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Tirzepatide for maintenance of bodyweight reduction in people with obesity in the USA (SURMOUNT-MAINTAIN): a multicentre, double-blind, randomised, placebo-controlled trial.

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Title: Tirzepatide for maintenance of bodyweight reduction in people with obesity in the USA (SURMOUNT-MAINTAIN): a multicentre, double-blind, randomised, placebo-controlled trial.
Authors: Horn DB; Center for Obesity Medicine and Metabolic Performance, Departments of Surgery and Internal Medicine, University of Texas McGovern Medical School, Houston, TX, USA., Aronne LJ; Comprehensive Weight Control Center, Division of Endocrinology, Diabetes, and Metabolism, Weill Cornell Medicine, New York, NY, USA., Wharton S; Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Wharton Weight Management Clinic, Toronto, ON, Canada., Bays HE; Monroe Biomedical Research, Louisville Metabolic and Atherosclerosis Research Center, Louisville, KY, USA., le Roux CW; Diabetes Complications Research Centre, University College Dublin, Dublin, Ireland., Srinath R; Department of Medicine, Division of Endocrinology, Diabetes, and Bone Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Gomez-Valderas E; Eli Lilly, Indianapolis, IN, USA., Arad AD; Eli Lilly, Indianapolis, IN, USA., Das S; Eli Lilly, Indianapolis, IN, USA., Dunn JP; Eli Lilly, Indianapolis, IN, USA., Ribeiro A; Eli Lilly, Indianapolis, IN, USA., Glass LC; Eli Lilly, Indianapolis, IN, USA., Lee CJ; Eli Lilly, Indianapolis, IN, USA. Electronic address: clare.lee@lilly.com.
Source: Lancet (London, England) [Lancet] 2026 Jun 06; Vol. 407 (10545), pp. 2305-2318. Date of Electronic Publication: 2026 May 12.
Publication Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Clinical Trial, Phase III
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 2985213R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-547X (Electronic) Linking ISSN: 01406736 NLM ISO Abbreviation: Lancet Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Tirzepatide for maintenance of bodyweight reduction in people with obesity in the USA (SURMOUNT-MAINTAIN): a multicentre, double-blind, randomised, placebo-controlled trial.
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  Data: <searchLink fieldCode="AU" term="%22Horn+DB%22">Horn DB</searchLink>; Center for Obesity Medicine and Metabolic Performance, Departments of Surgery and Internal Medicine, University of Texas McGovern Medical School, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Aronne+LJ%22">Aronne LJ</searchLink>; Comprehensive Weight Control Center, Division of Endocrinology, Diabetes, and Metabolism, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Wharton+S%22">Wharton S</searchLink>; Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Wharton Weight Management Clinic, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Bays+HE%22">Bays HE</searchLink>; Monroe Biomedical Research, Louisville Metabolic and Atherosclerosis Research Center, Louisville, KY, USA.<br /><searchLink fieldCode="AU" term="%22le+Roux+CW%22">le Roux CW</searchLink>; Diabetes Complications Research Centre, University College Dublin, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Srinath+R%22">Srinath R</searchLink>; Department of Medicine, Division of Endocrinology, Diabetes, and Bone Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Gomez-Valderas+E%22">Gomez-Valderas E</searchLink>; Eli Lilly, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Arad+AD%22">Arad AD</searchLink>; Eli Lilly, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Das+S%22">Das S</searchLink>; Eli Lilly, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Dunn+JP%22">Dunn JP</searchLink>; Eli Lilly, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Ribeiro+A%22">Ribeiro A</searchLink>; Eli Lilly, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Glass+LC%22">Glass LC</searchLink>; Eli Lilly, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Lee+CJ%22">Lee CJ</searchLink>; Eli Lilly, Indianapolis, IN, USA. Electronic address: clare.lee@lilly.com.
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  Data: <searchLink fieldCode="JN" term="%222985213R%22">Lancet (London, England)</searchLink> [Lancet] 2026 Jun 06; Vol. 407 (10545), pp. 2305-2318. <i>Date of Electronic Publication: </i>2026 May 12.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>2985213R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1474-547X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201406736%22">01406736 </searchLink><i>NLM ISO Abbreviation: </i>Lancet <i>Subsets: </i>MEDLINE
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              Text: 2026 Jun 06
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