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Matrix metalloproteinase-14 promotes LRP6 shedding in vascular smooth muscle cells and its expression is elevated in the tibial arteries from peripheral artery disease.

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Title: Matrix metalloproteinase-14 promotes LRP6 shedding in vascular smooth muscle cells and its expression is elevated in the tibial arteries from peripheral artery disease.
Authors: Chen HG; Department of Orthopedics, Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan, Guangdong 511518, China., Gao D; Department of Orthopedics, Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan, Guangdong 511518, China., Zeng GF; Department of Orthopedics, Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan, Guangdong 511518, China., Zhang GP; Department of Orthopedics, Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan, Guangdong 511518, China., Yuan ZY; Department of Orthopedics, Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan, Guangdong 511518, China., Pan DH; Department of Orthopedics, Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan, Guangdong 511518, China., Qin YK; Department of Orthopedics, Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan, Guangdong 511518, China., Lv ZY; Department of Orthopedics, Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan, Guangdong 511518, China., Tan XB; Department of Orthopedics, Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan, Guangdong 511518, China., Chen GT; Department of Orthopedics, Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan, Guangdong 511518, China., Wang GQ; Department of Orthopedics, Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan, Guangdong 511518, China. Electronic address: wangguiqing@gzhmu.edu.cn., Zhang DW; Department of Pediatrics and Group on the Molecular and Cell Biology of Lipids, University of Alberta, Alberta, Canada. Electronic address: dzhang@ualberta.ca., Xia XD; Department of Orthopedics, Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan, Guangdong 511518, China. Electronic address: xiaxiaodan1979@gzhmu.edu.cn.
Source: Biochimica et biophysica acta. General subjects [Biochim Biophys Acta Gen Subj] 2026 Aug; Vol. 1870 (8), pp. 130964. Date of Electronic Publication: 2026 May 14.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731726 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8006 (Electronic) Linking ISSN: 03044165 NLM ISO Abbreviation: Biochim Biophys Acta Gen Subj Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Matrix metalloproteinase-14 promotes LRP6 shedding in vascular smooth muscle cells and its expression is elevated in the tibial arteries from peripheral artery disease.
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  Data: <searchLink fieldCode="AU" term="%22Chen+HG%22">Chen HG</searchLink>; Department of Orthopedics, Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan, Guangdong 511518, China.<br /><searchLink fieldCode="AU" term="%22Gao+D%22">Gao D</searchLink>; Department of Orthopedics, Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan, Guangdong 511518, China.<br /><searchLink fieldCode="AU" term="%22Zeng+GF%22">Zeng GF</searchLink>; Department of Orthopedics, Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan, Guangdong 511518, China.<br /><searchLink fieldCode="AU" term="%22Zhang+GP%22">Zhang GP</searchLink>; Department of Orthopedics, Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan, Guangdong 511518, China.<br /><searchLink fieldCode="AU" term="%22Yuan+ZY%22">Yuan ZY</searchLink>; Department of Orthopedics, Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan, Guangdong 511518, China.<br /><searchLink fieldCode="AU" term="%22Pan+DH%22">Pan DH</searchLink>; Department of Orthopedics, Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan, Guangdong 511518, China.<br /><searchLink fieldCode="AU" term="%22Qin+YK%22">Qin YK</searchLink>; Department of Orthopedics, Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan, Guangdong 511518, China.<br /><searchLink fieldCode="AU" term="%22Lv+ZY%22">Lv ZY</searchLink>; Department of Orthopedics, Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan, Guangdong 511518, China.<br /><searchLink fieldCode="AU" term="%22Tan+XB%22">Tan XB</searchLink>; Department of Orthopedics, Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan, Guangdong 511518, China.<br /><searchLink fieldCode="AU" term="%22Chen+GT%22">Chen GT</searchLink>; Department of Orthopedics, Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan, Guangdong 511518, China.<br /><searchLink fieldCode="AU" term="%22Wang+GQ%22">Wang GQ</searchLink>; Department of Orthopedics, Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan, Guangdong 511518, China. Electronic address: wangguiqing@gzhmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhang+DW%22">Zhang DW</searchLink>; Department of Pediatrics and Group on the Molecular and Cell Biology of Lipids, University of Alberta, Alberta, Canada. Electronic address: dzhang@ualberta.ca.<br /><searchLink fieldCode="AU" term="%22Xia+XD%22">Xia XD</searchLink>; Department of Orthopedics, Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan, Guangdong 511518, China. Electronic address: xiaxiaodan1979@gzhmu.edu.cn.
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        Value: 10.1016/j.bbagen.2026.130964
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      – TitleFull: Matrix metalloproteinase-14 promotes LRP6 shedding in vascular smooth muscle cells and its expression is elevated in the tibial arteries from peripheral artery disease.
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              Text: 2026 Aug
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              Y: 2026
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