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Targeting dihydroorotate dehydrogenase (hDHODH) beyond the barrier: discovery of MEDS700 as blood-brain barrier permeable hDHODH inhibitor.

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Title: Targeting dihydroorotate dehydrogenase (hDHODH) beyond the barrier: discovery of MEDS700 as blood-brain barrier permeable hDHODH inhibitor.
Authors: Sainas S; Department of Drug Science and Technology, University of Turin, Via P. Giuria 9, Turin, 10125, Italy; Drug Discovery and Clinic s.r.l., Via Gioacchino Quarello 15/A, Torino, 10135, Italy., Vigato C; Department of Drug Science and Technology, University of Turin, Via P. Giuria 9, Turin, 10125, Italy., Circosta P; Drug Discovery and Clinic s.r.l., Via Gioacchino Quarello 15/A, Torino, 10135, Italy; Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, Orbassano, Turin, 10043, Italy; Molecular Biotechnology Center, University of Turin, Via Nizza 52, Turin, 10126, Italy., Zonfrillo M; Translational Pharmacology Institute of Rome (IFT), Research National Council (CNR), Via Fosso del Cavaliere 100, Rome, 00133, Italy., Servidei T; Pediatric Oncology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy., Alberti M; Department of Pharmaceutical Sciences, University of Piemonte Orientale, Via G. Bovio 6, Novara, 28100, Italy., Rescigno M; Translational Pharmacology Institute of Rome (IFT), Research National Council (CNR), Via Fosso del Cavaliere 100, Rome, 00133, Italy., Miggiano R; Department of Pharmaceutical Sciences, University of Piemonte Orientale, Via G. Bovio 6, Novara, 28100, Italy., Gaidano V; Division of Hematology and Cell Therapy, AO Ordine Mauriziano, Largo Filippo Turati, 62, Turin, 10128, Italy., Vitale N; Department of Molecular Biotechnologies and Health Science, University of Turin, Via Nizza 52, Turin, 10126, Italy., Passoni A; Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, Milan, 20156, Italy., Lanno A; Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, Milan, 20156, Italy., Buccinnà B; Department of Oncology, University of Turin, Via Michelangelo Buonarroti 27/B, Turin, 10125, Italy., Piccinini M; Department of Oncology, University of Turin, Via Michelangelo Buonarroti 27/B, Turin, 10125, Italy., Lorenzati M; Department of Neuroscience Rita Levi-Montalcini, University of Torino, Via Cherasco 15, Torino, 10126, Italy; Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Torino, Regione Gonzole 43, Orbassano, 10043, Italy., Gentile S; Pediatric Oncology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy., Sferrazza G; Department of Biomedical Sciences, Research National Council (CNR), Piazzale Aldo Moro 7, Rome, 00185, Italy., Sgambato A; Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, 00168, Italy; Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, 00168, Italy., Saglio G; Drug Discovery and Clinic s.r.l., Via Gioacchino Quarello 15/A, Torino, 10135, Italy., Giorgis M; Department of Drug Science and Technology, University of Turin, Via P. Giuria 9, Turin, 10125, Italy; Drug Discovery and Clinic s.r.l., Via Gioacchino Quarello 15/A, Torino, 10135, Italy., Boschi D; Department of Drug Science and Technology, University of Turin, Via P. Giuria 9, Turin, 10125, Italy; Drug Discovery and Clinic s.r.l., Via Gioacchino Quarello 15/A, Torino, 10135, Italy., Lolli ML; Department of Drug Science and Technology, University of Turin, Via P. Giuria 9, Turin, 10125, Italy; Drug Discovery and Clinic s.r.l., Via Gioacchino Quarello 15/A, Torino, 10135, Italy. Electronic address: marco.lolli@unito.it.
Source: European journal of medicinal chemistry [Eur J Med Chem] 2026 Sep 15; Vol. 314, pp. 118896. Date of Electronic Publication: 2026 Apr 27.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE
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  Data: Targeting dihydroorotate dehydrogenase (hDHODH) beyond the barrier: discovery of MEDS700 as blood-brain barrier permeable hDHODH inhibitor.
