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Clozapine disrupts the gut-lung microbiota axis, linking gastrointestinal hypomotility to increased respiratory vulnerability.

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Title: Clozapine disrupts the gut-lung microbiota axis, linking gastrointestinal hypomotility to increased respiratory vulnerability.
Authors: Cai Y; Chiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan.; Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260-8675, Japan., Eguchi A; Department of Sustainable Health Science, Chiba University Center for Preventive Medical Sciences, Chiba, 263-8522, Japan., Murayama R; Chiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan.; Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260-8675, Japan., Ding X; Chiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan.; Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China., Yue Y; Chiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan.; Department of Pharmacology, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan., Niitsu T; Department of Psychiatry, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan., Oda Y; Department of Psychiatry, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan., Futamura T; Department of CNS Research, Otsuka Pharmaceutical Co., Ltd., Tokushima, 771-0192, Japan., Yang JJ; Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.; Department of Anesthesiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China., Nakamura H; Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260-8675, Japan., Hashimoto K; Chiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan. hashimoto@faculty.chiba-u.jp.; Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. hashimoto@faculty.chiba-u.jp.; Basic Medicine Research Innovation Center for Cardiometabolic Diseases, Ministry of Education, Southwest Medical University, Luzhou, 646000, Sichuan, China. hashimoto@faculty.chiba-u.jp.
Source: Translational psychiatry [Transl Psychiatry] 2026 May 14. Date of Electronic Publication: 2026 May 14.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Cai+Y%22">Cai Y</searchLink>; Chiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan.; Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260-8675, Japan.<br /><searchLink fieldCode="AU" term="%22Eguchi+A%22">Eguchi A</searchLink>; Department of Sustainable Health Science, Chiba University Center for Preventive Medical Sciences, Chiba, 263-8522, Japan.<br /><searchLink fieldCode="AU" term="%22Murayama+R%22">Murayama R</searchLink>; Chiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan.; Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260-8675, Japan.<br /><searchLink fieldCode="AU" term="%22Ding+X%22">Ding X</searchLink>; Chiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan.; Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.<br /><searchLink fieldCode="AU" term="%22Yue+Y%22">Yue Y</searchLink>; Chiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan.; Department of Pharmacology, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.<br /><searchLink fieldCode="AU" term="%22Niitsu+T%22">Niitsu T</searchLink>; Department of Psychiatry, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.<br /><searchLink fieldCode="AU" term="%22Oda+Y%22">Oda Y</searchLink>; Department of Psychiatry, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.<br /><searchLink fieldCode="AU" term="%22Futamura+T%22">Futamura T</searchLink>; Department of CNS Research, Otsuka Pharmaceutical Co., Ltd., Tokushima, 771-0192, Japan.<br /><searchLink fieldCode="AU" term="%22Yang+JJ%22">Yang JJ</searchLink>; Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.; Department of Anesthesiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.<br /><searchLink fieldCode="AU" term="%22Nakamura+H%22">Nakamura H</searchLink>; Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260-8675, Japan.<br /><searchLink fieldCode="AU" term="%22Hashimoto+K%22">Hashimoto K</searchLink>; Chiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan. hashimoto@faculty.chiba-u.jp.; Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. hashimoto@faculty.chiba-u.jp.; Basic Medicine Research Innovation Center for Cardiometabolic Diseases, Ministry of Education, Southwest Medical University, Luzhou, 646000, Sichuan, China. hashimoto@faculty.chiba-u.jp.
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