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mSWI/SNF complex inhibition sensitizes KRAS-mutant lung cancers to targeted therapies via epithelial-mesenchymal subversion.

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Title: mSWI/SNF complex inhibition sensitizes KRAS-mutant lung cancers to targeted therapies via epithelial-mesenchymal subversion.
Authors: Gentile C; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA 02215.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Feng WW; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Lenahan SM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Ying AW; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA 02215.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Card DC; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA 02215.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Wu FTH; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Clinician Investigator Program, University of British Columbia, Vancouver, BC, Canada., Pham NA; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Radulovich N; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Cao PM; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Hueniken K; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Li Q; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Tsao MS; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, ON, Canada., Kulesza J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Hinkley MM; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA 02215.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Liao L; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Tsai JA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Köhler J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Facchinetti F; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Li J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Weston C; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Locquet MA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Ngo K; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA, USA., Gokhale PC; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA, USA., Sacher AG; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Immunology, University of Toronto, ON, Canada., Jänne PA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA, USA., Kadoch C; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA 02215.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Mar 01. Date of Electronic Publication: 2026 Mar 01.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: mSWI/SNF complex inhibition sensitizes KRAS-mutant lung cancers to targeted therapies via epithelial-mesenchymal subversion.
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  Data: <searchLink fieldCode="AU" term="%22Gentile+C%22">Gentile C</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA 02215.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Feng+WW%22">Feng WW</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lenahan+SM%22">Lenahan SM</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ying+AW%22">Ying AW</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA 02215.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Card+DC%22">Card DC</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA 02215.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wu+FTH%22">Wu FTH</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Clinician Investigator Program, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Pham+NA%22">Pham NA</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Radulovich+N%22">Radulovich N</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Cao+PM%22">Cao PM</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Hueniken+K%22">Hueniken K</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Li+Q%22">Li Q</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Tsao+MS%22">Tsao MS</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Kulesza+J%22">Kulesza J</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hinkley+MM%22">Hinkley MM</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA 02215.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Liao+L%22">Liao L</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Tsai+JA%22">Tsai JA</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Köhler+J%22">Köhler J</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Facchinetti+F%22">Facchinetti F</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Weston+C%22">Weston C</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Locquet+MA%22">Locquet MA</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ngo+K%22">Ngo K</searchLink>; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Gokhale+PC%22">Gokhale PC</searchLink>; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sacher+AG%22">Sacher AG</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Immunology, University of Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Jänne+PA%22">Jänne PA</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kadoch+C%22">Kadoch C</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA 02215.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA.
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