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Human pannexin mutations and their implications in erosive osteoarthritis.

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Title: Human pannexin mutations and their implications in erosive osteoarthritis.
Authors: Tang J; Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5C1, Canada.; Western Bone and Joint Institute, The Dr. Sandy Kirkley Centre for Musculoskeletal Research, University Hospital, London, ON N6G 2V4, Canada., Lu J; Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5C1, Canada.; Western Bone and Joint Institute, The Dr. Sandy Kirkley Centre for Musculoskeletal Research, University Hospital, London, ON N6G 2V4, Canada., Johnston D; Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5C1, Canada., Hoshijima K; Department of Orthopedics School of Medicine, University of Utah, Salt Lake City, UT 84113., Wakefield B; Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5C1, Canada.; Western Bone and Joint Institute, The Dr. Sandy Kirkley Centre for Musculoskeletal Research, University Hospital, London, ON N6G 2V4, Canada., Bai D; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5C1, Canada., Stathopulos PB; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5C1, Canada., Thompson RJ; Department of Cell Biology and Anatomy, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada., Lohman AW; Department of Cell Biology and Anatomy, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada., Jurynec MJ; Department of Orthopedics School of Medicine, University of Utah, Salt Lake City, UT 84113., Beier F; Western Bone and Joint Institute, The Dr. Sandy Kirkley Centre for Musculoskeletal Research, University Hospital, London, ON N6G 2V4, Canada.; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5C1, Canada., Penuela S; Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5C1, Canada.; Western Bone and Joint Institute, The Dr. Sandy Kirkley Centre for Musculoskeletal Research, University Hospital, London, ON N6G 2V4, Canada.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 May 19; Vol. 123 (20), pp. e2535302123. Date of Electronic Publication: 2026 May 13.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Tang+J%22">Tang J</searchLink>; Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5C1, Canada.; Western Bone and Joint Institute, The Dr. Sandy Kirkley Centre for Musculoskeletal Research, University Hospital, London, ON N6G 2V4, Canada.<br /><searchLink fieldCode="AU" term="%22Lu+J%22">Lu J</searchLink>; Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5C1, Canada.; Western Bone and Joint Institute, The Dr. Sandy Kirkley Centre for Musculoskeletal Research, University Hospital, London, ON N6G 2V4, Canada.<br /><searchLink fieldCode="AU" term="%22Johnston+D%22">Johnston D</searchLink>; Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5C1, Canada.<br /><searchLink fieldCode="AU" term="%22Hoshijima+K%22">Hoshijima K</searchLink>; Department of Orthopedics School of Medicine, University of Utah, Salt Lake City, UT 84113.<br /><searchLink fieldCode="AU" term="%22Wakefield+B%22">Wakefield B</searchLink>; Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5C1, Canada.; Western Bone and Joint Institute, The Dr. Sandy Kirkley Centre for Musculoskeletal Research, University Hospital, London, ON N6G 2V4, Canada.<br /><searchLink fieldCode="AU" term="%22Bai+D%22">Bai D</searchLink>; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5C1, Canada.<br /><searchLink fieldCode="AU" term="%22Stathopulos+PB%22">Stathopulos PB</searchLink>; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5C1, Canada.<br /><searchLink fieldCode="AU" term="%22Thompson+RJ%22">Thompson RJ</searchLink>; Department of Cell Biology and Anatomy, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.<br /><searchLink fieldCode="AU" term="%22Lohman+AW%22">Lohman AW</searchLink>; Department of Cell Biology and Anatomy, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.<br /><searchLink fieldCode="AU" term="%22Jurynec+MJ%22">Jurynec MJ</searchLink>; Department of Orthopedics School of Medicine, University of Utah, Salt Lake City, UT 84113.<br /><searchLink fieldCode="AU" term="%22Beier+F%22">Beier F</searchLink>; Western Bone and Joint Institute, The Dr. Sandy Kirkley Centre for Musculoskeletal Research, University Hospital, London, ON N6G 2V4, Canada.; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5C1, Canada.<br /><searchLink fieldCode="AU" term="%22Penuela+S%22">Penuela S</searchLink>; Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5C1, Canada.; Western Bone and Joint Institute, The Dr. Sandy Kirkley Centre for Musculoskeletal Research, University Hospital, London, ON N6G 2V4, Canada.
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