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Antibody fine specificity correlates with protection from malaria for the RTS,S vaccine in young African children: A post hoc analysis of a phase IIb randomised controlled trial.

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Title: Antibody fine specificity correlates with protection from malaria for the RTS,S vaccine in young African children: A post hoc analysis of a phase IIb randomised controlled trial.
Authors: Hysa A; Burnet Institute, Melbourne, Australia.; Department of Infectious Diseases and Department of Medicine, The University of Melbourne, Melbourne, Australia., Opi DH; Burnet Institute, Melbourne, Australia.; Department of Infectious Diseases and Department of Medicine, The University of Melbourne, Melbourne, Australia.; School of Translational Medicine and Department of Microbiology, Monash University, Melbourne, Australia., Waterhouse J; Burnet Institute, Melbourne, Australia.; School of Translational Medicine and Department of Microbiology, Monash University, Melbourne, Australia., Chishimba S; Burnet Institute, Melbourne, Australia.; Department of Infectious Diseases and Department of Medicine, The University of Melbourne, Melbourne, Australia., Horton JL; Burnet Institute, Melbourne, Australia.; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, England, United Kingdom., Kingston N; Astbury Centre for Structural Molecular Biology, School of Molecular & Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom., Netter HJ; School of Science, RMIT University, Melbourne, Australia., Wetzel D; ARTES Biotechnology GmbH, Langenfeld, Germany., Piontek M; ARTES Biotechnology GmbH, Langenfeld, Germany.; Laboratory of Plant and Process Design, Technical University of Dortmund, Dortmund, Germany., Feng G; Burnet Institute, Melbourne, Australia.; National Vaccine Innovation Platform, NHC Key Laboratory of Antibody Technique, Jiangsu Key Laboratory of Pathogen Biology, Department of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China., Sacarlal J; Centro de Investigação em Saúde de Manhiça, Maputo, Mozambique.; Faculdade de Medicina, Universidade Eduardo Mondlane (UEM), Maputo, Mozambique., Dobaño C; ISGlobal, Hospital Clínic Universitat de Barcelona, Barcelona, Catalonia, Spain.; SGlobal, Hospital Clínic Universitat de Barcelona, and Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Barcelona, Spain., Kurtovic L; Burnet Institute, Melbourne, Australia.; Department of Infectious Diseases and Department of Medicine, The University of Melbourne, Melbourne, Australia.; School of Translational Medicine and Department of Microbiology, Monash University, Melbourne, Australia., Beeson JG; Burnet Institute, Melbourne, Australia.; Department of Infectious Diseases and Department of Medicine, The University of Melbourne, Melbourne, Australia.; School of Translational Medicine and Department of Microbiology, Monash University, Melbourne, Australia.
Source: PLoS medicine [PLoS Med] 2026 May 14; Vol. 23 (5), pp. e1004877. Date of Electronic Publication: 2026 May 14 (Print Publication: 2026).
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101231360 Publication Model: eCollection Cited Medium: Internet ISSN: 1549-1676 (Electronic) Linking ISSN: 15491277 NLM ISO Abbreviation: PLoS Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Antibody fine specificity correlates with protection from malaria for the RTS,S vaccine in young African children: A post hoc analysis of a phase IIb randomised controlled trial.
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  Data: <searchLink fieldCode="AU" term="%22Hysa+A%22">Hysa A</searchLink>; Burnet Institute, Melbourne, Australia.; Department of Infectious Diseases and Department of Medicine, The University of Melbourne, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Opi+DH%22">Opi DH</searchLink>; Burnet Institute, Melbourne, Australia.; Department of Infectious Diseases and Department of Medicine, The University of Melbourne, Melbourne, Australia.; School of Translational Medicine and Department of Microbiology, Monash University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Waterhouse+J%22">Waterhouse J</searchLink>; Burnet Institute, Melbourne, Australia.; School of Translational Medicine and Department of Microbiology, Monash University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Chishimba+S%22">Chishimba S</searchLink>; Burnet Institute, Melbourne, Australia.; Department of Infectious Diseases and Department of Medicine, The University of Melbourne, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Horton+JL%22">Horton JL</searchLink>; Burnet Institute, Melbourne, Australia.; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, England, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Kingston+N%22">Kingston N</searchLink>; Astbury Centre for Structural Molecular Biology, School of Molecular & Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Netter+HJ%22">Netter HJ</searchLink>; School of Science, RMIT University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Wetzel+D%22">Wetzel D</searchLink>; ARTES Biotechnology GmbH, Langenfeld, Germany.<br /><searchLink fieldCode="AU" term="%22Piontek+M%22">Piontek M</searchLink>; ARTES Biotechnology GmbH, Langenfeld, Germany.; Laboratory of Plant and Process Design, Technical University of Dortmund, Dortmund, Germany.<br /><searchLink fieldCode="AU" term="%22Feng+G%22">Feng G</searchLink>; Burnet Institute, Melbourne, Australia.; National Vaccine Innovation Platform, NHC Key Laboratory of Antibody Technique, Jiangsu Key Laboratory of Pathogen Biology, Department of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Sacarlal+J%22">Sacarlal J</searchLink>; Centro de Investigação em Saúde de Manhiça, Maputo, Mozambique.; Faculdade de Medicina, Universidade Eduardo Mondlane (UEM), Maputo, Mozambique.<br /><searchLink fieldCode="AU" term="%22Dobaño+C%22">Dobaño C</searchLink>; ISGlobal, Hospital Clínic Universitat de Barcelona, Barcelona, Catalonia, Spain.; SGlobal, Hospital Clínic Universitat de Barcelona, and Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Kurtovic+L%22">Kurtovic L</searchLink>; Burnet Institute, Melbourne, Australia.; Department of Infectious Diseases and Department of Medicine, The University of Melbourne, Melbourne, Australia.; School of Translational Medicine and Department of Microbiology, Monash University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Beeson+JG%22">Beeson JG</searchLink>; Burnet Institute, Melbourne, Australia.; Department of Infectious Diseases and Department of Medicine, The University of Melbourne, Melbourne, Australia.; School of Translational Medicine and Department of Microbiology, Monash University, Melbourne, Australia.
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  Data: <searchLink fieldCode="JN" term="%22101231360%22">PLoS medicine</searchLink> [PLoS Med] 2026 May 14; Vol. 23 (5), pp. e1004877. <i>Date of Electronic Publication: </i>2026 May 14 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Public+Library+of+Science%22">Public Library of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101231360 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1549-1676 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215491277%22">15491277 </searchLink><i>NLM ISO Abbreviation: </i>PLoS Med <i>Subsets: </i>MEDLINE
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