TMPRSS2-ERG confers resistance of prostate cancer to antiandrogens.

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Title: TMPRSS2-ERG confers resistance of prostate cancer to antiandrogens.
Authors: Sekar A; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel., Selvadurai BR; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel., Chatterjee R; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel., Pal L; Cancer Data Science Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Verma A; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel., Belugali Nataraj N; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel.; Bugworks Research Inc, C-CAMP, NCBS Campus, Bangalore, India., Drago Garcia D; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel.; The Francis Crick Institute, London, UK., Giri S; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel., Genna A; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel., Karatekin F; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel.; National University of Singapore, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore., Gupta N; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel., Ramesh-Kumar D; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel., Zerbib M; Department of Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel., Vinik Y; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Avioz T; Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel., Weizman E; Department of Genomics Unit, Weizmann Institute of Science, Rehovot, Israel., David E; Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel., Schäffer AA; Cancer Data Science Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Pan Y; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA., Huang H; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA., van Weerden WM; Department of Urology, Erasmus University Medical Center, Rotterdam, The Netherlands., Corey E; Department of Urology, University of Washington School of Medicine, Seattle, WA, USA., Hunt H; Corcept Therapeutics, Menlo Park, CA, USA., Greenstein AE; Exelixis, Inc., 1851 Harbor Bay Pkwy, Alameda, CA, USA., Blecher-Gonen R; Department of Genomics Unit, Weizmann Institute of Science, Rehovot, Israel., Oren R; Department of Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel., Afek A; Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel., Amit I; Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel., Lev S; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Ku A; Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Kartal S; Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., R Bright J; Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., T Lis R; Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., L Dahut W; Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Sowalsky AG; Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Ruppin E; Cancer Data Science Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Yarden Y; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel. yosef.yarden@weizmann.ac.il.
Source: EMBO molecular medicine [EMBO Mol Med] 2026 Jun; Vol. 18 (6), pp. 2062-2097. Date of Electronic Publication: 2026 May 12.
Publication Type: Journal Article
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE
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  Data: TMPRSS2-ERG confers resistance of prostate cancer to antiandrogens.
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Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Kartal+S%22">Kartal S</searchLink>; Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22R+Bright+J%22">R Bright J</searchLink>; Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22T+Lis+R%22">T Lis R</searchLink>; Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22L+Dahut+W%22">L Dahut W</searchLink>; Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Sowalsky+AG%22">Sowalsky AG</searchLink>; 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