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High-throughput screening approach identifies substrate-selective Hsp104 variants that counter amyloid seeding with diminished off-target effects.

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Title: High-throughput screening approach identifies substrate-selective Hsp104 variants that counter amyloid seeding with diminished off-target effects.
Authors: Ryan JJ; Department of Chemistry, Washington University, St. Louis, MO 63130, USA., Miller KR; Department of Chemistry, Washington University, St. Louis, MO 63130, USA., Puri A; Department of Chemistry, Washington University, St. Louis, MO 63130, USA., Sprunger ML; Department of Chemistry, Washington University, St. Louis, MO 63130, USA., Bochantine MM; Department of Chemistry, Washington University, St. Louis, MO 63130, USA., Lopez A; Department of Chemistry, Washington University, St. Louis, MO 63130, USA., Chen S; Department of Chemistry, Washington University, St. Louis, MO 63130, USA., Bao A; Department of Chemistry, Washington University, St. Louis, MO 63130, USA., Ling C; Department of Chemistry, Washington University, St. Louis, MO 63130, USA., Xu A; Department of Chemistry, Washington University, St. Louis, MO 63130, USA., Bell B; Department of Chemistry, Washington University, St. Louis, MO 63130, USA., Sohn BS; Department of Chemistry, Washington University, St. Louis, MO 63130, USA., Li L; Department of Chemistry, Washington University, St. Louis, MO 63130, USA., Chang C; Department of Chemistry, Washington University, St. Louis, MO 63130, USA., Mohammed K; Department of Chemistry, Washington University, St. Louis, MO 63130, USA., Staller MV; Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA., Jackrel ME; Department of Chemistry, Washington University, St. Louis, MO 63130, USA. Electronic address: mjackrel@wustl.edu.
Source: Molecular cell [Mol Cell] 2026 May 21; Vol. 86 (10), pp. 2012-2030.e11. Date of Electronic Publication: 2026 May 12.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE
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