Quality over quantity: biopsy-anchored CT radiogenomics models outperform all-lesion training in a multi-tumour cohort despite a smaller sample size.

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Title: Quality over quantity: biopsy-anchored CT radiogenomics models outperform all-lesion training in a multi-tumour cohort despite a smaller sample size.
Authors: Rodríguez Sánchez DI; Department of Radiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; GROW Research Institute for Oncology and Reproduction, Maastricht University, Maastricht, The Netherlands., Middelkoop J; Department of Radiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Vanneste T; Department of Radiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Maxouri O; Department of Radiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; GROW Research Institute for Oncology and Reproduction, Maastricht University, Maastricht, The Netherlands., Ursprung S; Department of Radiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Radiology, University Hospital Tuebingen, Tuebingen, Germany., Rostami S; Department of Radiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; GROW Research Institute for Oncology and Reproduction, Maastricht University, Maastricht, The Netherlands., Bogveradze N; Department of Radiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; GROW Research Institute for Oncology and Reproduction, Maastricht University, Maastricht, The Netherlands.; Department of Radiology, American Hospital Tbilisi, Tbilisi, Georgia., Chupetlovska K; Department of Radiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; GROW Research Institute for Oncology and Reproduction, Maastricht University, Maastricht, The Netherlands., Castagnoli F; Department of Radiology, Royal Marsden Hospital, London, UK.; Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK., Landolfi F; Radiology Unit, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy., Hong EK; Department of Radiology, Stanford University, Palo Alto, CA, USA., Delli Pizzi A; Department of Innovative Technologies in Medicine & Dentistry, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy.; Institute for Advanced Biomedical Technologies, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy., Gennaro N; Feinberg School of Medicine, Northwestern University, NMH/Arkes Family Pavilion Suite 800, 676 N Saint Clair, Chicago, IL, 60611, USA.; Clinic of Radiology, Imaging Institute of Southern Switzerland (IIMSI), Ente Ospedaliero Cantonale (EOC), 6900, Lugano, Switzerland., Jutidamrongphan W; Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Petrychenko L; Department of Radiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; GROW Research Institute for Oncology and Reproduction, Maastricht University, Maastricht, The Netherlands., Snaebjornsson P; Department of Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Bodalal Z; Department of Radiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; GROW Research Institute for Oncology and Reproduction, Maastricht University, Maastricht, The Netherlands., Beets-Tan R; GROW Research Institute for Oncology and Reproduction, Maastricht University, Maastricht, The Netherlands. r.beetstan@maastrichtuniversity.nl.; The Netherlands Cancer Institute, Amsterdam, The Netherlands. r.beetstan@maastrichtuniversity.nl.; Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark. r.beetstan@maastrichtuniversity.nl.; Maastricht Radiation Oncology, Maastricht, The Netherlands. r.beetstan@maastrichtuniversity.nl.
Source: European radiology [Eur Radiol] 2026 May 16. Date of Electronic Publication: 2026 May 16.
Publication Type: Journal Article
Journal Info: Publisher: Springer International Country of Publication: Germany NLM ID: 9114774 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1084 (Electronic) Linking ISSN: 09387994 NLM ISO Abbreviation: Eur Radiol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1432-1084
DOI:10.1007/s00330-026-12601-9