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Optogenetic WNT signaling drives germ layer self-organization in a human gastruloid model.

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Title: Optogenetic WNT signaling drives germ layer self-organization in a human gastruloid model.
Authors: Johnson HJ; Department of Bioengineering, University of California, Berkeley; Berkeley, California, 94720, USA.; Graduate Program in Bioengineering, University of California, San Francisco and University of California, Berkeley; Berkeley, California, 94720, USA., McMullin DM; Department of Bioengineering, University of California, Berkeley; Berkeley, California, 94720, USA.; Graduate Program in Bioengineering, University of California, San Francisco and University of California, Berkeley; Berkeley, California, 94720, USA.; Center for Computational Biology, University of California, Berkeley; Berkeley California, 94720., Zimmermann JA; Department of Chemical and Biomolecular Engineering, University of California, Berkeley; Berkeley, California, 94720, USA., Kim CN; Department of Anatomy, University of California, San Francisco; San Francisco, CA, 94158, USA.; Department of Psychiatry, University of California, San Francisco; San Francisco, CA, 94158, USA.; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco; San Francisco, CA, 94158, USA., Repina NA; Department of Bioengineering, University of California, Berkeley; Berkeley, California, 94720, USA.; Graduate Program in Bioengineering, University of California, San Francisco and University of California, Berkeley; Berkeley, California, 94720, USA., Bhalerao R; Department of Bioengineering, University of California, Berkeley; Berkeley, California, 94720, USA., Nowakowski TJ; Department of Anatomy, University of California, San Francisco; San Francisco, CA, 94158, USA.; Department of Psychiatry, University of California, San Francisco; San Francisco, CA, 94158, USA.; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco; San Francisco, CA, 94158, USA., Schaffer DV; Department of Bioengineering, University of California, Berkeley; Berkeley, California, 94720, USA.; Department of Chemical and Biomolecular Engineering, University of California, Berkeley; Berkeley, California, 94720, USA.; Helen Wills Neuroscience Institute, University of California, Berkeley; Berkeley, California, 94720, USA.; Department of Molecular and Cell Biology, University of California, Berkeley; Berkeley, California, 94720, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Feb 25. Date of Electronic Publication: 2026 Feb 25.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Optogenetic WNT signaling drives germ layer self-organization in a human gastruloid model.
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  Data: <searchLink fieldCode="AU" term="%22Johnson+HJ%22">Johnson HJ</searchLink>; Department of Bioengineering, University of California, Berkeley; Berkeley, California, 94720, USA.; Graduate Program in Bioengineering, University of California, San Francisco and University of California, Berkeley; Berkeley, California, 94720, USA.<br /><searchLink fieldCode="AU" term="%22McMullin+DM%22">McMullin DM</searchLink>; Department of Bioengineering, University of California, Berkeley; Berkeley, California, 94720, USA.; Graduate Program in Bioengineering, University of California, San Francisco and University of California, Berkeley; Berkeley, California, 94720, USA.; Center for Computational Biology, University of California, Berkeley; Berkeley California, 94720.<br /><searchLink fieldCode="AU" term="%22Zimmermann+JA%22">Zimmermann JA</searchLink>; Department of Chemical and Biomolecular Engineering, University of California, Berkeley; Berkeley, California, 94720, USA.<br /><searchLink fieldCode="AU" term="%22Kim+CN%22">Kim CN</searchLink>; Department of Anatomy, University of California, San Francisco; San Francisco, CA, 94158, USA.; Department of Psychiatry, University of California, San Francisco; San Francisco, CA, 94158, USA.; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco; San Francisco, CA, 94158, USA.<br /><searchLink fieldCode="AU" term="%22Repina+NA%22">Repina NA</searchLink>; Department of Bioengineering, University of California, Berkeley; Berkeley, California, 94720, USA.; Graduate Program in Bioengineering, University of California, San Francisco and University of California, Berkeley; Berkeley, California, 94720, USA.<br /><searchLink fieldCode="AU" term="%22Bhalerao+R%22">Bhalerao R</searchLink>; Department of Bioengineering, University of California, Berkeley; Berkeley, California, 94720, USA.<br /><searchLink fieldCode="AU" term="%22Nowakowski+TJ%22">Nowakowski TJ</searchLink>; Department of Anatomy, University of California, San Francisco; San Francisco, CA, 94158, USA.; Department of Psychiatry, University of California, San Francisco; San Francisco, CA, 94158, USA.; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco; San Francisco, CA, 94158, USA.<br /><searchLink fieldCode="AU" term="%22Schaffer+DV%22">Schaffer DV</searchLink>; Department of Bioengineering, University of California, Berkeley; Berkeley, California, 94720, USA.; Department of Chemical and Biomolecular Engineering, University of California, Berkeley; Berkeley, California, 94720, USA.; Helen Wills Neuroscience Institute, University of California, Berkeley; Berkeley, California, 94720, USA.; Department of Molecular and Cell Biology, University of California, Berkeley; Berkeley, California, 94720, USA.
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  Data: <searchLink fieldCode="JN" term="%22101680187%22">BioRxiv : the preprint server for biology</searchLink> [bioRxiv] 2026 Feb 25. <i>Date of Electronic Publication: </i>2026 Feb 25.
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        Value: 10.64898/2026.02.23.707602
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              Text: 2026 Feb 25
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