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CCDC174 deficiency impaired human fertility by affecting the alternative splicing of maternal mRNAs.

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Title: CCDC174 deficiency impaired human fertility by affecting the alternative splicing of maternal mRNAs.
Authors: Wang W; International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. wangweijie0816@126.com., Pan Z; Institute of Pediatrics, Children's Hospital of Fudan University, The Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China., Jing H; Institute of Pediatrics, Children's Hospital of Fudan University, The Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China., Shi R; Reproductive Medicine Center, Shaanxi Maternal and Child Care Service Center, Xi'an, China., Wu L; Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Wang J; Institute of Pediatrics, Children's Hospital of Fudan University, The Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China., Chen B; Institute of Pediatrics, Children's Hospital of Fudan University, The Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China., Mu J; Institute of Pediatrics, Children's Hospital of Fudan University, The Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China., Zhang Z; Institute of Pediatrics, Children's Hospital of Fudan University, The Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China., Wu T; Institute of Pediatrics, Children's Hospital of Fudan University, The Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China., Li Q; Institute of Pediatrics, Children's Hospital of Fudan University, The Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China., Shi J; Reproductive Medicine Center, Shaanxi Maternal and Child Care Service Center, Xi'an, China., Kuang Y; Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., He L; Bio-X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China., Wang L; Institute of Pediatrics, Children's Hospital of Fudan University, The Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China. wangleiwanglei@fudan.edu.cn.; Shanghai Academy of Natural Sciences (SANS), Fudan University, Shanghai, China. wangleiwanglei@fudan.edu.cn., Sang Q; Institute of Pediatrics, Children's Hospital of Fudan University, The Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China. sangqing@fudan.edu.cn.
Source: EMBO molecular medicine [EMBO Mol Med] 2026 Jun; Vol. 18 (6), pp. 2436-2454. Date of Electronic Publication: 2026 May 12.
Publication Type: Journal Article
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: CCDC174 deficiency impaired human fertility by affecting the alternative splicing of maternal mRNAs.
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  Data: <searchLink fieldCode="AU" term="%22Wang+W%22">Wang W</searchLink>; International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. wangweijie0816@126.com.<br /><searchLink fieldCode="AU" term="%22Pan+Z%22">Pan Z</searchLink>; Institute of Pediatrics, Children's Hospital of Fudan University, The Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Jing+H%22">Jing H</searchLink>; Institute of Pediatrics, Children's Hospital of Fudan University, The Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Shi+R%22">Shi R</searchLink>; Reproductive Medicine Center, Shaanxi Maternal and Child Care Service Center, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Wu+L%22">Wu L</searchLink>; Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Institute of Pediatrics, Children's Hospital of Fudan University, The Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Chen+B%22">Chen B</searchLink>; Institute of Pediatrics, Children's Hospital of Fudan University, The Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Mu+J%22">Mu J</searchLink>; Institute of Pediatrics, Children's Hospital of Fudan University, The Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; Institute of Pediatrics, Children's Hospital of Fudan University, The Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wu+T%22">Wu T</searchLink>; Institute of Pediatrics, Children's Hospital of Fudan University, The Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Li+Q%22">Li Q</searchLink>; Institute of Pediatrics, Children's Hospital of Fudan University, The Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Shi+J%22">Shi J</searchLink>; Reproductive Medicine Center, Shaanxi Maternal and Child Care Service Center, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Kuang+Y%22">Kuang Y</searchLink>; Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22He+L%22">He L</searchLink>; Bio-X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Institute of Pediatrics, Children's Hospital of Fudan University, The Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China. wangleiwanglei@fudan.edu.cn.; Shanghai Academy of Natural Sciences (SANS), Fudan University, Shanghai, China. wangleiwanglei@fudan.edu.cn.<br /><searchLink fieldCode="AU" term="%22Sang+Q%22">Sang Q</searchLink>; Institute of Pediatrics, Children's Hospital of Fudan University, The Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China. sangqing@fudan.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101487380%22">EMBO molecular medicine</searchLink> [EMBO Mol Med] 2026 Jun; Vol. 18 (6), pp. 2436-2454. <i>Date of Electronic Publication: </i>2026 May 12.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22EMBO+Press%22">EMBO Press </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>101487380 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1757-4684 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217574676%22">17574676 </searchLink><i>NLM ISO Abbreviation: </i>EMBO Mol Med <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s44321-026-00448-y
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        Text: English
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        StartPage: 2436
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      – TitleFull: CCDC174 deficiency impaired human fertility by affecting the alternative splicing of maternal mRNAs.
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              Text: 2026 Jun
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