Life-threatening hemorrhage from acquired factor V deficiency with non-inhibitory, hyperclearance-type antibodies successfully treated with rituximab then belimumab.

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Title: Life-threatening hemorrhage from acquired factor V deficiency with non-inhibitory, hyperclearance-type antibodies successfully treated with rituximab then belimumab.
Authors: Tanaka-Mabuchi N; Department of Rheumatology, University of Yamanashi, Faculty of Medicine, 1110 Shimokato, Chuo-shi, Yamanashi 409-3898, Japan., Hanai S; Department of Rheumatology, University of Yamanashi, Faculty of Medicine, 1110 Shimokato, Chuo-shi, Yamanashi 409-3898, Japan. Electronic address: shanai@yamanashi.ac.jp., Ito R; Department of Rheumatology, University of Yamanashi, Faculty of Medicine, 1110 Shimokato, Chuo-shi, Yamanashi 409-3898, Japan., Kubota S; Department of Rheumatology, University of Yamanashi, Faculty of Medicine, 1110 Shimokato, Chuo-shi, Yamanashi 409-3898, Japan., Ikeda K; Department of Rheumatology, University of Yamanashi, Faculty of Medicine, 1110 Shimokato, Chuo-shi, Yamanashi 409-3898, Japan., Yazaki M; Department of Rheumatology, University of Yamanashi, Faculty of Medicine, 1110 Shimokato, Chuo-shi, Yamanashi 409-3898, Japan., Kobayashi Y; Department of Rheumatology, University of Yamanashi, Faculty of Medicine, 1110 Shimokato, Chuo-shi, Yamanashi 409-3898, Japan., Takamino J; Department of Emergency and Critical Care Medicine, University of Yamanashi, Faculty of Medicine, 1110 Shimokato, Chuo-shi, Yamanashi 409-3898, Japan., Takano K; Division of Transfusion Medicine and Cell Therapy, University of Yamanashi Hospital, 1110 Shimokato, Chuo-shi, Yamanashi 409-3898, Japan., Ieko M; Department of Nursing, Faculty of Health and Medical Sciences, Sapporo University of Health Sciences, 1-15, Nakanuma Nishi 4-2, Higashi-ku, Sapporo 007-0894, Japan., Hashiguchi T; Department of Laboratory and Vascular Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan., Nakagomi D; Department of Rheumatology, University of Yamanashi, Faculty of Medicine, 1110 Shimokato, Chuo-shi, Yamanashi 409-3898, Japan.
Source: Joint bone spine [Joint Bone Spine] 2026 May 12; Vol. 93 (5), pp. 106077. Date of Electronic Publication: 2026 May 12.
Publication Type: Case Reports; Journal Article
Journal Info: Publisher: Editions Elsevier Country of Publication: France NLM ID: 100938016 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1778-7254 (Electronic) Linking ISSN: 1297319X NLM ISO Abbreviation: Joint Bone Spine Subsets: MEDLINE
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  Data: Life-threatening hemorrhage from acquired factor V deficiency with non-inhibitory, hyperclearance-type antibodies successfully treated with rituximab then belimumab.
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  Data: <searchLink fieldCode="AU" term="%22Tanaka-Mabuchi+N%22">Tanaka-Mabuchi N</searchLink>; Department of Rheumatology, University of Yamanashi, Faculty of Medicine, 1110 Shimokato, Chuo-shi, Yamanashi 409-3898, Japan.<br /><searchLink fieldCode="AU" term="%22Hanai+S%22">Hanai S</searchLink>; Department of Rheumatology, University of Yamanashi, Faculty of Medicine, 1110 Shimokato, Chuo-shi, Yamanashi 409-3898, Japan. Electronic address: shanai@yamanashi.ac.jp.<br /><searchLink fieldCode="AU" term="%22Ito+R%22">Ito R</searchLink>; Department of Rheumatology, University of Yamanashi, Faculty of Medicine, 1110 Shimokato, Chuo-shi, Yamanashi 409-3898, Japan.<br /><searchLink fieldCode="AU" term="%22Kubota+S%22">Kubota S</searchLink>; Department of Rheumatology, University of Yamanashi, Faculty of Medicine, 1110 Shimokato, Chuo-shi, Yamanashi 409-3898, Japan.<br /><searchLink fieldCode="AU" term="%22Ikeda+K%22">Ikeda K</searchLink>; Department of Rheumatology, University of Yamanashi, Faculty of Medicine, 1110 Shimokato, Chuo-shi, Yamanashi 409-3898, Japan.<br /><searchLink fieldCode="AU" term="%22Yazaki+M%22">Yazaki M</searchLink>; Department of Rheumatology, University of Yamanashi, Faculty of Medicine, 1110 Shimokato, Chuo-shi, Yamanashi 409-3898, Japan.<br /><searchLink fieldCode="AU" term="%22Kobayashi+Y%22">Kobayashi Y</searchLink>; Department of Rheumatology, University of Yamanashi, Faculty of Medicine, 1110 Shimokato, Chuo-shi, Yamanashi 409-3898, Japan.<br /><searchLink fieldCode="AU" term="%22Takamino+J%22">Takamino J</searchLink>; Department of Emergency and Critical Care Medicine, University of Yamanashi, Faculty of Medicine, 1110 Shimokato, Chuo-shi, Yamanashi 409-3898, Japan.<br /><searchLink fieldCode="AU" term="%22Takano+K%22">Takano K</searchLink>; Division of Transfusion Medicine and Cell Therapy, University of Yamanashi Hospital, 1110 Shimokato, Chuo-shi, Yamanashi 409-3898, Japan.<br /><searchLink fieldCode="AU" term="%22Ieko+M%22">Ieko M</searchLink>; Department of Nursing, Faculty of Health and Medical Sciences, Sapporo University of Health Sciences, 1-15, Nakanuma Nishi 4-2, Higashi-ku, Sapporo 007-0894, Japan.<br /><searchLink fieldCode="AU" term="%22Hashiguchi+T%22">Hashiguchi T</searchLink>; Department of Laboratory and Vascular Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan.<br /><searchLink fieldCode="AU" term="%22Nakagomi+D%22">Nakagomi D</searchLink>; Department of Rheumatology, University of Yamanashi, Faculty of Medicine, 1110 Shimokato, Chuo-shi, Yamanashi 409-3898, Japan.
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  Data: <searchLink fieldCode="JN" term="%22100938016%22">Joint bone spine</searchLink> [Joint Bone Spine] 2026 May 12; Vol. 93 (5), pp. 106077. <i>Date of Electronic Publication: </i>2026 May 12.
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