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Marine-derived surfactin derivatives suppress collagen production and interfere with the HSP47-collagen interaction in preclinical models.

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Title: Marine-derived surfactin derivatives suppress collagen production and interfere with the HSP47-collagen interaction in preclinical models.
Authors: Okuno D; Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan., Sakamoto N; Department of Respiratory Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan., Akiyama Y; Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan., Iketani C; Department of Respiratory Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan., Murakami R; Department of Respiratory Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan., Miyamura T; Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan., Yura H; Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan., Kido T; Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan., Ishimoto H; Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan., Ishimatsu Y; Department of Nursing, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan., Taniguchi H; Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan.; Clinical Oncology Center, Nagasaki University Hospital, Nagasaki, Japan., Fukahori S; Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan., Takemoto S; Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan., Takazono T; Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan., Nishino T; Department of Nephrology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Ishihara J; Department of Pharmaceutical Organic Chemistry, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Takouda J; Department of Cell Regulation, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Takeda K; Department of Cell Regulation, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Tanaka Y; Center for Medical Innovation, Nagasaki University, Nagasaki, Japan., Mukae H; Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan.; Department of Respiratory Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Source: Frontiers in pharmacology [Front Pharmacol] 2026 Apr 28; Vol. 17, pp. 1809175. Date of Electronic Publication: 2026 Apr 28 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Marine-derived surfactin derivatives suppress collagen production and interfere with the HSP47-collagen interaction in preclinical models.
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  Data: <searchLink fieldCode="AU" term="%22Okuno+D%22">Okuno D</searchLink>; Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Sakamoto+N%22">Sakamoto N</searchLink>; Department of Respiratory Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Akiyama+Y%22">Akiyama Y</searchLink>; Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Iketani+C%22">Iketani C</searchLink>; Department of Respiratory Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Murakami+R%22">Murakami R</searchLink>; Department of Respiratory Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Miyamura+T%22">Miyamura T</searchLink>; Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Yura+H%22">Yura H</searchLink>; Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Kido+T%22">Kido T</searchLink>; Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Ishimoto+H%22">Ishimoto H</searchLink>; Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Ishimatsu+Y%22">Ishimatsu Y</searchLink>; Department of Nursing, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Taniguchi+H%22">Taniguchi H</searchLink>; Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan.; Clinical Oncology Center, Nagasaki University Hospital, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Fukahori+S%22">Fukahori S</searchLink>; Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Takemoto+S%22">Takemoto S</searchLink>; Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Takazono+T%22">Takazono T</searchLink>; Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Nishino+T%22">Nishino T</searchLink>; Department of Nephrology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Ishihara+J%22">Ishihara J</searchLink>; Department of Pharmaceutical Organic Chemistry, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Takouda+J%22">Takouda J</searchLink>; Department of Cell Regulation, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Takeda+K%22">Takeda K</searchLink>; Department of Cell Regulation, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Tanaka+Y%22">Tanaka Y</searchLink>; Center for Medical Innovation, Nagasaki University, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Mukae+H%22">Mukae H</searchLink>; Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan.; Department of Respiratory Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
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  Data: <searchLink fieldCode="JN" term="%22101548923%22">Frontiers in pharmacology</searchLink> [Front Pharmacol] 2026 Apr 28; Vol. 17, pp. 1809175. <i>Date of Electronic Publication: </i>2026 Apr 28 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Media]%22">Frontiers Media] </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101548923 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>1663-9812 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216639812%22">16639812 </searchLink><i>NLM ISO Abbreviation: </i>Front Pharmacol <i>Subsets: </i>PubMed not MEDLINE
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