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Nanoliposomal myricetin attenuates diabetic testicular tissue injury and cellular dysfunction via coordinated modulation of PI3K/AKT/mTOR/SREBP-1c, Nrf2/HO-1, NF-κB, and caspase signaling pathways.

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Title: Nanoliposomal myricetin attenuates diabetic testicular tissue injury and cellular dysfunction via coordinated modulation of PI3K/AKT/mTOR/SREBP-1c, Nrf2/HO-1, NF-κB, and caspase signaling pathways.
Authors: Elmorsy EM; Center for Health Research, Northern Border University, P.O. Box 1321, Arar 91431, Saudi Arabia. Electronic address: Ekramy.elmorsy@nbu.edu.sa., Al-Ghafari AB; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Experimental Biochemistry Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Editome: Precision Gene Editing Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia. Electronic address: abalghafari@kau.edu.sa., Al Doghaither HA; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia. Electronic address: haldoghaither@kau.edu.sa., Jan M; Pharmacology Department, Faculty of Medicine, Northern Border University, P.O. Box 1321, Arar 91431, Saudi Arabia., Shah SSH; Pathology Department, Faculty of Medicine, Northern Border University, P.O. Box 1321, Arar 91431, Saudi Arabia. Electronic address: syed.shah@nbu.edu.sa., Syed A; Pathology Department, Faculty of Medicine, Northern Border University, P.O. Box 1321, Arar 91431, Saudi Arabia. Electronic address: asmara.Hussain@nbu.edu.sa., Marghani BH; Department of Physiology and Pharmacology, Faculty of Veterinary Medicine, King Salman International University, South of Sinai 46612, Egypt; Department of Physiology, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt. Electronic address: basma.hamed@Ksiu.edu.eg., Elshopakey GE; Department of Clinical Pathology, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt. Electronic address: gehadelshopakey@mans.edu.eg.
Source: Tissue & cell [Tissue Cell] 2026 May 12; Vol. 102, pp. 103608. Date of Electronic Publication: 2026 May 12.
Publication Type: Journal Article
Journal Info: Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 0214745 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3072 (Electronic) Linking ISSN: 00408166 NLM ISO Abbreviation: Tissue Cell Subsets: MEDLINE
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  Data: Nanoliposomal myricetin attenuates diabetic testicular tissue injury and cellular dysfunction via coordinated modulation of PI3K/AKT/mTOR/SREBP-1c, Nrf2/HO-1, NF-κB, and caspase signaling pathways.
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  Data: <searchLink fieldCode="AU" term="%22Elmorsy+EM%22">Elmorsy EM</searchLink>; Center for Health Research, Northern Border University, P.O. Box 1321, Arar 91431, Saudi Arabia. Electronic address: Ekramy.elmorsy@nbu.edu.sa.<br /><searchLink fieldCode="AU" term="%22Al-Ghafari+AB%22">Al-Ghafari AB</searchLink>; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Experimental Biochemistry Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Editome: Precision Gene Editing Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia. Electronic address: abalghafari@kau.edu.sa.<br /><searchLink fieldCode="AU" term="%22Al+Doghaither+HA%22">Al Doghaither HA</searchLink>; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia. Electronic address: haldoghaither@kau.edu.sa.<br /><searchLink fieldCode="AU" term="%22Jan+M%22">Jan M</searchLink>; Pharmacology Department, Faculty of Medicine, Northern Border University, P.O. Box 1321, Arar 91431, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Shah+SSH%22">Shah SSH</searchLink>; Pathology Department, Faculty of Medicine, Northern Border University, P.O. Box 1321, Arar 91431, Saudi Arabia. Electronic address: syed.shah@nbu.edu.sa.<br /><searchLink fieldCode="AU" term="%22Syed+A%22">Syed A</searchLink>; Pathology Department, Faculty of Medicine, Northern Border University, P.O. Box 1321, Arar 91431, Saudi Arabia. Electronic address: asmara.Hussain@nbu.edu.sa.<br /><searchLink fieldCode="AU" term="%22Marghani+BH%22">Marghani BH</searchLink>; Department of Physiology and Pharmacology, Faculty of Veterinary Medicine, King Salman International University, South of Sinai 46612, Egypt; Department of Physiology, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt. Electronic address: basma.hamed@Ksiu.edu.eg.<br /><searchLink fieldCode="AU" term="%22Elshopakey+GE%22">Elshopakey GE</searchLink>; Department of Clinical Pathology, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt. Electronic address: gehadelshopakey@mans.edu.eg.
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  Data: <searchLink fieldCode="JN" term="%220214745%22">Tissue & cell</searchLink> [Tissue Cell] 2026 May 12; Vol. 102, pp. 103608. <i>Date of Electronic Publication: </i>2026 May 12.
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              Text: 2026 May 12
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