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Structural decomposition enables multi-omics dissection of common and organ-specific aging.

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Title: Structural decomposition enables multi-omics dissection of common and organ-specific aging.
Authors: Huang H; Ministry of Education Key Laboratory of Contemporary Anthropology, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai, 200438, China.; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China., Li Y; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China., Song Q; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China., Yuan L; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China., Yang Y; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China., Zhu M; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China., Sun R; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China., Hu Y; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China., Xiong C; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China., Ni T; State Key Laboratory of Genetic Engineering, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Collaborative Innovation Center of Genetics and Development, Human Phenome Institute, Center for Evolutionary Biology, Shanghai Engineering Research Center of Industrial Microorganisms, School of Life Sciences, Fudan University, Shanghai, 200438, China., Liu Y; MOE Key Laboratory of Metabolism and Molecular Medicine, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China., Ruiz-Linares A; Ministry of Education Key Laboratory of Contemporary Anthropology, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai, 200438, China.; EFS, Anthropologie Bio-Culturelle, Droit, Ethique et Santé (ADES), Aix-Marseille Université, Centre National de la Recherche Scientifique (CNRS), Marseille, 13000, France.; Department of Genetics, Evolution and Environment, and UCL Genetics Institute, University College London, London, WC1E 6BT, UK., Zhang G; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China., Liu F; Department of Forensic Sciences, College of Criminal Justice, Naif Arab University of Security Sciences, Riyadh, 11452, Kingdom of Saudi Arabia. fliu@nauss.edu.sa., Peng Q; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China. pengqianqian@sinh.ac.cn., Wang S; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China. wangsijia@sinh.ac.cn.
Source: Science China. Life sciences [Sci China Life Sci] 2026 May 08. Date of Electronic Publication: 2026 May 08.
Publication Type: Journal Article
Journal Info: Publisher: Science China Press, co-published with Springer Country of Publication: China NLM ID: 101529880 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1869-1889 (Electronic) Linking ISSN: 16747305 NLM ISO Abbreviation: Sci China Life Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Structural decomposition enables multi-omics dissection of common and organ-specific aging.
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  Data: <searchLink fieldCode="AU" term="%22Huang+H%22">Huang H</searchLink>; Ministry of Education Key Laboratory of Contemporary Anthropology, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai, 200438, China.; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.<br /><searchLink fieldCode="AU" term="%22Song+Q%22">Song Q</searchLink>; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.<br /><searchLink fieldCode="AU" term="%22Yuan+L%22">Yuan L</searchLink>; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.<br /><searchLink fieldCode="AU" term="%22Yang+Y%22">Yang Y</searchLink>; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.<br /><searchLink fieldCode="AU" term="%22Zhu+M%22">Zhu M</searchLink>; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.<br /><searchLink fieldCode="AU" term="%22Sun+R%22">Sun R</searchLink>; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.<br /><searchLink fieldCode="AU" term="%22Hu+Y%22">Hu Y</searchLink>; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.<br /><searchLink fieldCode="AU" term="%22Xiong+C%22">Xiong C</searchLink>; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.<br /><searchLink fieldCode="AU" term="%22Ni+T%22">Ni T</searchLink>; State Key Laboratory of Genetic Engineering, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Collaborative Innovation Center of Genetics and Development, Human Phenome Institute, Center for Evolutionary Biology, Shanghai Engineering Research Center of Industrial Microorganisms, School of Life Sciences, Fudan University, Shanghai, 200438, China.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; MOE Key Laboratory of Metabolism and Molecular Medicine, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.<br /><searchLink fieldCode="AU" term="%22Ruiz-Linares+A%22">Ruiz-Linares A</searchLink>; Ministry of Education Key Laboratory of Contemporary Anthropology, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai, 200438, China.; EFS, Anthropologie Bio-Culturelle, Droit, Ethique et Santé (ADES), Aix-Marseille Université, Centre National de la Recherche Scientifique (CNRS), Marseille, 13000, France.; Department of Genetics, Evolution and Environment, and UCL Genetics Institute, University College London, London, WC1E 6BT, UK.<br /><searchLink fieldCode="AU" term="%22Zhang+G%22">Zhang G</searchLink>; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.<br /><searchLink fieldCode="AU" term="%22Liu+F%22">Liu F</searchLink>; Department of Forensic Sciences, College of Criminal Justice, Naif Arab University of Security Sciences, Riyadh, 11452, Kingdom of Saudi Arabia. fliu@nauss.edu.sa.<br /><searchLink fieldCode="AU" term="%22Peng+Q%22">Peng Q</searchLink>; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China. pengqianqian@sinh.ac.cn.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China. wangsijia@sinh.ac.cn.
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        Value: 10.1007/s11427-025-3242-5
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      – Code: eng
        Text: English
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              Text: 2026 May 08
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