Understanding and overcoming innate and acquired MAPK inhibition resistance in anaplastic thyroid cancer.

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Title: Understanding and overcoming innate and acquired MAPK inhibition resistance in anaplastic thyroid cancer.
Authors: Zeng PYF; Department of Otolaryngology - Head & Neck Surgery, Western University, London, ON, Canada; Department of Pathology and Laboratory Medicine, Western University, London, ON, Canada., Meens J; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada., Karimi AH; Department of Otolaryngology - Head & Neck Surgery, Western University, London, ON, Canada; Department of Pathology and Laboratory Medicine, Western University, London, ON, Canada., Pan H; Department of Otolaryngology - Head & Neck Surgery, Western University, London, ON, Canada; Department of Pathology and Laboratory Medicine, Western University, London, ON, Canada., Cecchini MJ; Department of Pathology and Laboratory Medicine, Western University, London, ON, Canada; Department of Oncology, Western University, London, ON, Canada., Jarycki L; Department of Otolaryngology - Head & Neck Surgery, Western University, London, ON, Canada., Ryan SB; Department of Otolaryngology - Head & Neck Surgery, Western University, London, ON, Canada., Dawson AE; Department of Otolaryngology - Head & Neck Surgery, Western University, London, ON, Canada., Shaikh MH; Department of Otolaryngology - Head & Neck Surgery, Western University, London, ON, Canada., Palma DA; Department of Oncology, Western University, London, ON, Canada., Winquist E; Department of Oncology, Western University, London, ON, Canada., Gunaratnam L; Department of Microbiology & Immunology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada; Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre Research Institute, London Health Sciences Centre, London, ON, Canada., Mymryk JS; Department of Otolaryngology - Head & Neck Surgery, Western University, London, ON, Canada; Department of Oncology, Western University, London, ON, Canada; Department of Microbiology & Immunology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada., Barrett JW; Department of Otolaryngology - Head & Neck Surgery, Western University, London, ON, Canada., Boutros PC; Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA; Department of Urology, University of California, Los Angeles, Los Angeles, CA, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA, USA; Institute for Precision Health, University of California, Los Angeles, Los Angeles, CA, USA; Jonsson Comprehensive Cancer Centre, University of California, Los Angeles, Los Angeles, CA, USA., Ailles L; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada. Electronic address: laurie.ailles@uhn.ca., Nichols AC; Department of Otolaryngology - Head & Neck Surgery, Western University, London, ON, Canada; Department of Oncology, Western University, London, ON, Canada. Electronic address: anthony.nichols@lhsc.on.ca.
Source: Cell reports. Medicine [Cell Rep Med] 2026 Jun 16; Vol. 7 (6), pp. 102820. Date of Electronic Publication: 2026 May 15.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Zeng+PYF%22">Zeng PYF</searchLink>; Department of Otolaryngology - Head & Neck Surgery, Western University, London, ON, Canada; Department of Pathology and Laboratory Medicine, Western University, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Meens+J%22">Meens J</searchLink>; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.<br /><searchLink fieldCode="AU" term="%22Karimi+AH%22">Karimi AH</searchLink>; Department of Otolaryngology - Head & Neck Surgery, Western University, London, ON, Canada; Department of Pathology and Laboratory Medicine, Western University, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Pan+H%22">Pan H</searchLink>; Department of Otolaryngology - Head & Neck Surgery, Western University, London, ON, Canada; Department of Pathology and Laboratory Medicine, Western University, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Cecchini+MJ%22">Cecchini MJ</searchLink>; Department of Pathology and Laboratory Medicine, Western University, London, ON, Canada; Department of Oncology, Western University, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Jarycki+L%22">Jarycki L</searchLink>; Department of Otolaryngology - Head & Neck Surgery, Western University, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Ryan+SB%22">Ryan SB</searchLink>; Department of Otolaryngology - Head & Neck Surgery, Western University, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Dawson+AE%22">Dawson AE</searchLink>; Department of Otolaryngology - Head & Neck Surgery, Western University, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Shaikh+MH%22">Shaikh MH</searchLink>; Department of Otolaryngology - Head & Neck Surgery, Western University, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Palma+DA%22">Palma DA</searchLink>; Department of Oncology, Western University, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Winquist+E%22">Winquist E</searchLink>; Department of Oncology, Western University, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Gunaratnam+L%22">Gunaratnam L</searchLink>; Department of Microbiology & Immunology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada; Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre Research Institute, London Health Sciences Centre, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Mymryk+JS%22">Mymryk JS</searchLink>; Department of Otolaryngology - Head & Neck Surgery, Western University, London, ON, Canada; Department of Oncology, Western University, London, ON, Canada; Department of Microbiology & Immunology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Barrett+JW%22">Barrett JW</searchLink>; Department of Otolaryngology - Head & Neck Surgery, Western University, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Boutros+PC%22">Boutros PC</searchLink>; Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA; Department of Urology, University of California, Los Angeles, Los Angeles, CA, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA, USA; Institute for Precision Health, University of California, Los Angeles, Los Angeles, CA, USA; Jonsson Comprehensive Cancer Centre, University of California, Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ailles+L%22">Ailles L</searchLink>; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada. Electronic address: laurie.ailles@uhn.ca.<br /><searchLink fieldCode="AU" term="%22Nichols+AC%22">Nichols AC</searchLink>; Department of Otolaryngology - Head & Neck Surgery, Western University, London, ON, Canada; Department of Oncology, Western University, London, ON, Canada. Electronic address: anthony.nichols@lhsc.on.ca.
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