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Calpain cleaves the distal carboxyl terminus of TRPV1 and modulates its tachyphylaxis.

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Title: Calpain cleaves the distal carboxyl terminus of TRPV1 and modulates its tachyphylaxis.
Authors: Jiang JY; Department of Neurobiology, School of Basic Medical Sciences and Neuroscience Research Institute, Peking University, 38 Xueyuan Road, 100191, Beijing, China.; Key Lab for Neuroscience, Ministry of Education/National Health Commission of China, Peking University, 38 Xueyuan Road, Beijing, 100191, China., Wang XC; The First Affiliated Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, 310003, China., Yang J; Lishui People's Hospital, The First Affiliated Hospital of Lishui University, Lishui, 323000, Zhejiang, China., Gao SW; Department of Neurobiology, School of Basic Medical Sciences and Neuroscience Research Institute, Peking University, 38 Xueyuan Road, 100191, Beijing, China.; Key Lab for Neuroscience, Ministry of Education/National Health Commission of China, Peking University, 38 Xueyuan Road, Beijing, 100191, China., Xu JX; Department of Neurobiology, School of Basic Medical Sciences and Neuroscience Research Institute, Peking University, 38 Xueyuan Road, 100191, Beijing, China.; Key Lab for Neuroscience, Ministry of Education/National Health Commission of China, Peking University, 38 Xueyuan Road, Beijing, 100191, China., Chen ML; Department of Neurobiology, School of Basic Medical Sciences and Neuroscience Research Institute, Peking University, 38 Xueyuan Road, 100191, Beijing, China.; Key Lab for Neuroscience, Ministry of Education/National Health Commission of China, Peking University, 38 Xueyuan Road, Beijing, 100191, China., Zhang ZZ; Department of Neurobiology, School of Basic Medical Sciences and Neuroscience Research Institute, Peking University, 38 Xueyuan Road, 100191, Beijing, China.; Key Lab for Neuroscience, Ministry of Education/National Health Commission of China, Peking University, 38 Xueyuan Road, Beijing, 100191, China., Liu J; Center of Medical and Health Analysis, Peking University Health Science Center, Beijing, 100191, China., Wang Y; Department of Neurobiology, School of Basic Medical Sciences and Neuroscience Research Institute, Peking University, 38 Xueyuan Road, 100191, Beijing, China.; Key Lab for Neuroscience, Ministry of Education/National Health Commission of China, Peking University, 38 Xueyuan Road, Beijing, 100191, China.; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, China., Liang P; The First Affiliated Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, 310003, China. pingliang@zju.edu.cn.; The First Affiliated Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, 268 Kaixuan Road, Hangzhou, 310029, China. pingliang@zju.edu.cn., Zhang Y; Department of Neurobiology, School of Basic Medical Sciences and Neuroscience Research Institute, Peking University, 38 Xueyuan Road, 100191, Beijing, China. zhangyingnri@bjmu.edu.cn.; Key Lab for Neuroscience, Ministry of Education/National Health Commission of China, Peking University, 38 Xueyuan Road, Beijing, 100191, China. zhangyingnri@bjmu.edu.cn.
Source: Cell & bioscience [Cell Biosci] 2026 May 17. Date of Electronic Publication: 2026 May 17.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101561195 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2045-3701 (Print) Linking ISSN: 20453701 NLM ISO Abbreviation: Cell Biosci
Database: MEDLINE Ultimate
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  Data: Calpain cleaves the distal carboxyl terminus of TRPV1 and modulates its tachyphylaxis.
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  Data: <searchLink fieldCode="AU" term="%22Jiang+JY%22">Jiang JY</searchLink>; Department of Neurobiology, School of Basic Medical Sciences and Neuroscience Research Institute, Peking University, 38 Xueyuan Road, 100191, Beijing, China.; Key Lab for Neuroscience, Ministry of Education/National Health Commission of China, Peking University, 38 Xueyuan Road, Beijing, 100191, China.<br /><searchLink fieldCode="AU" term="%22Wang+XC%22">Wang XC</searchLink>; The First Affiliated Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, 310003, China.<br /><searchLink fieldCode="AU" term="%22Yang+J%22">Yang J</searchLink>; Lishui People's Hospital, The First Affiliated Hospital of Lishui University, Lishui, 323000, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Gao+SW%22">Gao SW</searchLink>; Department of Neurobiology, School of Basic Medical Sciences and Neuroscience Research Institute, Peking University, 38 Xueyuan Road, 100191, Beijing, China.; Key Lab for Neuroscience, Ministry of Education/National Health Commission of China, Peking University, 38 Xueyuan Road, Beijing, 100191, China.<br /><searchLink fieldCode="AU" term="%22Xu+JX%22">Xu JX</searchLink>; Department of Neurobiology, School of Basic Medical Sciences and Neuroscience Research Institute, Peking University, 38 Xueyuan Road, 100191, Beijing, China.; Key Lab for Neuroscience, Ministry of Education/National Health Commission of China, Peking University, 38 Xueyuan Road, Beijing, 100191, China.<br /><searchLink fieldCode="AU" term="%22Chen+ML%22">Chen ML</searchLink>; Department of Neurobiology, School of Basic Medical Sciences and Neuroscience Research Institute, Peking University, 38 Xueyuan Road, 100191, Beijing, China.; Key Lab for Neuroscience, Ministry of Education/National Health Commission of China, Peking University, 38 Xueyuan Road, Beijing, 100191, China.<br /><searchLink fieldCode="AU" term="%22Zhang+ZZ%22">Zhang ZZ</searchLink>; Department of Neurobiology, School of Basic Medical Sciences and Neuroscience Research Institute, Peking University, 38 Xueyuan Road, 100191, Beijing, China.; Key Lab for Neuroscience, Ministry of Education/National Health Commission of China, Peking University, 38 Xueyuan Road, Beijing, 100191, China.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Center of Medical and Health Analysis, Peking University Health Science Center, Beijing, 100191, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Neurobiology, School of Basic Medical Sciences and Neuroscience Research Institute, Peking University, 38 Xueyuan Road, 100191, Beijing, China.; Key Lab for Neuroscience, Ministry of Education/National Health Commission of China, Peking University, 38 Xueyuan Road, Beijing, 100191, China.; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, China.<br /><searchLink fieldCode="AU" term="%22Liang+P%22">Liang P</searchLink>; The First Affiliated Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, 310003, China. pingliang@zju.edu.cn.; The First Affiliated Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, 268 Kaixuan Road, Hangzhou, 310029, China. pingliang@zju.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Neurobiology, School of Basic Medical Sciences and Neuroscience Research Institute, Peking University, 38 Xueyuan Road, 100191, Beijing, China. zhangyingnri@bjmu.edu.cn.; Key Lab for Neuroscience, Ministry of Education/National Health Commission of China, Peking University, 38 Xueyuan Road, Beijing, 100191, China. zhangyingnri@bjmu.edu.cn.
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      – TitleFull: Calpain cleaves the distal carboxyl terminus of TRPV1 and modulates its tachyphylaxis.
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              M: 05
              Text: 2026 May 17
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