Targeting mGluR2/3 Signaling With LY341495 Restores Dentate Gyrus Function and Cognitive Performance in a Male Mouse Model of Alzheimer's Disease.

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Title: Targeting mGluR2/3 Signaling With LY341495 Restores Dentate Gyrus Function and Cognitive Performance in a Male Mouse Model of Alzheimer's Disease.
Authors: Chen CP; Cerebrovascular Disease Center, Ningbo Key Laboratory of Nervous System and Brain Function, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China., Zhang T; Department of Pharmacology, Health Science Center, Ningbo University, Ningbo, Zhejiang, China., E ED; Department of Pharmacology, Health Science Center, Ningbo University, Ningbo, Zhejiang, China., Xu TY; Department of Pharmacology, Health Science Center, Ningbo University, Ningbo, Zhejiang, China., Han Q; Cerebrovascular Disease Center, Ningbo Key Laboratory of Nervous System and Brain Function, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China., Gao X; Ningbo Key Laboratory of Nervous System and Brain Function, Department of Neurosurgery, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China., Sun J; Ningbo Key Laboratory of Nervous System and Brain Function, Department of Neurosurgery, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China., Huang Y; Ningbo Key Laboratory of Nervous System and Brain Function, Department of Neurosurgery, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China., Yang JH; Cerebrovascular Disease Center, Ningbo Key Laboratory of Nervous System and Brain Function, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China., Zhang XQ; Cerebrovascular Disease Center, Ningbo Key Laboratory of Nervous System and Brain Function, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.; Department of Pharmacology, Health Science Center, Ningbo University, Ningbo, Zhejiang, China.
Source: CNS neuroscience & therapeutics [CNS Neurosci Ther] 2026 May; Vol. 32 (5), pp. e70916.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101473265 Publication Model: Print Cited Medium: Internet ISSN: 1755-5949 (Electronic) Linking ISSN: 17555930 NLM ISO Abbreviation: CNS Neurosci Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Targeting mGluR2/3 Signaling With LY341495 Restores Dentate Gyrus Function and Cognitive Performance in a Male Mouse Model of Alzheimer's Disease.
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  Data: <searchLink fieldCode="AU" term="%22Chen+CP%22">Chen CP</searchLink>; Cerebrovascular Disease Center, Ningbo Key Laboratory of Nervous System and Brain Function, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Zhang+T%22">Zhang T</searchLink>; Department of Pharmacology, Health Science Center, Ningbo University, Ningbo, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22E+ED%22">E ED</searchLink>; Department of Pharmacology, Health Science Center, Ningbo University, Ningbo, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Xu+TY%22">Xu TY</searchLink>; Department of Pharmacology, Health Science Center, Ningbo University, Ningbo, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Han+Q%22">Han Q</searchLink>; Cerebrovascular Disease Center, Ningbo Key Laboratory of Nervous System and Brain Function, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Gao+X%22">Gao X</searchLink>; Ningbo Key Laboratory of Nervous System and Brain Function, Department of Neurosurgery, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Sun+J%22">Sun J</searchLink>; Ningbo Key Laboratory of Nervous System and Brain Function, Department of Neurosurgery, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Huang+Y%22">Huang Y</searchLink>; Ningbo Key Laboratory of Nervous System and Brain Function, Department of Neurosurgery, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Yang+JH%22">Yang JH</searchLink>; Cerebrovascular Disease Center, Ningbo Key Laboratory of Nervous System and Brain Function, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Zhang+XQ%22">Zhang XQ</searchLink>; Cerebrovascular Disease Center, Ningbo Key Laboratory of Nervous System and Brain Function, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.; Department of Pharmacology, Health Science Center, Ningbo University, Ningbo, Zhejiang, China.
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  Data: <searchLink fieldCode="JN" term="%22101473265%22">CNS neuroscience & therapeutics</searchLink> [CNS Neurosci Ther] 2026 May; Vol. 32 (5), pp. e70916.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley-Blackwell%22">Wiley-Blackwell </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101473265 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1755-5949 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217555930%22">17555930 </searchLink><i>NLM ISO Abbreviation: </i>CNS Neurosci Ther <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42138018
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        Value: 10.1002/cns.70916
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      – TitleFull: Targeting mGluR2/3 Signaling With LY341495 Restores Dentate Gyrus Function and Cognitive Performance in a Male Mouse Model of Alzheimer's Disease.
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            – D: 01
              M: 05
              Text: 2026 May
              Type: published
              Y: 2026
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