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Methemoglobin Formation Reflects Systemic Nitric Oxide Uptake: The Critical Role of Delivery Method-Results from Secondary Analysis of a Randomized Controlled Trial.

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Title: Methemoglobin Formation Reflects Systemic Nitric Oxide Uptake: The Critical Role of Delivery Method-Results from Secondary Analysis of a Randomized Controlled Trial.
Authors: Cenci S; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA; Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA., Gaonkar M; Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL., Villalobos R; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA., Medeiros KJ; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA; Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA., Shetty N; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA; Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA., Nardini R; Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA., Carroll RW; Division of Pediatric Critical Care, Department of Pediatrics, Massachusetts General Hospital for Children, Boston, MA; Harvard Medical School, Boston, MA., Bittner EA; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Boston, MA., Winkler T; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Boston, MA., Yu B; Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Boston, MA., Lewandrowski KB; Harvard Medical School, Boston, MA; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA., Ichinose F; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA; Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Boston, MA., Arora P; Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL; Section of Cardiology, Birmingham Veterans Affairs Medical Center, Birmingham, AL., Berra L; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA; Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Boston, MA; Respiratory Care Department, Massachusetts General Hospital and Harvard Medical School, Boston, MA. Electronic address: lberra@mgh.harvard.edu.
Source: Journal of cardiothoracic and vascular anesthesia [J Cardiothorac Vasc Anesth] 2026 Apr 17. Date of Electronic Publication: 2026 Apr 17.
Publication Type: Journal Article
Journal Info: Publisher: W.B. Saunders Country of Publication: United States NLM ID: 9110208 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8422 (Electronic) Linking ISSN: 10530770 NLM ISO Abbreviation: J Cardiothorac Vasc Anesth Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Cenci+S%22">Cenci S</searchLink>; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA; Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Gaonkar+M%22">Gaonkar M</searchLink>; Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL.<br /><searchLink fieldCode="AU" term="%22Villalobos+R%22">Villalobos R</searchLink>; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Medeiros+KJ%22">Medeiros KJ</searchLink>; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA; Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Shetty+N%22">Shetty N</searchLink>; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA; Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Nardini+R%22">Nardini R</searchLink>; Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Carroll+RW%22">Carroll RW</searchLink>; Division of Pediatric Critical Care, Department of Pediatrics, Massachusetts General Hospital for Children, Boston, MA; Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Bittner+EA%22">Bittner EA</searchLink>; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Winkler+T%22">Winkler T</searchLink>; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Yu+B%22">Yu B</searchLink>; Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Lewandrowski+KB%22">Lewandrowski KB</searchLink>; Harvard Medical School, Boston, MA; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Ichinose+F%22">Ichinose F</searchLink>; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA; Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Arora+P%22">Arora P</searchLink>; Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL; Section of Cardiology, Birmingham Veterans Affairs Medical Center, Birmingham, AL.<br /><searchLink fieldCode="AU" term="%22Berra+L%22">Berra L</searchLink>; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA; Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Boston, MA; Respiratory Care Department, Massachusetts General Hospital and Harvard Medical School, Boston, MA. Electronic address: lberra@mgh.harvard.edu.
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        Value: 10.1053/j.jvca.2026.04.029
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      – TitleFull: Methemoglobin Formation Reflects Systemic Nitric Oxide Uptake: The Critical Role of Delivery Method-Results from Secondary Analysis of a Randomized Controlled Trial.
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