, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Şenol+H%22">Şenol H</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Bezmialem Vakif University, Fatih, 34093, Istanbul, Turkey.<br /><searchLink fieldCode="AU" term="%22Çakır+F%22">Çakır F</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Bezmialem Vakif University, Fatih, 34093, Istanbul, Turkey.<br /><searchLink fieldCode="AU" term="%22Taslimi+P%22">Taslimi P</searchLink>; Department of Biotechnology, Faculty of Science, Bartin University, 74110, Bartin, Turkey.<br /><searchLink fieldCode="AU" term="%22Tokali+FS%22">Tokali FS</searchLink>; Department of Material and Material Processing Technologies, Kars Vocational School, Kafkas University, 36100, Kars, Turkey.<br /><searchLink fieldCode="AU" term="%22Raza+N%22">Raza N</searchLink>; Department of Chemistry, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Salem+ME%22">Salem ME</searchLink>; Department of Chemistry, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Alharthy+RD%22">Alharthy RD</searchLink>; Department of Chemistry, Rabigh Branch, Science & Arts College, King Abdulaziz University, Rabigh, 21911, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Rasool+A%22">Rasool A</searchLink>; School of Chemistry and Chemical Engineering Nanjing university, Nanjing, 210093, China.<br /><searchLink fieldCode="AU" term="%22Shafiq+Z%22">Shafiq Z</searchLink>; Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan. zahidshafiq@bzu.edu.pk.
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  Data: <searchLink fieldCode="JN" term="%22101563288%22">Scientific reports</searchLink> [Sci Rep] 2026 May 11; Vol. 16 (1). <i>Date of Electronic Publication: </i>2026 May 11.
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              Text: 2026 May 11
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