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  Data: <searchLink fieldCode="AU" term="%22Sainas+S%22">Sainas S</searchLink>; Department of Drug Science and Technology, University of Turin, Via P. Giuria 9, Turin, 10125, Italy; Drug Discovery and Clinic s.r.l., Via Gioacchino Quarello 15/A, Torino, 10135, Italy.<br /><searchLink fieldCode="AU" term="%22Vigato+C%22">Vigato C</searchLink>; Department of Drug Science and Technology, University of Turin, Via P. Giuria 9, Turin, 10125, Italy.<br /><searchLink fieldCode="AU" term="%22Circosta+P%22">Circosta P</searchLink>; Drug Discovery and Clinic s.r.l., Via Gioacchino Quarello 15/A, Torino, 10135, Italy; Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, Orbassano, Turin, 10043, Italy; Molecular Biotechnology Center, University of Turin, Via Nizza 52, Turin, 10126, Italy.<br /><searchLink fieldCode="AU" term="%22Zonfrillo+M%22">Zonfrillo M</searchLink>; Translational Pharmacology Institute of Rome (IFT), Research National Council (CNR), Via Fosso del Cavaliere 100, Rome, 00133, Italy.<br /><searchLink fieldCode="AU" term="%22Servidei+T%22">Servidei T</searchLink>; Pediatric Oncology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Alberti+M%22">Alberti M</searchLink>; Department of Pharmaceutical Sciences, University of Piemonte Orientale, Via G. Bovio 6, Novara, 28100, Italy.<br /><searchLink fieldCode="AU" term="%22Rescigno+M%22">Rescigno M</searchLink>; Translational Pharmacology Institute of Rome (IFT), Research National Council (CNR), Via Fosso del Cavaliere 100, Rome, 00133, Italy.<br /><searchLink fieldCode="AU" term="%22Miggiano+R%22">Miggiano R</searchLink>; Department of Pharmaceutical Sciences, University of Piemonte Orientale, Via G. Bovio 6, Novara, 28100, Italy.<br /><searchLink fieldCode="AU" term="%22Gaidano+V%22">Gaidano V</searchLink>; Division of Hematology and Cell Therapy, AO Ordine Mauriziano, Largo Filippo Turati, 62, Turin, 10128, Italy.<br /><searchLink fieldCode="AU" term="%22Vitale+N%22">Vitale N</searchLink>; Department of Molecular Biotechnologies and Health Science, University of Turin, Via Nizza 52, Turin, 10126, Italy.<br /><searchLink fieldCode="AU" term="%22Passoni+A%22">Passoni A</searchLink>; Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, Milan, 20156, Italy.<br /><searchLink fieldCode="AU" term="%22Lanno+A%22">Lanno A</searchLink>; Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, Milan, 20156, Italy.<br /><searchLink fieldCode="AU" term="%22Buccinnà+B%22">Buccinnà B</searchLink>; Department of Oncology, University of Turin, Via Michelangelo Buonarroti 27/B, Turin, 10125, Italy.<br /><searchLink fieldCode="AU" term="%22Piccinini+M%22">Piccinini M</searchLink>; Department of Oncology, University of Turin, Via Michelangelo Buonarroti 27/B, Turin, 10125, Italy.<br /><searchLink fieldCode="AU" term="%22Lorenzati+M%22">Lorenzati M</searchLink>; Department of Neuroscience Rita Levi-Montalcini, University of Torino, Via Cherasco 15, Torino, 10126, Italy; Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Torino, Regione Gonzole 43, Orbassano, 10043, Italy.<br /><searchLink fieldCode="AU" term="%22Gentile+S%22">Gentile S</searchLink>; Pediatric Oncology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Sferrazza+G%22">Sferrazza G</searchLink>; Department of Biomedical Sciences, Research National Council (CNR), Piazzale Aldo Moro 7, Rome, 00185, Italy.<br /><searchLink fieldCode="AU" term="%22Sgambato+A%22">Sgambato A</searchLink>; Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, 00168, Italy; Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, 00168, Italy.<br /><searchLink fieldCode="AU" term="%22Saglio+G%22">Saglio G</searchLink>; Drug Discovery and Clinic s.r.l., Via Gioacchino Quarello 15/A, Torino, 10135, Italy.<br /><searchLink fieldCode="AU" term="%22Giorgis+M%22">Giorgis M</searchLink>; Department of Drug Science and Technology, University of Turin, Via P. Giuria 9, Turin, 10125, Italy; Drug Discovery and Clinic s.r.l., Via Gioacchino Quarello 15/A, Torino, 10135, Italy.<br /><searchLink fieldCode="AU" term="%22Boschi+D%22">Boschi D</searchLink>; Department of Drug Science and Technology, University of Turin, Via P. Giuria 9, Turin, 10125, Italy; Drug Discovery and Clinic s.r.l., Via Gioacchino Quarello 15/A, Torino, 10135, Italy.<br /><searchLink fieldCode="AU" term="%22Lolli+ML%22">Lolli ML</searchLink>; Department of Drug Science and Technology, University of Turin, Via P. Giuria 9, Turin, 10125, Italy; Drug Discovery and Clinic s.r.l., Via Gioacchino Quarello 15/A, Torino, 10135, Italy. Electronic address: marco.lolli@unito.it.
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