Development of bicistronic plasmids and fusion proteins for clinical translation of tumor immune reprogramming.

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Title: Development of bicistronic plasmids and fusion proteins for clinical translation of tumor immune reprogramming.
Authors: Yang J; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.; Translational ImmunoEngineering Center, Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA., Chen SS; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.; Translational ImmunoEngineering Center, Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA., Idnani E; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.; Translational ImmunoEngineering Center, Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA., Shannon SR; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.; Translational ImmunoEngineering Center, Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA., Luly K; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.; Translational ImmunoEngineering Center, Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA., Fabilane CS; Translational ImmunoEngineering Center, Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA., Wilson DS; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.; Translational ImmunoEngineering Center, Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA., Spangler JB; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.; Translational ImmunoEngineering Center, Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.; Department of Chemical & Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.; Department of Oncology and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.; Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.; Department of Molecular Microbiology & Immunology, Johns Hopkins University School of Public Health, Baltimore, MD 21205, USA., Tzeng SY; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.; Translational ImmunoEngineering Center, Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA., Green JJ; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.; Translational ImmunoEngineering Center, Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.; Department of Chemical & Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.; Department of Oncology and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.; Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.; Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Materials Science & Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.; Institute for NanoBioTechnology and the Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD 21231, USA.
Source: Molecular therapy. Advances [Mol Ther Adv] 2026 Feb 28; Vol. 34 (2), pp. 201708. Date of Electronic Publication: 2026 Feb 28 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Country of Publication: United States NLM ID: 9919257804006676 Publication Model: eCollection Cited Medium: Print ISSN: 3117-387X (Print) Linking ISSN: 3117387X NLM ISO Abbreviation: Mol Ther Adv Subsets: PubMed not MEDLINE
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  Data: Development of bicistronic plasmids and fusion proteins for clinical translation of tumor immune reprogramming.
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  Data: <searchLink fieldCode="AU" term="%22Yang+J%22">Yang J</searchLink>; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.; Translational ImmunoEngineering Center, Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.<br /><searchLink fieldCode="AU" term="%22Chen+SS%22">Chen SS</searchLink>; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.; Translational ImmunoEngineering Center, Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.<br /><searchLink fieldCode="AU" term="%22Idnani+E%22">Idnani E</searchLink>; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.; Translational ImmunoEngineering Center, Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.<br /><searchLink fieldCode="AU" term="%22Shannon+SR%22">Shannon SR</searchLink>; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.; Translational ImmunoEngineering Center, Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.<br /><searchLink fieldCode="AU" term="%22Luly+K%22">Luly K</searchLink>; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.; Translational ImmunoEngineering Center, Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.<br /><searchLink fieldCode="AU" term="%22Fabilane+CS%22">Fabilane CS</searchLink>; Translational ImmunoEngineering Center, Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.<br /><searchLink fieldCode="AU" term="%22Wilson+DS%22">Wilson DS</searchLink>; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.; Translational ImmunoEngineering Center, Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.<br /><searchLink fieldCode="AU" term="%22Spangler+JB%22">Spangler JB</searchLink>; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.; Translational ImmunoEngineering Center, Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.; Department of Chemical & Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.; Department of Oncology and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.; Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.; Department of Molecular Microbiology & Immunology, Johns Hopkins University School of Public Health, Baltimore, MD 21205, USA.<br /><searchLink fieldCode="AU" term="%22Tzeng+SY%22">Tzeng SY</searchLink>; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.; Translational ImmunoEngineering Center, Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.<br /><searchLink fieldCode="AU" term="%22Green+JJ%22">Green JJ</searchLink>; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.; Translational ImmunoEngineering Center, Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.; Department of Chemical & Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.; Department of Oncology and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.; Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.; Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Materials Science & Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.; Institute for NanoBioTechnology and the Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD 21231, USA.
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  Data: <searchLink fieldCode="JN" term="%229919257804006676%22">Molecular therapy. Advances</searchLink> [Mol Ther Adv] 2026 Feb 28; Vol. 34 (2), pp. 201708. <i>Date of Electronic Publication: </i>2026 Feb 28 (<i>Print Publication: </i>2026).
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        Value: 10.1016/j.omta.2026.201708
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              Text: 2026 Feb 28
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