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Lrp10 insufficiency upregulates mRNA and protein of neurotoxic α-synuclein and causes degeneration of substantia nigra dopaminergic neurons in heterozygous or homozygous Lrp10 knockout mice.

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Title: Lrp10 insufficiency upregulates mRNA and protein of neurotoxic α-synuclein and causes degeneration of substantia nigra dopaminergic neurons in heterozygous or homozygous Lrp10 knockout mice.
Authors: Wang HL; Department of Physiology and Pharmacology, Chang Gung University College of Medicine, Taoyuan, Taiwan; Division of Movement Disorders, Department of Neurology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Healthy Aging Research Center, Chang Gung University College of Medicine, Taoyuan, Taiwan; Neuroscience Research Center, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan., Liu SY; Department of Physiology and Pharmacology, Chang Gung University College of Medicine, Taoyuan, Taiwan., Chiu CC; Healthy Aging Research Center, Chang Gung University College of Medicine, Taoyuan, Taiwan; Neuroscience Research Center, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Department of Medical Biotechnology and Laboratory Science, Chang Gung University College of Medicine, Taoyuan, Taiwan., Yeh TH; Department of Neurology, Taipei Medical University Hospital, Taipei, Taiwan., Chiu TJ; Graduate Institute of Biomedical Sciences, Chang Gung University College of Medicine, Taoyuan, Taiwan., Yeh YC; Department of Physiology and Pharmacology, Chang Gung University College of Medicine, Taoyuan, Taiwan., Wu PR; Department of Physiology and Pharmacology, Chang Gung University College of Medicine, Taoyuan, Taiwan., Weng YH; Division of Movement Disorders, Department of Neurology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Neuroscience Research Center, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address: yhweng2488@gmail.com.
Source: Neurochemistry international [Neurochem Int] 2026 Jul-Aug; Vol. 197, pp. 106186. Date of Electronic Publication: 2026 May 15.
Publication Type: Journal Article
Journal Info: Publisher: Pergamon Press Country of Publication: England NLM ID: 8006959 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9754 (Electronic) Linking ISSN: 01970186 NLM ISO Abbreviation: Neurochem Int Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Lrp10 insufficiency upregulates mRNA and protein of neurotoxic α-synuclein and causes degeneration of substantia nigra dopaminergic neurons in heterozygous or homozygous Lrp10 knockout mice.
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  Data: <searchLink fieldCode="AU" term="%22Wang+HL%22">Wang HL</searchLink>; Department of Physiology and Pharmacology, Chang Gung University College of Medicine, Taoyuan, Taiwan; Division of Movement Disorders, Department of Neurology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Healthy Aging Research Center, Chang Gung University College of Medicine, Taoyuan, Taiwan; Neuroscience Research Center, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+SY%22">Liu SY</searchLink>; Department of Physiology and Pharmacology, Chang Gung University College of Medicine, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chiu+CC%22">Chiu CC</searchLink>; Healthy Aging Research Center, Chang Gung University College of Medicine, Taoyuan, Taiwan; Neuroscience Research Center, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Department of Medical Biotechnology and Laboratory Science, Chang Gung University College of Medicine, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yeh+TH%22">Yeh TH</searchLink>; Department of Neurology, Taipei Medical University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chiu+TJ%22">Chiu TJ</searchLink>; Graduate Institute of Biomedical Sciences, Chang Gung University College of Medicine, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yeh+YC%22">Yeh YC</searchLink>; Department of Physiology and Pharmacology, Chang Gung University College of Medicine, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+PR%22">Wu PR</searchLink>; Department of Physiology and Pharmacology, Chang Gung University College of Medicine, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Weng+YH%22">Weng YH</searchLink>; Division of Movement Disorders, Department of Neurology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Neuroscience Research Center, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address: yhweng2488@gmail.com.
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  Data: <searchLink fieldCode="JN" term="%228006959%22">Neurochemistry international</searchLink> [Neurochem Int] 2026 Jul-Aug; Vol. 197, pp. 106186. <i>Date of Electronic Publication: </i>2026 May 15.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Pergamon+Press%22">Pergamon Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8006959 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1872-9754 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201970186%22">01970186 </searchLink><i>NLM ISO Abbreviation: </i>Neurochem Int <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.neuint.2026.106186
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        Text: English
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        StartPage: 106186
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      – TitleFull: Lrp10 insufficiency upregulates mRNA and protein of neurotoxic α-synuclein and causes degeneration of substantia nigra dopaminergic neurons in heterozygous or homozygous Lrp10 knockout mice.
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              Text: 2026 Jul-Aug
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