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Oral supplementation with piceatannol improves skin hydration and reduces wrinkle severity: a randomized, double-blind, placebo-controlled trial.

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Title: Oral supplementation with piceatannol improves skin hydration and reduces wrinkle severity: a randomized, double-blind, placebo-controlled trial.
Authors: Seto Y; R&D Institute, Morinaga & Co., Ltd., Yokohama, Japan., Tsukiashi M; R&D Institute, Morinaga & Co., Ltd., Yokohama, Japan., Yamaguchi T; R&D Institute, Morinaga & Co., Ltd., Yokohama, Japan., Kawakami S; R&D Institute, Morinaga & Co., Ltd., Yokohama, Japan., Maruki-Uchida H; R&D Institute, Morinaga & Co., Ltd., Yokohama, Japan., Nishimura E; R&D Institute, Morinaga & Co., Ltd., Yokohama, Japan., Mori S; R&D Institute, Morinaga & Co., Ltd., Yokohama, Japan., Ito M; R&D Institute, Morinaga & Co., Ltd., Yokohama, Japan., Jin K; Nihonbashi Ueda Clinic, Tokyo, Japan., Maeda K; Tokyo University of Technology, Tokyo, Japan., Iemoto N; R&D Institute, Morinaga & Co., Ltd., Yokohama, Japan.
Source: Frontiers in nutrition [Front Nutr] 2026 Apr 28; Vol. 13, pp. 1765478. Date of Electronic Publication: 2026 Apr 28 (Print Publication: 2026).
Publication Type: Clinical Trial; Journal Article
Journal Info: Publisher: Frontiers Media S. A Country of Publication: Switzerland NLM ID: 101642264 Publication Model: eCollection Cited Medium: Print ISSN: 2296-861X (Print) Linking ISSN: 2296861X NLM ISO Abbreviation: Front Nutr Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Oral supplementation with piceatannol improves skin hydration and reduces wrinkle severity: a randomized, double-blind, placebo-controlled trial.
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  Data: <searchLink fieldCode="AU" term="%22Seto+Y%22">Seto Y</searchLink>; R&D Institute, Morinaga & Co., Ltd., Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Tsukiashi+M%22">Tsukiashi M</searchLink>; R&D Institute, Morinaga & Co., Ltd., Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Yamaguchi+T%22">Yamaguchi T</searchLink>; R&D Institute, Morinaga & Co., Ltd., Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Kawakami+S%22">Kawakami S</searchLink>; R&D Institute, Morinaga & Co., Ltd., Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Maruki-Uchida+H%22">Maruki-Uchida H</searchLink>; R&D Institute, Morinaga & Co., Ltd., Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Nishimura+E%22">Nishimura E</searchLink>; R&D Institute, Morinaga & Co., Ltd., Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Mori+S%22">Mori S</searchLink>; R&D Institute, Morinaga & Co., Ltd., Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Ito+M%22">Ito M</searchLink>; R&D Institute, Morinaga & Co., Ltd., Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Jin+K%22">Jin K</searchLink>; Nihonbashi Ueda Clinic, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Maeda+K%22">Maeda K</searchLink>; Tokyo University of Technology, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Iemoto+N%22">Iemoto N</searchLink>; R&D Institute, Morinaga & Co., Ltd., Yokohama, Japan.
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  Data: <searchLink fieldCode="JN" term="%22101642264%22">Frontiers in nutrition</searchLink> [Front Nutr] 2026 Apr 28; Vol. 13, pp. 1765478. <i>Date of Electronic Publication: </i>2026 Apr 28 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Media+S%2E+A%22">Frontiers Media S. A </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101642264 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>2296-861X (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222296861X%22">2296861X </searchLink><i>NLM ISO Abbreviation: </i>Front Nutr <i>Subsets: </i>PubMed not MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42131241
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        Value: 10.3389/fnut.2026.1765478
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        Text: English
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      – TitleFull: Oral supplementation with piceatannol improves skin hydration and reduces wrinkle severity: a randomized, double-blind, placebo-controlled trial.
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              Text: 2026 Apr 28
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