Brain metabolomic profiling reveals ischemia-dominant disruption of metabolic pathways and tissue homeostasis in neonatal hypoxic-ischemic brain injury.
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| Title: | Brain metabolomic profiling reveals ischemia-dominant disruption of metabolic pathways and tissue homeostasis in neonatal hypoxic-ischemic brain injury. |
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| Authors: | Wolff N; Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Research Institute, Washington, DC, USA., Triantafyllou M; Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Research Institute, Washington, DC, USA., Ghaemmaghami J; Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Research Institute, Washington, DC, USA.; Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Sanidas G; Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Research Institute, Washington, DC, USA., Byrd CE; Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Research Institute, Washington, DC, USA., Simonti G; Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Research Institute, Washington, DC, USA., Aja S; Center for Metabolism and Obesity Research, Johns Hopkins School of Medicine, Baltimore, MD, USA., Roux A; Molecular Determinants Center and Core, Johns Hopkins All Children's Hospital, Saint Petersburg, FL, USA., Aziz K; Departments of Pediatrics, Division of Neonatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Goldstein E; Department of Biological Sciences, Augusta University, Augusta, GA, USA., Zhang J; Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, NY, USA., Everett AD; Department of Pediatrics, Blalock-Taussig-Thomas Congenital Heart Center, Johns Hopkins University, Baltimore, MD, USA., Graham D; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Kratimenos P; Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Research Institute, Washington, DC, USA.; Department of Pediatrics, Division of Neonatology, Children's National Hospital, Washington, DC, USA.; School of Medicine and Health Sciences, George Washington University, Washington, DC, USA., Koutroulis I; Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Research Institute, Washington, DC, USA. ikoutrouli@childrensnational.org.; School of Medicine and Health Sciences, George Washington University, Washington, DC, USA. ikoutrouli@childrensnational.org.; Department of Pediatrics, Division of Emergency Medicine, Children's National Hospital, Washington, DC, USA. ikoutrouli@childrensnational.org., Northington F; Departments of Pediatrics, Division of Neonatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. frances@jhmi.edu. |
| Source: | Scientific reports [Sci Rep] 2026 May 14. Date of Electronic Publication: 2026 May 14. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42135394 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Brain metabolomic profiling reveals ischemia-dominant disruption of metabolic pathways and tissue homeostasis in neonatal hypoxic-ischemic brain injury. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Wolff+N%22">Wolff N</searchLink>; Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Research Institute, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Triantafyllou+M%22">Triantafyllou M</searchLink>; Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Research Institute, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Ghaemmaghami+J%22">Ghaemmaghami J</searchLink>; Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Research Institute, Washington, DC, USA.; Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Sanidas+G%22">Sanidas G</searchLink>; Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Research Institute, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Byrd+CE%22">Byrd CE</searchLink>; Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Research Institute, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Simonti+G%22">Simonti G</searchLink>; Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Research Institute, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Aja+S%22">Aja S</searchLink>; Center for Metabolism and Obesity Research, Johns Hopkins School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Roux+A%22">Roux A</searchLink>; Molecular Determinants Center and Core, Johns Hopkins All Children's Hospital, Saint Petersburg, FL, USA.<br /><searchLink fieldCode="AU" term="%22Aziz+K%22">Aziz K</searchLink>; Departments of Pediatrics, Division of Neonatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Goldstein+E%22">Goldstein E</searchLink>; Department of Biological Sciences, Augusta University, Augusta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Everett+AD%22">Everett AD</searchLink>; Department of Pediatrics, Blalock-Taussig-Thomas Congenital Heart Center, Johns Hopkins University, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Graham+D%22">Graham D</searchLink>; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Kratimenos+P%22">Kratimenos P</searchLink>; Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Research Institute, Washington, DC, USA.; Department of Pediatrics, Division of Neonatology, Children's National Hospital, Washington, DC, USA.; School of Medicine and Health Sciences, George Washington University, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Koutroulis+I%22">Koutroulis I</searchLink>; Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Research Institute, Washington, DC, USA. ikoutrouli@childrensnational.org.; School of Medicine and Health Sciences, George Washington University, Washington, DC, USA. ikoutrouli@childrensnational.org.; Department of Pediatrics, Division of Emergency Medicine, Children's National Hospital, Washington, DC, USA. ikoutrouli@childrensnational.org.<br /><searchLink fieldCode="AU" term="%22Northington+F%22">Northington F</searchLink>; Departments of Pediatrics, Division of Neonatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. frances@jhmi.edu. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101563288%22">Scientific reports</searchLink> [Sci Rep] 2026 May 14. <i>Date of Electronic Publication: </i>2026 May 14. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101563288 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2045-2322 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220452322%22">20452322 </searchLink><i>NLM ISO Abbreviation: </i>Sci Rep <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42135394 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41598-026-51705-6 Languages: – Code: eng Text: English Titles: – TitleFull: Brain metabolomic profiling reveals ischemia-dominant disruption of metabolic pathways and tissue homeostasis in neonatal hypoxic-ischemic brain injury. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Wolff N – PersonEntity: Name: NameFull: Triantafyllou M – PersonEntity: Name: NameFull: Ghaemmaghami J – PersonEntity: Name: NameFull: Sanidas G – PersonEntity: Name: NameFull: Byrd CE – PersonEntity: Name: NameFull: Simonti G – PersonEntity: Name: NameFull: Aja S – PersonEntity: Name: NameFull: Roux A – PersonEntity: Name: NameFull: Aziz K – PersonEntity: Name: NameFull: Goldstein E – PersonEntity: Name: NameFull: Zhang J – PersonEntity: Name: NameFull: Everett AD – PersonEntity: Name: NameFull: Graham D – PersonEntity: Name: NameFull: Kratimenos P – PersonEntity: Name: NameFull: Koutroulis I – PersonEntity: Name: NameFull: Northington F IsPartOfRelationships: – BibEntity: Dates: – D: 14 M: 05 Text: 2026 May 14 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2045-2322 Titles: – TitleFull: Scientific reports Type: main |
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