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Beta-caryophyllene mitigates high fat diet-induced testicular dysfunctions by targeting JNK/ERK-1 and JAK-1/STAT-3 pathways in rats.

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Title: Beta-caryophyllene mitigates high fat diet-induced testicular dysfunctions by targeting JNK/ERK-1 and JAK-1/STAT-3 pathways in rats.
Authors: Muqbil Alsirhani A; Department of Chemistry, College of Science, Jouf University, 72341, Sakaka, Al-Jouf, Saudi Arabia., Alzahrani OR; Department of Biology, Faculty of Science, University of Tabuk, 47512, Tabuk, Saudi Arabia., Abu-Almakarem AS; Department of Basic Medical Sciences, Faculty of Applied Medical Sciences, Al-Baha University, Al-Baha, Saudi Arabia., Al-Sowayan NS; Department of Biology, College of Science, Qassim University, 52377, Buraidah, Saudi Arabia. nsaoiean@qu.edu.sa., Shakoori AM; Department of Clinical Laboratory sciences, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia., AlRashidi AA; Chemistry Department, Faculty of Science, University of Ha'il, 81451, Ha'il, Saudi Arabia., Aljohani S; Department of Chemistry, College of Science, Taibah University, Madinah, Saudi Arabia., Aljarari RM; Department of Biological Sciences, College of Science, University of Jeddah, Jeddah, Saudi Arabia., Alowaidi SA; Department of Biology, Faculty of Sciences, King Abdulaziz University, Jeddah, Saudi Arabia., Mobasher MA; Department of Pathology, Biochemistry Division, College of Medicine, Jouf University, 72388, Sakaka, Saudi Arabia., El-Said KS; Biochemistry Division, Chemistry Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt.
Source: Scientific reports [Sci Rep] 2026 May 16. Date of Electronic Publication: 2026 May 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Muqbil+Alsirhani+A%22">Muqbil Alsirhani A</searchLink>; Department of Chemistry, College of Science, Jouf University, 72341, Sakaka, Al-Jouf, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Alzahrani+OR%22">Alzahrani OR</searchLink>; Department of Biology, Faculty of Science, University of Tabuk, 47512, Tabuk, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Abu-Almakarem+AS%22">Abu-Almakarem AS</searchLink>; Department of Basic Medical Sciences, Faculty of Applied Medical Sciences, Al-Baha University, Al-Baha, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Al-Sowayan+NS%22">Al-Sowayan NS</searchLink>; Department of Biology, College of Science, Qassim University, 52377, Buraidah, Saudi Arabia. nsaoiean@qu.edu.sa.<br /><searchLink fieldCode="AU" term="%22Shakoori+AM%22">Shakoori AM</searchLink>; Department of Clinical Laboratory sciences, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22AlRashidi+AA%22">AlRashidi AA</searchLink>; Chemistry Department, Faculty of Science, University of Ha'il, 81451, Ha'il, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Aljohani+S%22">Aljohani S</searchLink>; Department of Chemistry, College of Science, Taibah University, Madinah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Aljarari+RM%22">Aljarari RM</searchLink>; Department of Biological Sciences, College of Science, University of Jeddah, Jeddah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Alowaidi+SA%22">Alowaidi SA</searchLink>; Department of Biology, Faculty of Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Mobasher+MA%22">Mobasher MA</searchLink>; Department of Pathology, Biochemistry Division, College of Medicine, Jouf University, 72388, Sakaka, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22El-Said+KS%22">El-Said KS</searchLink>; Biochemistry Division, Chemistry Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt.
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              Text: 2026 May 16
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